Familial transmission of prostate, breast and colorectal cancer in adoptees is related to cancer in biological but not in adoptive parents: A nationwide family study

Zöller, Bengt; Li, Xinjun; Sundquist, Jan; Sundquist, Kristina

doi:10.1016/j.ejca.2014.05.018

Cited by 5 publications

(1 citation statement)

References 36 publications

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“…Lack of genetic FHx is not inconsequential; for example, a recent Swedish study of adoptees emphasizes the importance of genetic factors over environmental factors for several cancers. 4 Current genetic testing capabilities are at a stage where it is legitimate to ask, “Could targeted genetic analysis offer any potential benefit for those individuals who have no or limited access to family history, such as many adoptees?” And might the potential benefits and risks of genetic analysis differ between adoptees and those with access to their family history information?…”

mentioning

confidence: 99%

Can targeted genetic testing offer useful health information to adoptees?

May

Strong

Khoury

et al. 2015

Genetics in Medicine

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mentioning

confidence: 99%

Can targeted genetic testing offer useful health information to adoptees?

May

Strong

Khoury

et al. 2015

Genetics in Medicine

View full text Add to dashboard Cite

Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study

Kohno

Niihara

et al. 2016

Journal of the American College of Surgeons

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Familial transmission of chronic obstructive pulmonary disease in adoptees: a Swedish nationwide family study

Zöller

Sundquist

et al. 2015

BMJ Open

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ObjectivesFamilial clustering of chronic obstructive pulmonary disease (COPD) is well established, but the familial risk of COPD has not been determined among adoptees. The aim was to determine whether the familial transmission of COPD is related to disease in biological and/or adoptive parents.DesignHistoric cohort study.Participants80 214 (50% females).MethodsThe Swedish Multi-Generation Register was used to follow all Swedish-born adoptees born in 1932–2004 (n=80 214) between 1 January 1964 and 31 December 2010 for COPD (n=1978). The risk of COPD was estimated in adoptees with at least one biological parent with COPD but no adoptive parent with COPD (n=162) compared with adoptees without a biological or adoptive parent with COPD. The risk of COPD was also determined in adoptees with at least one adoptive parent but no biological parent with COPD (n=110), and in adoptees with both affected biological and adoptive parents (n=162).Primary outcome measureCOPD in adoptees.ResultsAdoptees with COPD in at least one biological parent but no adoptive parent were more likely to have COPD than adoptees without a biological or adoptive parent with COPD (standardised incidence ratio, SIR=1.98 (95% CI 1.69 to 2.31)). The familial SIR for adoptees with both a biological parent and an adoptive parent with COPD was 1.68 (95% CI 1.39 to 2.00). Adoptees with at least one adoptive parent with COPD but no biological parent with COPD were not at an increased risk of COPD (SIR=1.12 (95% CI 0.92 to 1.35)).ConclusionsThe findings of the study show that the familial transmission of COPD is associated with COPD in biological but not adoptive parents, suggesting that genetic or early life factors are important in the familial transmission of COPD.

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Familial transmission of prostate, breast and colorectal cancer in adoptees is related to cancer in biological but not in adoptive parents: A nationwide family study

Cited by 5 publications

References 36 publications

Can targeted genetic testing offer useful health information to adoptees?

Can targeted genetic testing offer useful health information to adoptees?

Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study

Familial transmission of chronic obstructive pulmonary disease in adoptees: a Swedish nationwide family study

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