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) showed sensitivities of 90 and 88%, specificities of 42 and 44%, and NPV's of 85 and 83%, respectively. The Nycocard Ò D-dimer assay showed a sensitivity of 63%, specificity of 67% and NPV of 71%. Conclusions. The diagnostic performance of VIDAS New Ò and the Auto Dimer Ò D-dimer assays is almost identical, but this study suggests that neither of the D-dimer assays is suitable as the only screening method for DVT, in a situation with a high pretest probability of DVT. This call for a differential strategy that distinguishes between cases of low and high clinical probability using either a D-dimer test or ultrasonography.