Familial Colorectal Cancer

Abstract

Cancers of the colon and rectum are among the leading causes of cancer deaths worldwide, accounting for 1 million new cases in 2002 and representing 9.4% of the world total. 1 In 2006, more than 148 000 new cases were diagnosed in the United States, accounting for 10.4% of all cancers. 2 Despite the increased use of screening strategies to identify early stage, more curable colorectal cancers and the availability of novel therapeutic agents, more than one-third of patients with colorectal cancer will eventually die of uncontrolled metastatic spread within a few years of diagnosis. In 2006, 55 000 individuals died of colorectal cancer in the United States, which established colorectal cancer as the second leading cause of cancer deaths for men and the third for women. 2

Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the ApcMin/+ model of colon cancer

“…Colon cancer is major public health concern with over 130 000 new cases diagnosed every year and over 50 000 deaths in the United States alone. 1 While many factors including diet and genetics influence colon cancer progression, 2 expression of thrombospondin-1 (TSP1) inversely correlates with colon cancer aggressiveness. 3 , 4 TSP1 is a matricellular protein that regulates tissue perfusion, platelet aggregation, angiogenesis, and responses to stress.…”