Familial Neonatal Leukaemia

Campbell, Winston A.; Macafee, A. L.; Wade, WilloughbyF.

doi:10.1136/adc.37.191.93

Cited by 25 publications

(4 citation statements)

References 8 publications

(7 reference statements)

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“…The majority of non lymphocytic type found (80%), while ALL comprises only less than 20%. Familial neonatal leukemia is extremely rare and no child born to a mother with leukemia has been found to have the disease during the neonatal period [29]. Clinical signs of leukemia may be evident at birth with hepatosplenomegaly, petechiae and ecchymosis.…”

Section: Discussionmentioning

confidence: 99%

Congenital Acute Lymphoblastic Leukemia: A Rare Presentation in a One Month Old Boy

Khaleque¹

2014

Pediat Therapeut

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A one month old boy of non-consanguineous parents was admitted with gradual distension of abdomen, yellow coloration of whole body, progressive pallor and respiratory distress since birth. Septic investigations were done and found negative. His complete blood count with peripheral blood film examination revealed hyperleukocytosis, thrombocytopenia and presence of significant number of blasts cell. Cerebrospinal fluid (CSF) examination showed central nervous system (CNS) status 3(≥5 WBC/cmm 3 with blasts). Other causes of leukemoid reaction were ruled out. Karyotyping had done and found normal chromosomal pattern (46XY). Bone marrow aspiration findings were suggestive of ALL-L 1 .His myeloperoxidase (MPO) and Sudan black stain was negative but Periodic acid schiff (PAS) stain was positive. Immunophenotype showed blasts cells which were positive for CD5(1.10%), CD8(0.4%), CD10(0.74%), CD13(13.7%) and CD19(62.4%). Finally, the boy was diagnosed as congenital acute lymphoblastic leukemia (ALL-L 1 , B-lineage, CNS status 3). Following chemotherapy, the child suddenly deteriorated and on the second day of therapy suddenly he expired possibly due to leukostasis or coagulopathy or non responsive of drugs or MLL gene translocation.So, congenital acute lymphoblastic leukemia (CALL) should be kept in mind in a newborn child with clinical features of sepsis, leukocytosis, thrombocytopenia, huge hepatosplenomegaly.

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Section: Discussionmentioning

confidence: 99%

Congenital Acute Lymphoblastic Leukemia: A Rare Presentation in a One Month Old Boy

Khaleque¹

2014

Pediat Therapeut

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“…[ 11 ] Children may present with a broad variety of atypical symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions. [ 12 ] The clinical signs of leukemia may be evident at birth with hepatosplenomegaly, petechiae and ecchymosis. [ 11 ] Leukemia cutis is less common.…”

Section: Discussionmentioning

confidence: 99%

Congenital acute megakaryocytic leukemia

Mathur

Jain

Singh

et al. 2011

Indian Journal of Medical and Paediatric Oncology

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Congenital leukemia (CL) is an extremely rare disorder in the newborn, significant proportion of which is of myeloid origin, primarily of M4 or M5 morphology. As compared to pediatric leukemia, CL is a more aggressive disease. Acute myeloid leukemia (AML-M7) or acute megakaryocytic leukemia is a rare type of AML with an incidence of 0.5 per million per year. Median age of presentation is 6 years, and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions.

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“…Among the children with Down's syndrome combined with acute leukaemia, however, in several cases the leukaemia was either present at birth or had its onset during the first year of life [lo]. Among the few families with several cases in the same sibship, one is reported [2] in which 3 out of 5 siblings were shown to have the disease already during the first few months of life.…”

Section: High Concordance Rates In Leukaemia In Monovular Twins An Imentioning

confidence: 99%