Family history and risk of type 1 diabetes mellitus

Šipetić, Sandra; Vlajinac, Hristina; Kocev, Nikola; Marinković, Jelena; Radmanović, S; Denić, Ljiljana Marković

doi:10.1007/s005920200028

Cited by 37 publications

(26 citation statements)

References 15 publications

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“…In previous reports, this proportion has ranged from 20 to 70% (1,2,3,8,18,20,36). These studies, however, vary in terms of T1D duration, possible screening of family members for autoantibodies, and the categories of relatives included in the analysis.…”

Section: Discussionmentioning

confidence: 99%

Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes

Parkkola

Härkönen

Ryhänen

et al. 2013

European Journal of Endocrinology

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Objective: Based on the concept of clustering autoimmunity, children with a positive family history of autoimmunity could be expected to have a different pathogenetic form of type 1 diabetes (T1D) and thus a stronger autoimmune reactivity against b-cells and an increased prevalence of the HLA-DR3-DQ2 haplotype.Design and methods: We tested this hypothesis in a cross-sectional observational study from the Finnish Pediatric Diabetes Register. HLA class II genotypes and b-cell autoantibodies were analyzed, and data on the extended family history of autoimmunity and clinical markers at diagnosis were collected with a structured questionnaire from 1488 children diagnosed with T1D under the age of 15 years (57% males). Results: Only 23 children (1.5%) had another autoimmune disease (AID) known at diagnosis, and they had a milder metabolic decompensation at diabetes presentation. One-third (31.4%) had at least one relative with an AID other than T1D with affected mothers being overrepresented (8.2%) compared with fathers (2.8%). The children with a positive family history of other AIDs had higher levels of islet cell antibodies (PZ0.003), and the HLA-DR3-DQ2 haplotype in the children was associated with celiac disease in the extended family (P!0.001), but not with an increased frequency of autoimmune disorders, in general.Conclusions: Approximately one-third of children with newly diagnosed T1D have a first-and/or second-degree relative affected by an AID. Our data do not consistently support the hypothesis of differential pathogenetic mechanisms in such children.

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Section: Discussionmentioning

confidence: 99%

Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes

Parkkola

Härkönen

Ryhänen

et al. 2013

European Journal of Endocrinology

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“…That one-third of children with type 1 diabetes had a family history of the disease in fi rst-degree relatives is consistent with the notion that diabetes aetiology involves exposure to environmental factors in genetically susceptible individuals. Children with fi rst-degree relatives having type 1 diabetes are at increased risk for developing the disease [19] . Kuwait is a genetically susceptible population.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Type 1 Diabetes among 6- to 18-Year-Old Kuwaiti Children

Moussa

Alsaeid²,

Abdella³

et al. 2005

Med Princ Pract

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Objectives: To determine the prevalence of type 1 diabetes among 6- to 18-year-old Kuwaiti children according to gender, age, and region. Subjects and Methods: Children with type 1 diabetes aged 6–18 years were identified at 182 schools (50 primary, 63 intermediate, and 69 secondary) in Kuwait during the study period October 2000 to September 2002. Schools were randomly selected using the 2000/01 educational districts’ registers as sampling frame proportional to the number of schools in each district. Prevalence rates were adjusted to the 2002 Kuwaiti population. Diagnosis of type 1 diabetes was based on the World Health Organization, and the American Diabetes Association criteria. Results: Prevalence of type 1 diabetes was 269.9 per 100,000 (95% confidence interval, CI 241.6–298.3). There was no significant difference in prevalence between male (247.6, 95% CI 205.2–290.0) and female (285.5, 95% CI 247.5–323.5). Type 1 diabetes was more prevalent in the age group 10–13 years (347.3), and lowest in the age group 6–9 years (182.6) per 100,000; the difference was significant at p < 0.001. The overall age-adjusted prevalence rate was 252.9 (95% CI 234.6–271.2), 229.1 (95% CI 204.6–253.6) in male and 277.4 (95% CI 250.0–304.7) in female children in the 2002 Kuwaiti population. The mean age at onset was 9.2, and 8.1 years in male and female children, respectively (p = 0.018). There was no significant difference in prevalence between regions. Conclusion: Type 1 diabetes is a common chronic disease in Kuwaiti children.

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“…In all, a total of 54 children were included in this study: 27 subjects with type 1 diabetes, 14 subjects with a first-degree relative having type 1 diabetes 14,15 or CD, 16 and 13 children having HLA-DQ2. Of these, 34 had biopsy confirmation of CD and 20 had intestine biopsies without evidence of villus atrophy.…”

Section: Subjectsmentioning

confidence: 99%