Familial primary gastric lymphoma.

Hayoz, Daniel; Extermann, Martine; Odermatt, Bernhard; Pugin, P; Regamey, C; Knecht, Hans

doi:10.1136/gut.34.1.136

Cited by 6 publications

(7 citation statements)

References 26 publications

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“…Familial non‐Hodgkin's lymphoma (NHL) cases were collected from two sources: the published medical literature ( Camino, 1975; Greene & Miller, 1978; Shelley, 1980; Greene et al , 1982 ; Haim et al , 1982 ; Veltri et al , 1983 ; Kato et al , 1989 ; Lynch et al , 1992 ; Hayoz et al , 1993 ; Donadieu et al , 1996 ; James et al , 1998 ) from 1926 to the present; and our series of unpublished families with multigenerational NHL. Additional information on one of the published families was obtained by personal communication with the author ( James et al , 1998 ).…”

Section: Methodsmentioning

confidence: 99%

Age of onset evidence for anticipation in familial non‐Hodgkin's lymphoma

Wiernik

Wang

et al. 2000

Br J Haematol

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Summary. Anticipation, a phenomenon in which an inherited disease is diagnosed at an earlier age in each successive generation of a family, has been demonstrated in certain neurological and haematological disorders. This study was conducted to determine whether anticipation occurs in familial non-Hodgkin's lymphoma (NHL). Eleven published reports of multigenerational familial NHL were analysed for evidence of anticipation, together with 18 previously unreported families with familial NHL. Differences in disease-free survival between generations were determined. The difference between age at onset for each affected parent±child pair was tested against the null hypothesis that there was no difference in age at onset. These analyses were also performed separately using only parent± child pairs with age of onset > 25 years to avoid ascertainment bias. In addition, the age at onset distribution of the studied cases was compared with that of the Surveillance Epidemiology and End Results (SEER) Program using data for 1973±98. The median ages at onset in the child and parent generations of all families (48´5 and 71´3 years respectively) and in the selected pairs (52´5 and 71´5 years respectively) were signi®cantly different (P < 0´000002 and P < 0´000001 respectively). The null hypothesis was rejected for all (P < 0´000001) as well as selected pairs (P < 0´000003). A signi®cant difference was observed between the ages of onset of the child generation and the SEER population (P < 0´009), but not between the parent generation and the SEER population. Anticipation occurs in familial NHL, which suggests a genetic basis for it.

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Section: Methodsmentioning

confidence: 99%

Age of onset evidence for anticipation in familial non‐Hodgkin's lymphoma

Wiernik

Wang

et al. 2000

Br J Haematol

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“…Patients with congenital immunodeficiency syndromes, such as Chediak–Higashi syndrome, ataxia‐telangectasia, B‐cell lymphoproliferative syndrome, Bruton agammaglobulinemia, common variable immunodeficiency, and Wiscott–Aldrich syndrome, are known to be predisposed to lymphoma 1–4. Apart from these syndromes, familial aggregation of lymphoma has been reported repeatedly,1–3, 8–20 but few population‐based studies have been published. Some authors have proposed an autosomal dominant transmission of lymphoma,2, 6 but in most families the pattern of transmission is unclear.…”

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confidence: 99%

“…Some authors have proposed an autosomal dominant transmission of lymphoma,2, 6 but in most families the pattern of transmission is unclear. Patients with lymphoma are more likely than unaffected controls to have a positive family history of hematopoietic diseases 1–3, 8–10…”

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confidence: 99%

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The incidence of lymphoma in first-degree relatives of patients with Hodgkin disease and non-Hodgkin lymphoma

Paltiel¹,

Schmit²,

Adler³

et al. 2000

Cancer

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BACKGROUND The precise incidence of familial Hodgkin disease (HD) and non‐Hodgkin lymphoma (NHL) in first‐degree relatives is unknown. Through record linkage using two population‐based sources, the authors estimated the risk of HD and NHL in family members of lymphoma probands. METHODS The authors identified 8037 first‐degree relatives of 2606 lymphoma cases (28.5% HD, 71.5% NHL) treated between 1970 and 1993 in 3 hospitals in Israel via the family file of the Population Registry. The authors linked this file with the Israel Cancer Registry, then calculated the standardized incidence ratio (SIR) by dividing the observed number of cases with the expected, adjusting for age, gender, calendar year, and continent of origin. RESULTS The family file yielded incomplete ascertainment of relatives (for 771 probands, no relatives were identified). Twenty cases of lymphoma—6 HD and 14 NHL—were identified among relatives of lymphoma patients. The SIR for HD was 1.15 (95% confidence interval [CI]: 0.42–2.51) and for NHL 1.71 (95% CI: 0.93–2.87), considering the entire population of first‐degree relatives. SIRs among siblings of lymphoma probands were 3.12 (95% CI: 1.01–7.29) for HD, 2.16 (95% CI: 0.45–6.31) for NHL, and 2.68 (95% CI: 1.15–5.27) for all lymphomas. There were 4 HD/HD, 1 NHL/NHL, and 3 NHL/HD sibling pairs. For HD/HD and NHL/NHL sibling pairs, the interval between lymphoma occurrence in proband and sibling was 1–4 years, whereas for HD/NHL pairs this ranged from 16 to 21 years. CONCLUSIONS The risk of lymphoma among siblings of lymphoma probands was over 2.5‐fold that of the general population and lower among other family members. The temporal proximity of HD/HD and NHL/NHL sibling pairs argues for environmental as well as genetic etiology. This method was hampered by incomplete data. Cancer 2000;88:2357–66. © 2000 American Cancer Society.

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“…A population-based study in Israel among first-degree relatives of patients with lymphomas showed that only 0.7% of the lymphoma patients had a history of lymphoma in one or more relatives [ 2 ]. In some families, a pre-existing immune deficiency has been described [ 3 - 5 ]. No histological subtype appears to predominate in familial cases.…”

Section: Introductionmentioning

confidence: 99%

Familial Aggregation of Non-Hodgkin's Lymphoma (NHL). A Case Report

Loves

Haan

Daenen

2006

Hered Cancer Clin Pract

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A family is reported in which three male siblings of Asian descent developed non-Hodgkin's lymphoma (NHL). Case 1 was diagnosed with indolent follicular lymphoma stage IIIA at age 45. Case 2 presented with large B-cell lymphoma stage IIB at age 56. Chromosomal investigation of the peripheral blood did not show abnormalities. Chemotherapy induced a complete remission. However, after a period of nearly ten years he developed acute myeloid leukaemia. Case 3 developed large B-cell lymphoma stage IVA at age 52. Cytogenetic analysis in peripheral blood was normal. Shared genetic and environmental risk factors remain to be identified in this family. Familial aggregation of NHL is uncommon. In some families, various forms of immunodeficiency have been found. In addition to coincidental clustering of cases, and rare cases explained by known tumour syndromes such as Li-Fraumeni (like) syndrome, other familial cases may share as yet unknown genetic and/or environmental risk factors.

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Familial primary gastric lymphoma.

Cited by 6 publications

References 26 publications

Age of onset evidence for anticipation in familial non‐Hodgkin's lymphoma

Age of onset evidence for anticipation in familial non‐Hodgkin's lymphoma

The incidence of lymphoma in first-degree relatives of patients with Hodgkin disease and non-Hodgkin lymphoma

Familial Aggregation of Non-Hodgkin's Lymphoma (NHL). A Case Report

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