Family-directed umbilical cord blood banking

Gluckman, Éliane; Ruggeri, Annalisa; Rocha, Vanderson; Baudoux, Étienne; Boo, Michael; Kurtzberg, Joanne; Welte, K.; Navarrete, Cristina; Walraven, Suzanna M. van

doi:10.3324/haematol.2011.047050

Cited by 64 publications

(33 citation statements)

References 33 publications

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“…Increasing use of preimplantation genetic diagnosis (PGD) with HLA matching in Thalassemia endemic regions as South East Asia will see the rise of subsequent related allogeneic cord blood stem cell transplantation both in Thalassemia [9] but also other hereditary conditions [8,9]. Increasing favourable evidence for the potential of autologous UCB in cerebral palsy [10][11][12][13], traumatic and/ or hypoxic brain injury [14,15], diabetes [6,7] and deafness [6,7] may influence UCB banking [16,17]. Hepatitis B virus (HBV) infection remains a major global public health problem, despite the availability of a highly effective vaccine and improvements in antiviral therapy [18].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in view of the recent evidence of UCB's HSC plasticity and the strong evidence supporting the concept that HSCs are pluripotent and the source for the majority, if not all, of the cell types in our body [5], autologous and related allogeneic UCB stem cell storage offers an opportunity for many families for use in future regenerative medical purposes [6,7]. Increasing use of preimplantation genetic diagnosis (PGD) with HLA matching and subsequent related allogeneic cord blood HSCT in Thalassemia [8,9], endemic in South East Asia, and other hereditary conditions [8] and along with favourable support for autologous UCB use in cerebral palsy [10,11,12,13], traumatic and/or hypoxic brain injury [14,15], diabetes [6,7], and deafness [6,7] has already started transforming the field of UCB banking.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Fongsarun¹,

Ekkapongpisit²,

Paisan³

et al. 2013

Transplant Technol

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Background: To provide information on the prevalence of transmissible viral disease in a Thai cohort of 2101 consecutive maternal blood samples of autologous umbilical cord blood (UCB) stored in a private cord blood bank. Materials and methods: Transmissible viral disease screening in 2101 consecutive maternal blood samples was performed serologically using the CMIA technique on an Architect i1000SR for Hepatitis B Virus (HBV) (HBsAg and Anti-HBc), Hepatitis C Virus (HCV) (anti-HCV), Human Immunodeficiency Virus (HIV) (HIV Ag/Ab Combo), Human TLymphotropic Virus type 1 and 2 (HLTV 1/2) (Anti-HTLV 1/2) and Cytomegalovirus (CMV) (CMV-IgG and CMV-IgM). Nucleic Acid Tests (NAT) were used as confirmatory tests for HBV, HIV and HCV. The prevalence of transmissible viral disease and comparisons between serological screening and NAT testing were studied and reported in this study. Results: In 2101 consecutive maternal serum samples, the positive rate of HBV-NAT was 1.62%, HCV-NAT was 0.14%, HIV-NAT was 0%, HBsAg was 2.52%, anti-HBc was 16.85%, anti-HCV was 0.33%, and HIV Ag/Ab combo was borderline but finally negative in one case. In HBsAg positive samples the positive rate of HBV-NAT was 64.15% while in anti HBc positive samples, the positive rate of HBV-NAT was 9.6%. In anti HCV positive samples, the positive rate of HCV-NAT was 42.86%. The positive rate of HTLV 1/2 was 0% and borderline in 0.19% but finally reconfirmed negative in all cases. The positive rate of CMV-IgG was 86.53% while CMV-IgM was 0.33%. Conclusions:In the present study, in a Thai cohort of maternal blood samples of autologous UCB stored in a private cord blood bank, very low prevalence of transmissible viral disease was noted. HBV, HCV and CMV prevalences were lower than observed in the general Thai population, possibly due to widespread of vaccine immunization, and the higher socioeconomic status of the mothers opting for private UCB banking. Due to our screening procedures, HIV could not be detected in any of the maternal sera. HTLV 1/2 could not be detected in any of the samples and this is the first report of its prevalence in Thailand in almost 20 years. The low prevalence of CMV IgM reinforces UCBs advantage in HSCT. The molecular biology techniques would make up for the default of the serological methods.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Fongsarun¹,

