Family disruption increases functional somatic symptoms in late adolescence: The TRAILS Study.

Gils, Anne van; Janssens, Karin A.M.; Rosmalen, Judith

doi:10.1037/hea0000073

Cited by 27 publications

(16 citation statements)

References 44 publications

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“…We found that associations of childhood psychological problems with chronic disabling fatigue were confounded by maternal psychopathology. Although no previous studies have had sufficient power to explore risk factors with chronic disabling fatigue in children, our results are consistent with those that explored family disruption as a risk factor for functional somatic symptoms in adolescence [33]. Too few ALSPAC participants had experienced sexual and physical abuse; hence, we were unable to investigate whether the association between childhood abuse and CFS/ME in adults [34] could be replicated in this prospective cohort.…”

Section: Comparison With the Literaturesupporting

confidence: 91%

Maternal and Childhood Psychological Factors Predict Chronic Disabling Fatigue at Age 13 Years

Collin

Tilling

Joinson

et al. 2015

Journal of Adolescent Health

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Pediatricians need to be aware that children whose mothers experience anxiety and/or depression between pregnancy and child's age 6 years have an increased risk of developing chronic disabling fatigue in early adolescence. Conversely, clinicians need to be alert to fatigue in children whose mothers have longstanding anxiety and depression. These findings suggest the importance of family-based approaches to treatment.

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Section: Comparison With the Literaturesupporting

confidence: 91%

Maternal and Childhood Psychological Factors Predict Chronic Disabling Fatigue at Age 13 Years

Collin

Tilling

Joinson

et al. 2015

Journal of Adolescent Health

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“…Development of early interventions are needed to prevent future morbidity and financial costs. These could be inspired by existing interventions, for medically unexplained symptoms in adults and should engage not only the young person but also the family as a whole [41][42][43][44] . Figure 3.…”

Section: Discussionmentioning

confidence: 99%

Non-specific Health complaints and self-rated health in pre-adolescents; impact on primary health care use

Rytter

Rask

Vestergaard

et al. 2020

Sci Rep

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The objective of the present study was to explore past and future primary health care use in preadolescents reporting frequent non-specific health complaints or a low self-rated health compared to that of preadolescents with no frequent health complaints or with good self-rated health. The study was conducted as a cohort study based within the Danish National Birth Cohort (1996-2002). Information on non-specific health complaints and self-rated health was obtained by an 11-year follow-up questionnaire. Information about number of general practitioner (GP) contacts was obtained from the Health Insurance Service Register. A total of 44,877 pre-adolescents gave complete exposure information. Pre-adolescents who reported frequent non-specific health complaints had a higher use of GP compared to pre-adolescents without complaints across the five years following the index date (somatic complaints: IRR = (1.46 [1.38; 1.55], mental complaints: IRR = 1.16 [1.12; 1.19], both complaints: IRR = 1.58 [1.47; 1.69]). The same pattern was found for the association between low self-rated health and number of GP contacts (IRR = 1.41 (1.36; 1.46)). Non-specific health complaints and a poor self-rated health in pre-adolescents was associated with a higher past and future use of GP, indicating a need for development of early interventions with help for symptom management.

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“…There is increasing evidence from both cross-sectional [10,17,[29][30][31][32][33] and prospective studies [34][35][36][37][38][39][40] that childhood trauma is an important risk factor for CFS. Early life stress exposure may influence DNA methylation of HPA axis related genes, subsequently altering HPA reactivity, which in turn may represent a risk factor for stress-related disorders, including CFS [41].…”

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confidence: 99%

Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients

Vangeel

Kempke

Bakusic

et al. 2018

Journal of Psychosomatic Research

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Family disruption increases functional somatic symptoms in late adolescence: The TRAILS Study.

Abstract: Family disruption is associated with an increased level of FSSs in late adolescence in both genders. This relationship is partly explained by symptoms of depression and/or anxiety.

Cited by 27 publications

References 44 publications

Maternal and Childhood Psychological Factors Predict Chronic Disabling Fatigue at Age 13 Years

Maternal and Childhood Psychological Factors Predict Chronic Disabling Fatigue at Age 13 Years

Non-specific Health complaints and self-rated health in pre-adolescents; impact on primary health care use

Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients

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