Familial occurrence of classical and idiopathic trigeminal neuralgia

Eide, Per Kristian

doi:10.1016/j.jns.2021.120101

Cited by 9 publications

(15 citation statements)

References 49 publications

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“…Evidence on the role of genetic factors in TN has increased recently. Although familial TN has been considered to be relatively rare, with prevalence rates ranging between 1%-2% [12,13], more recent evidence suggests that it may occur more frequently than previously assumed [12][13][14]27].…”

Section: Pathophysiology Of Tnmentioning

confidence: 97%

“…The role of epigenetic factors has also been highlighted by several experimental studies, with one reporting observation of peripheral inflammation-altered DNA methylation in rat trigeminal ganglia and consequent abnormal expression of pro-nociceptive genes [14]. Bai et al [26] suggested that trigeminal ganglia pro-nociceptive genes may be subject to epigenetic modulation via DNA methylation that regulates genes.…”

Section: Pathophysiology Of Tnmentioning

confidence: 99%

“…Eide PK [14] reported observing familial TN in 41 out of 268 (15.2%) Norwegian patients with idiopathic or classical TN. Gene mutations and voltage-gated ion channels, particularly sodium channels, have been examined by various human and experimental animal studies as sodium channel blockers are effective in TN patients [12,13].…”

Section: Pathophysiology Of Tnmentioning

confidence: 99%

“…The etiology, pathophysiology, diagnosis, and prognosis of TN has been extensively examined over the past decade [11], with more recent studies also focusing on gene mutations and familial incidence of the same [12][13][14]. These genetic studies have largely focused on genes coding voltagedependent ion channels as sodium channel blockers represent an effective treatment measure for TN [12,13].…”

Section: Introductionmentioning

confidence: 99%

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A Review of Recent Evidence on Trigeminal Neuralgia

Kim

2023

J Oral Med Pain

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This review aimed to update our knowledge of the classification, pathophysiology, prognosis, and treatment of trigeminal neuralgia (TN), with the intention of establishing better treatment protocols. The latest version of the International Classification of Headache Disorders uses an etiology-based approach to characterize TN patients, potentially contributing to the development of targeted treatment measures. Noticeable changes in the recent European Academy of Neurology guidelines for the management of TN include the use of magnetic resonance imaging for exclusion of secondary TN and differentiation of idiopathic and classical TN. Additionally, the use of botulinum toxin type A as an addon therapy for mid-term treatment of TN has also been included. Though there has been limited recent progress in the treatment of TN, previous studies emphasize the importance of customized, multidisciplinary management protocols that include drug therapy optimization; provision of continuous education and support; and timely referral of medically refractory patients for surgery in order to achieve favorable prognosis. Furthermore, slow but growing evidence on gene mutations will help elucidate the pathophysiology of TN and contribute to the development of targeted drugs that are effective and safe.

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Section: Pathophysiology Of Tnmentioning

confidence: 97%

Section: Pathophysiology Of Tnmentioning

confidence: 99%

Section: Pathophysiology Of Tnmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Review of Recent Evidence on Trigeminal Neuralgia

Kim

2023

J Oral Med Pain

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“…The pain usually lasts from a few seconds to a few minutes and may be so intense that it triggers involuntary wincing, hence the term tic. Most cases of TN are sporadic but familial forms exist and are likely to be underestimated [ 3 ]. In both situations, the etiology of TN remains largely unknown and neurovascular compression of the trigeminal root nerve represents the primary theory for the underlying cause of the disease.…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia

et al. 2022

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Trigeminal neuralgia (TN) is a rare form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face. While most cases occur in a sporadic manner and are accompanied by intracranial vascular compression of the trigeminal nerve root, alteration of ion channels has emerged as a potential exacerbating factor. Recently, whole exome sequencing analysis of familial TN patients identified 19 rare variants in the gene CACNA1H encoding for Cav3.2T-type calcium channels. An initial analysis of 4 of these variants pointed to a pathogenic role. In this study, we assessed the electrophysiological properties of 13 additional TN-associated Cav3.2 variants expressed in tsA-201 cells. Our data indicate that 6 out of the 13 variants analyzed display alteration of their gating properties as evidenced by a hyperpolarizing shift of their voltage dependence of activation and/or inactivation resulting in an enhanced window current supported by Cav3.2 channels. An additional variant enhanced the recovery from inactivation. Simulation of neuronal electrical membrane potential using a computational model of reticular thalamic neuron suggests that TN-associated Cav3.2 variants could enhance neuronal excitability. Altogether, the present study adds to the notion that ion channel polymorphisms could contribute to the etiology of some cases of TN and further support a role for Cav3.2 channels.

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The omega of TRPM7 channels in trigeminal neuralgia

Weiss

Zamponi

2022

Pflugers Arch - Eur J Physiol

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Familial occurrence of classical and idiopathic trigeminal neuralgia

Cited by 9 publications

References 49 publications

A Review of Recent Evidence on Trigeminal Neuralgia

A Review of Recent Evidence on Trigeminal Neuralgia

Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia

The omega of TRPM7 channels in trigeminal neuralgia

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