A one month old boy of non-consanguineous parents was admitted with gradual distension of abdomen, yellow coloration of whole body, progressive pallor and respiratory distress since birth. Septic investigations were done and found negative. His complete blood count with peripheral blood film examination revealed hyperleukocytosis, thrombocytopenia and presence of significant number of blasts cell. Cerebrospinal fluid (CSF) examination showed central nervous system (CNS) status 3(≥5 WBC/cmm 3 with blasts). Other causes of leukemoid reaction were ruled out. Karyotyping had done and found normal chromosomal pattern (46XY). Bone marrow aspiration findings were suggestive of ALL-L 1 .His myeloperoxidase (MPO) and Sudan black stain was negative but Periodic acid schiff (PAS) stain was positive. Immunophenotype showed blasts cells which were positive for CD5(1.10%), CD8(0.4%), CD10(0.74%), CD13(13.7%) and CD19(62.4%). Finally, the boy was diagnosed as congenital acute lymphoblastic leukemia (ALL-L 1 , B-lineage, CNS status 3). Following chemotherapy, the child suddenly deteriorated and on the second day of therapy suddenly he expired possibly due to leukostasis or coagulopathy or non responsive of drugs or MLL gene translocation.So, congenital acute lymphoblastic leukemia (CALL) should be kept in mind in a newborn child with clinical features of sepsis, leukocytosis, thrombocytopenia, huge hepatosplenomegaly.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.