Family-Based Association Study of Lithium-Related and Other Candidate Genes in Bipolar Disorder

Perlis, Roy H.; Purcell, Shaun; Fagerness, Jesen; Kirby, Andrew; Petryshen, Tracey L.; Fan, Jinbo; Sklar, Pamela

doi:10.1001/archgenpsychiatry.2007.15

Cited by 60 publications

(40 citation statements)

References 123 publications

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“…A link between sialyltransferase 4A and bipolar disorder has been reported previously. 27 We also identified seven SNPs with Pp3.33 Â 10 À5 located near DRD1 on chromosome 5q35 (Figure 3). DRD1 has a role in behavior and psychiatric disorders, including schizophrenia, 28 autism, 29 attentiondeficit-hyperactivity disorder, 30 nicotine dependence 31 and alcohol dependence.…”

Section: Neuroticismmentioning

confidence: 89%

Genome-wide association study of the five-factor model of personality in young Korean women

et al. 2013

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Personality is a determinant of behavior and lifestyle associated with health and human diseases. Although personality is known to be a heritable trait, its polygenic nature has made the identification of genetic variants elusive. We performed a genome-wide association study on 1089 Korean women aged 18-40 years whose personality traits were measured with the Revised NEO Personality Inventory for the five-factor model of personality. To reduce environmental factors that may influence personality traits, this study was restricted to young adult women. In the discovery phase, we identified variants of PTPRD (protein tyrosine phosphatase, receptor type D) that associated this gene with the Openness domain. Other genes that were previously reported to be associated with neurological phenotypes were also associated with personality traits. In particular, DRD1 and ORIA2 were linked to Neuroticism, NKAIN2 with Extraversion, HTR5A with Openness and DRD3 with Agreeableness. Data from our replication study of 2090 subjects confirmed the association between ORIA2 and Neuroticism. We first identified and confirmed a novel region on ORIA2 associated with Neuroticism. Candidate genes for psychiatric disorders were also enriched. These findings contribute to our understanding of the genetic architecture of personality traits and provide critical clues to the neurobiological mechanisms that influence them.

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Section: Neuroticismmentioning

confidence: 89%

Genome-wide association study of the five-factor model of personality in young Korean women

et al. 2013

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“…These authors suggested that polymorphisms in DISC1 contribute to variations in the psychotic features of bipolar spectrum disorder. DISC1 may represent a new target for the development treatments and diagnostic tools for bipolar disorder 41 . DISC1 is associated with lowered biological activity of ERK (extracellular regulated kinase), reduced grey matter volume in the brain and increased risk for major depressive disorder 43 .…”

Section: Discussionmentioning

confidence: 99%

“…An analysis of these articles associated identified five genes as the most cited in the literature: CANAC1C [16][17][18][19][20][21][22][23][24] , DAOA [25][26][27][28][29][30][31][32] 22 . Some articles related the genetic polymorphism specifying the classification of TBI 8,25,27,32,35,36,39,41 , in addition to TBI and II 37 . The population studied by the authors of the articles are mostly from ocidente 18,20,22,26,28,30,32,[34][35][36][37][38] and a lower part are the oriente 25,27,33,43 .…”

Section: Genes and Polymorphisms Associated With Demonstrationmentioning

confidence: 99%

“…The functionality of the polymorphisms identified was observed made to analyze the variation in the expression of genetic polymorphism in association with some variables: cognitive assessment 39 , memory 39,41 , making decision 39 . Psychotic illness after the use of alcohol, drug dependence, intravenous drug abuse, psychotic illness secondary to medicamentos 20 .…”

Section: Genes and Polymorphisms Associated With Demonstrationmentioning

confidence: 99%

“…First age 36 , number of episodes, family history of disease psyquiatric 8,36 on first and second grau 25 . Attention 41 . These variables have been showing greater respect of the polymorphisms and episodes of TB, which when studied polymorphism with TB diagnosis.…”

Section: Genes and Polymorphisms Associated With Demonstrationmentioning

confidence: 99%

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Associação entre polimorfismos genéticos e transtorno bipolar

Alves¹,

Silva²,

Neto³

et al. 2012

Rev. psiquiatr. clín.

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Bipolar disorder (BD) is a common disorder that affects approximately 1% of the population. It is associated with both chronic and acute severe features, such as low remission rates and a high prevalence of clinical and psychiatric comorbidities. The aim of the present article is to synthesize data from various articles that investigated genetic polymorphisms associated with BD. The 129 articles selected identified 79 (85.87%) genes associated with BD. This analysis identified the five genes that are the most cited in the literature: CANAC1C, DAOA, TPH2, ANK3 and DISC1. Of the 92 genes identified in these articles, 33 (35.87%) showed no association with BD. This analysis showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD, further research is still required to elucidate its influence on this disorder.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Keywords: Bipolar disorder, genes, polymorphisms, heredity, gene ontology, association with bipolar disorder. ResumoTranstorno bipolar (TB) é uma doença comum que afeta aproximadamente 1% da população. Apresenta características crônicas e agudas graves, com índices de remissão de baixa e alta prevalência de comorbidades clínicas e psiquiátricas. O objetivo do presente artigo é sintetizar dados de vários artigos que investigaram polimorfismos genéticos associados com TB. Dentre os 129 artigos selecionados, identificaram-se 79 (85,87%) genes associados com TB. Essa análise identificou cinco genes que são os mais citados na literatura: CANAC1C, DAOA, TPH2, ANK3 e DISC1. Dos 92 genes identificados nesses artigos, 33 (35,87%) não mostraram associação com TB. Essa análise mostrou que, apesar dos avanços recentes com relação ao papel do polimorfismo genético na predisposição para TB, mais pesquisas ainda são necessárias para elucidar sua influência sobre esse transtorno.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Palavras-chave: Transtorno bipolar, genes, polimorfismos, hereditariedade, ontologia genética, associação com transtorno bipolar.

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Classical Genetic Studies of Schizophrenia

Riley

Kendler

2010

Schizophrenia

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Family-Based Association Study of Lithium-Related and Other Candidate Genes in Bipolar Disorder

Abstract: These results suggest novel candidates and 1 gene (DISC1) previously associated with schizophrenia that merit further study in bipolar disorder. However, polymorphisms in major lithium-signaling genes do not appear to contribute substantially to bipolar liability.

Cited by 60 publications

References 123 publications

Genome-wide association study of the five-factor model of personality in young Korean women

Genome-wide association study of the five-factor model of personality in young Korean women

Associação entre polimorfismos genéticos e transtorno bipolar

Classical Genetic Studies of Schizophrenia

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