Familial macular cone dystrophy: diagnostic value of multifocal ERG and two-color threshold perimetry

Kretschmann, Ulf; Stilling, R K; Rüther, Klaus; Zrenner, Eberhart

doi:10.1007/s004170050255

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…19 The P1 amplitude of the central fovea is believed to be linked to the number and function of photoreceptor cells 1819 Our observation that the pre-AMD or early AMD eyes have a lowered P1 amplitude than their fellow eyes and the normal eyes is consistent with the hypothesis that the AMD eyes may have a reduced number and/or functional deficiency of photoreceptors. According to Kondo et al , the negative and positive deflections in the first order kernel of MERG probably do not correspond to conventional a and b-waves of ERG 20.…”

Section: Discussionsupporting

confidence: 60%

Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration

2001

British Journal of Ophthalmology

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Aim-To explore the use of multifocal electroretinograms (MERG) in detecting early changes in age related macular degeneration (AMD). Method-15 pre-AMD or early AMD eyes showing retinal drusen or irregular fundus pigmentation with window defects by fluorescein angiography (FA) and mildly decreased visual acuity were examined and compared with their asymptomatic fellow eyes. 20 age matched normal eyes were included as controls. MERG was recorded by a Veris system (version 3.0) using a 103 hexagon stimulus and 218 second total recording time per eye. The first order kernel was used to calculate amplitudes and latencies in three configurations: the nasal and the temporal areas, the superior and the inferior areas, and six concentric rings centred on the fovea. Results-There were no significant diVerences in the amplitudes and the latencies between the diVerent regions (nasal versus temporal and superior versus inferior) of the retina as well as between the diVerent groups of eyes (normal, pre-AMD or early AMD, and the asymptomatic fellow eyes) in each region. Using the concentric configuration, the foveal amplitude of pre-AMD or early AMD eyes was significantly suppressed when compared with the age matched control group and their average latency was longer in the fovea than in outer rings and significantly prolonged when compared with the normal control group. Similar changes in amplitude and latency were also observed in the asymptomatic fellow eyes. Conclusion-Significant abnormality in the foveal amplitude and the foveal latency of MERG could be detected in pre-AMD or early AMD eyes as well as their asymptomatic contralateral eyes, suggesting MERG as a sensitive tool in detecting early foveal abnormalities in AMD. (Br J Ophthalmol 2001;85:287-290) Normal ageing retinas exhibit a spectrum of changes such as decreased density of foveal photoreceptors and retinal pigment epithelial (RPE) cells while age related macular degeneration (AMD) retinas display similar losses, with or without subretinal neovascularisation, including atrophy of the pigment epithelium but with drusen as an early indicator.

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Section: Discussionsupporting

confidence: 60%

Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration

2001

British Journal of Ophthalmology

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“…80,93,131,149,152,154,169,282 The main mfERG findings in patients with cone dystrophy include severe reductions in response amplitudes with delays in implicit times or complete absence of mfERG responses, especially in the central retina. 93,131,152,154,169,282 Holopigian et al evaluated both the cone-and rod-mediated mfERG in patients with cone dystrophy. 93 It was shown that patients had large reductions in cone-mediated mfERG amplitude and delays in implicit time which were more marked in the central retina.…”

Section: Cone Dystrophy and Occult Macular Dystrophymentioning

confidence: 99%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Lai

Chan

Lai

et al. 2007

Survey of Ophthalmology

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Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

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“…Die Diagnose einer Zapfendystrophie, bei der häufig keine ophthalmoskopisch erkennbare Netzhautveränderung vorliegt, ist nur elektrophysiologisch zu objektivieren. Subjektiv sind in der Farbperimetrie typische Funktionsausfälle nachweisbar [7], die bei einer psychogenen Störung nicht zu erwarten wären. Das Ganzfeld-ERG erlaubt die Aufdeckung generalisierter Dystrophien oder Funktionsbeeinträchtigungen der Netzhaut.…”

Section: Diskussionunclassified

Foveale Zapfendystrophie: Diagnostischer Stellenwert des multifokalen Elektroretinogramms

Hübsch¹,

Gräf²

2002

Klin Monatsbl Augenheilkd

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Familial macular cone dystrophy: diagnostic value of multifocal ERG and two-color threshold perimetry

Cited by 9 publications

References 8 publications

Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration

Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Foveale Zapfendystrophie: Diagnostischer Stellenwert des multifokalen Elektroretinogramms

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