Ekkapongpisit²,

Paisan³

et al. 2013

Transplant Technol

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“…In a series of single patient trials in children for whom no donor was available, cord blood preserved from their younger siblings has been introduced as a third source of HSCs in the clinic. This transplant source has been originally established for patients in lack of a suitable donor using either family members or unrelated donors, and has since been established as a valuable transplant source for children [35,36]. Routinely, most current HCT grafts nowadays contain in addition to HSCs both accompanying progenitor cells and different mature cell types (fig.…”

Section: What Is An Ideal Hematopoietic Cell Graft?mentioning

confidence: 99%

Hematopoietic Stem Cells in Regenerative Medicine: Astray or on the Path?

Müller

Huppertz

Henschler

2016

Transfus Med Hemother

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Hematopoietic stem cells (HSCs) are the best characterized adult stem cells and the only stem cell type in routine clinical use. The concept of stem cell transplantation laid the foundations for the development of novel cell therapies within, and even outside, the hematopoietic system. Here, we report on the history of hematopoietic cell transplantation (HCT) and of HSC isolation, we briefly summarize the capabilities of HSCs to reconstitute the entire hemato/lymphoid cell system, and we assess current indications for HCT. We aim to draw the lines between areas where HCT has been firmly established, areas where HCT can in the future be expected to be of clinical benefit using their regenerative functions, and areas where doubts persist. We further review clinical trials for diverse approaches that are based on HCT. Finally, we highlight the advent of genome editing in HSCs and critically view the use of HSCs in non-hematopoietic tissue regeneration.

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“…Although private cord blood banks (CBBs) were initially founded for autologous or family use [13], the first public CBB was established in the USA in 1993, and currently about 400,000 UCB units are held worldwide in more than 50 public CBBs [14]. In Iran there are 1 private and 3 public CBBs.…”

Section: Introductionmentioning

confidence: 99%

The Royan Public Umbilical Cord Blood Bank: Does It Cover All Ethnic Groups in Iran Based on HLA Diversity?

Ebrahimkhani

Farjadian

Ebrahimi

2014

Transfus Med Hemother

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Background: Umbilical cord blood (UCB) stem cells allow the transplantation of partially human leukocyte antigen (HLA)-matched grafts and are a valuable resource for the treatment of hematologic malignancies and heritable hematologic, immunologic and metabolic diseases, especially when a compatible bone marrow donor is unavailable. The aim of this study was to determine how many ethnic groups in Iran are covered by the available UCB units based on HLA diversity. Methods: From 2009 until mid-2013, 4,981 (30.3%) of the 16,437 UCB samples collected met the storage criteria and were cryopreserved at a public cord blood bank (CBB) in Tehran, Iran. HLA-A, -B and -DRB1 were typed in 1,793 samples. Results: The mean volume of the cryopreserved samples was 81.25 ± 20.3 ml. The range of total nucleated cells per unit was 51 × 10⁷-107 × 10⁷. The most common HLA alleles were HLA-A*2 (17%) and HLA-A*24 (15.6%), HLA-B*35 (16.8%) and HLA-B*51 (13.9%), and HLA-DRB1*11 (20%) and HLA-DRB1*15 (14%). The predominant haplotypes were HLA-A*24-B*35-DRB1*11 (2%), HLA-A*02-B*50-DR*07 (1.8%), and HLA-A*02-B*51-DRB1*11 (1.5%). Conclusions: Based on the HLA-DRB1 profiles, the UCB units available at the Royan public UCB bank are a potentially adequate resource for hematopoietic stem cell transplantation for Iranian recipients belonging to particular ethnic groups. Regular educational programs to improve the public knowledge of UCB for transplantation can enhance the public CBB stocks for all Iranian ethnic groups in the future.

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Family-directed umbilical cord blood banking

Abstract: Family-directed umbilical cord blood banking haematologica | 2011; 96(11) 1705

Cited by 64 publications

References 33 publications

Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Prevalence of transmissible viral disease in maternal blood samples of autologous umbilical cord blood in a private cord blood bank

Hematopoietic Stem Cells in Regenerative Medicine: Astray or on the Path?

The Royan Public Umbilical Cord Blood Bank: Does It Cover All Ethnic Groups in Iran Based on HLA Diversity?

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