Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study

Kohno, Kunie; Niihara, Hiroyuki; Li, Xinjun; Hamano, Tsuyoshi; Nabika, Toru; Shiwaku, Kuninori; Isomura, Minoru; Morita, Eishin; Sundquist, Kristina; Zöller, Bengt

doi:10.1016/j.jamcollsurg.2016.06.007

Cited by 7 publications

(7 citation statements)

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“…In a previous study, we revealed that the main risk factors for VV were standing upright at work, high body mass index (BMI), increased age and female sex in the elderly Japanese population . Besides the above, environmental factors have been well documented as risk factors for VV, although genetic factors may have a substantial contribution in their pathogenesis . As one of the environmental factors, lifestyle in particular is modifiable; therefore, it is important to elucidate the impact of lifestyle for the prevention strategy.…”

Section: Introductionmentioning

confidence: 99%

“…5 Besides the above, environmental factors have been well documented as risk factors for VV, although genetic factors may have a substantial contribution in their pathogenesis. 6 As one of the environmental factors, lifestyle in particular is modifiable; therefore, it is important to elucidate the impact of lifestyle for the prevention strategy. Despite robust evidence of alcohol drinking on vascular disease, no study has examined the effect of alcohol on VV by its consumption levels.…”

Section: Introductionmentioning

confidence: 99%

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J‐curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study

Kohno

Niihara

Hamano

et al. 2019

The Journal of Dermatology

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The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross‐sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle‐related factors and medical history, compared with non‐drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1–5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J‐curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence‐based patient education.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

J‐curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study

Kohno

Niihara

Hamano

et al. 2019

The Journal of Dermatology

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“…Mokhtari et al and Gökçe et al both described a significant increase in the prevalence of varicocele after a post-hoc examination of first-degree relatives ( 18 , 19 ). While genetic factors were also shown to make a strong contribution to the familial transmission of varicose veins from parents to offspring, no studies have looked into a possible hereditary association with varicocele ( 20 ). The current study had two primary aims: To calculate the prevalence of varicoceles in fathers of patients with diagnosed pediatric varicoceles, and additionally, to examine association between patients with varicocele and varicose veins in their first-degree relatives.…”

Section: Introductionmentioning

confidence: 99%

The role of inheritance in the development of adolescent varicoceles

Griffiths

Vasudevan

Myers

et al. 2018

Transl. Androl. Urol

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BackgroundThe prevalence of varicoceles is estimated to be 15% in the general population but is nearly 35% among men with primary infertility and increases by 10% with each decade of life. Studies among adults infer a higher rate of varicoceles among first-degree relatives of patients with varicoceles. However, these studies do not consider the presence of varicoceles, or other venous abnormalities, at the time of desired paternity in first-degree relatives of adolescent patients. Our aim was to document the prevalence of varicoceles and varicose veins among first-degree relatives of pediatric patients diagnosed with varicoceles.MethodsA series of 884 patients between the ages of 17 and 22 diagnosed with a varicocele were contacted and of the responders, permission was asked to discuss family history. Each patient underwent a telephone survey regarding the presence of a varicocele in the father prior to achieving paternity, the presence of a varicocele in brothers in childhood, or varicose veins in the father and mother prior to achieving pregnancy. If a varicocele or varicose vein was present, a history of intervention was surveyed. Descriptive statistics were performed to assess overall prevalence of varicocele and varicose veins in first-degree relatives. Chi-squared and logistic regression analyses were performed.ResultsIn total, 152 patients (17.2%) responded and 139 (91.4%) consented to the telephone survey (mean age 19.5±1.84 years old). Overall, 12.9% of fathers had varicoceles and 8.6% of fathers underwent surgical intervention. Among siblings, 18 individuals had a varicocele and 5.6% of siblings with varicocele required intervention. Varicose veins were diagnosed in 7.9% of fathers and 25.2% of mothers; 8.6% of mothers underwent intervention. Surveillance was employed in 76.3% of patients, and surgery undertaken 21.6%. Patients with grade 2 or 3 varicoceles were more likely to have a father with a varicocele than those with grade 1 varicocele (P=0.037). Patients with grade 2 varicocele were more likely to have a father who required varicocele surgery than grade 1 (P=0.019). There was no statistical association of adolescent varicocele and varicose veins in first degree relatives (P=0.306).ConclusionsThis series shows that while a father’s prevalence is similar to that of the general population, higher grade varicoceles were associated with a higher prevalence of varicoceles and surgical ligation. This suggests the existence of a hereditary predisposition to high grade varicoceles. Furthermore, varicocele is not associated with varicose veins in first degree relatives.

