Familial thrombosis: inherited deficiency of antithrombin III.

Recurrent Thrombosis in a Patient with Factor XII Deficiency

“…We feel this case report of a patient with moderately decreased factor XII level and recurrent thrombosis focuses on the in vivo function of factor XII and in some respects parallels the documented enhanced throm bosis tendency in patients with moderate de creased antithrombin-III levels [9].…”

Chronic Inflammatory Bowel Disease, Deep-Venous Thrombosis and Antithrombin Activity

“…It would seem reason able to avoid use of the oestrogen-contain ing contraceptive pill, as this in itself had been shown to reduce AT 111 levels [ 12], I n familial thrombosis and AT III deficien cy, prophylactic warfarin treatment has been successful [6], but any potential ben efit would have to be weighed up against the considerable risk of haemorrhage in these patients with a known focus for bleeding. It would, therefore, be valuable to be able to predict which patients are particularly prone to thromboembolic events.…”

“…These observations were confirmed and extended in another study involving only 6 cases of ulcerative colitis and 6 cases of Crohn's disease [4], This study [4] in addition demonstrated increased plate let counts associated with abnormal plate let function and reduced levels of anti thrombin III (AT III) in patients with bowel disease. AT III deficiency, whether inherited [5,6] or acquired [7,8] has been linked with an increased risk of thrombosis. The principal aim of this study was to deter mine the status of AT III and related en zymes, « 2 macroglobulin (coM) and «|-antitrypsin («|AT), in our group of patients with CIBD and to correlate the results with the clinical activity of their disease and in particular with any evidence of thrombosis.…”

Mechanisms of Deep Vein Thrombosis: A Review

“…The hereditary deficiency or defect of antithrombin III is associated with major thromboembolic disease starting in adolescence or during the first pregnancy in women (Mackie et al 1978). The prompt neutralization of activated clotting factors is obviously of major importance in preventing stasis-induced thrombosis.…”