Familial Mediterranean Fever, Amyloidosis and Pregnancy

Abstract

Summary: A case of pregnancy in an Armenian with pre‐existing familial Mediterranean fever and amyloidosis is presented and discussed. The patient's renal function showed marked permanent deterioration in association with the pregnancy, and the infant, although premature, was “small for dates”.

Successful Full-Term Pregnancy in Familial Mediterranean Fever Complicated with Amyloidosis: Case Report and Review of the Literature

“…Enhanced urinary excretion of transferrin may produce an iron-resistant microcytic, hy pochromic anemia in the nephrotic syndrome [14], which was apparent in the present case as in 4 other reports [10][11][12][13].…”

“…Kidney amyloidosis usually leads to severe renal damage and nephrotic syndrome may be one of its major manifestations [2], Preg nancy in patients with a long-standing ne phrotic syndrome may be associated with un favorable maternal and fetal prognosis [8,9], Since the first report in 1967 by Sohar et al [7], only 4 additional authors [10][11][12][13] have reported their experience with an amyloid osis-related nephrotic syndrome and pregnan cy. Three of them [3,10,11] describe FMF amyloidosis.…”

“…Three of them [3,10,11] describe FMF amyloidosis. In one study [12] the amyloid osis is not specified and in another report amyloidosis was secondary to tuberculosis [ 13].…”

“…Some of these patients also suffer from skin lesions and arthritis. Amyloidosis may complicate up to 2 5 % of FMF patients [ 1 ] and in these patients several kinships with autosomal dominant in heritance were reported [2], [10] et al [12] Pfanner [11] and Levin [13] uterus, tubes and ovaries was also reported [4]. During pregnancy, FMF bouts usually lessen [5,6], However, a 30% fetal wastage was reported [5].…”