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“…14,29,54 Si bien debemos considerar que esta agrupación genética podría deberse no solo en exclusiva a factores genéticos sino también a factores ambientales, un estudio realizado en familias con hijos adoptados demostró una mayor prevalencia de EVC en hijos biológicos. 55,56 2. Introducción…”

Section: La Historia Familiarunclassified

“…Existen estudios que muestran una asociación estadísticamente significativa entre los antecedentes familiares de la enfermedad y el desarrollo y progresión de la misma. 55,123 En trombofilias hereditarias se ha determinado agregación familiar de la trombosis venosa profunda en pacientes con insuficiencia venosa crónica. 124 A favor de estos estudios, que consideran la existencia de factores genéticos que influyan en el desarrollo de varices, se encuentran nuestros resultados.…”

Section: Antecedentes Familiaresunclassified

Estudio del perfil ginecológico de pacientes portadoras de varices esenciales

Rodríguez¹

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Se diseña un estudio prospectivo en el cual se recogieron datos de pacientes del sexo femenino que se remitieron a la consulta externa del Servicio de Angiología y Cirugía Vascular (ACV) del Hospital Clínico Universitario de Valladolid para valoración del síndrome varicoso de extremidades inferiores, las cuales constituyeron el grupo caso (n= 503). El grupo control, estuvo constituido por pacientes mujeres que acudieron a la Consulta de ACV por un motivo diferente al de patología venosa. 1. Resumen Tesis doctoral María Azpeitia Rodríguez 20 1.2 ABSTRACT 1. Resumen Tesis doctoral María Azpeitia Rodríguez 21 1. Resumen Tesis doctoral María Azpeitia Rodríguez 22 There were also statistically significant differences in relation to the type of work situation associated with bipedestation (19.2% vs 26.5%, p = 0.027) or to sit (11.6% vs 13.9%, p = 0.41), nor in the prevalence of obesity (8.7% vs. 7.5%, p = 0.67). However, the situation was different with respect to the family history, where 32% of the patients reported the presence of this pathology in some family member compared to 18.6% in the control group (p <0.001). Regarding the gynecological factors analyzed, the patients with varicose pathology had a higher prevalence of menopause (43.5% vs 16.5%, p <0.001), however in the age of presentation we did not find differences (49.2 ± 3.1 vs 49.26 ± 3 years, p = 0.84). No differences in the age of menarche were observed either. If we have found differences both in the number of patients who report some pregnancy at some point in their lives (82% vs 59%, p <0.001) and in the number of pregnancies per patient (2.01 ± 1.03 vs 1.63 ± 0.89, p < 0.001). Finally, we emphasize that in our results we obtain a statistically significant difference (p <0.001) regarding the use of hormonal therapy. Finding 49.1% in the varicose group versus 25.3% in the control group. CONCLUSIONS Women with varicose pathology of the lower extremities treated in our country are characterized by the presence of a higher rate of varicose veins in the menopausal stage and having presented a higher number of pregnancies and children during their lifetime. The main predictors of development of varicose syndrome are the presence of menopause, number of term pregnancies and hormone replacement therapy.

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Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study

Cited by 7 publications

References 40 publications

J‐curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study

J‐curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study

The role of inheritance in the development of adolescent varicoceles

Estudio del perfil ginecológico de pacientes portadoras de varices esenciales

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