Survival After Colorectal Cancer Diagnosis Is Associated with Colorectal Cancer Family History

Zell, Jason A.; Honda, Jane; Ziogas, Argyrios; Anton‐Culver, Hoda

doi:10.1158/1055-9965.epi-08-0587

Cited by 31 publications

(53 citation statements)

References 40 publications

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“…Published studies focusing on the prognostic importance of family history in CRC are few [15][16][17][18][19][20][21]. Previous studies have revealed better survival for those with a positive family history in four studies [15,16,19,21], a worse survival in two [17,18], and no survival difference in one [20].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed better survival for those with a positive family history in four studies [15,16,19,21], a worse survival in two [17,18], and no survival difference in one [20]. The study design varied with three studies registerbased [15,17,19] and four a prospective observational studies [16,18,20,21]. Two studies analyzed females only [18,21], one only colon cancer [17] and none confirmed the diagnosis of the relatives with histological reports.…”

Section: Discussionmentioning

confidence: 99%

“…Two studies analyzed females only [18,21], one only colon cancer [17] and none confirmed the diagnosis of the relatives with histological reports. The studies also varied in which way the positive family history was defined, five studies included only first degree relatives [16,[18][19][20][21] and two studies first to third degree relatives [15,17]. For those including just first degree relatives three of the studies did not include the offspring [16,18,21] and one study excluded HNPCC [19].…”

Section: Discussionmentioning

confidence: 99%

“…The interest in the relations between a family history of CRC and survival has apparently increased as four of the seven studies are published in 2008 [16,18,19,21]. Because the results are contradictory and the studies have different designs, there is still some uncertainty about the association of family history with the prognosis of patients with CRC.…”

Section: Discussionmentioning

confidence: 99%

“…The pathological prognostic factor of most importance is the disease (TNM) stage, moreover blood or lymphatic vessel invasion and the differentiation grade have prognostic implication [13,14]. Studies on whether patients with CRC and a positive family history for CRC have better or worse prognosis are sparse and the results are contradictory [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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The correlation between a family history of colorectal cancer and survival of patients with colorectal cancer

et al. 2009

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The purpose was to analyze survival of patients with colorectal cancer and a positive family history for colorectal cancer in first degree relatives compared with those with no such family history and to determine whether differences in survival could be explained by known clinico-pathological factors. During 2000-2003, 318 consecutive patients with colorectal cancer answered a written questionnaire about their family history for colorectal cancer. During a 6-year follow-up, recurrences and survival were registered. Thirty-one (10%) patients had a first-degree relative with colorectal cancer, moreover two patients fulfilled the criteria of hereditary non-polyposis colorectal cancer and were excluded. Patients with a first-degree relative with colorectal cancer had better survival and lower risk for recurrences compared to those with no relatives with colorectal cancer. In a multivariate analysis including age, gender, stage of disease, tumor differentiation, vascular invasion and family history, patients with first-degree relatives with colorectal cancer had lower risks for death (RR 0.37; 95% CI 0.17-0.78) and death from cancer (RR 0.25; 95% CI 0.08-0.80), compared to those with a no relative with colorectal cancer. The differences were seen in patients with colon cancer but not rectal cancer. Family history for colorectal cancer in a first-degree relative is an individual prognostic factor in patients with colon cancer and could not be explained by known clinico-pathological factors. The value of family history taking in patients with colon cancer is therefore not only to identify families with hereditary colorectal cancer, but also to add information to the prognosis of the patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The correlation between a family history of colorectal cancer and survival of patients with colorectal cancer

et al. 2009

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Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies

et al. 2018

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A family history of colorectal cancer (CRC) in first‐degree relatives (FDRs) increases the risk of CRC. However, the influence of family history on survival among CRC patients remains unclear. We conducted a pooled analysis of survival in 5010 incident CRC cases. Cox proportional hazards models were used to estimate the association of family history with overall survival (OS) and CRC‐specific survival (CSS). We also assessed the impact of the number of affected FDRs and age at CRC diagnosis in the affected FDRs on survival. Among CRC cases, 819 (16%) patients reported a family history of CRC. There were 1580 total deaths over a median follow‐up of 4.6 years, of which 1046 (66%) deaths were due to CRC. Having a family history of CRC was not associated with OS [hazard ratio (HR), 1.03; 95% confidence interval (CI), 0.89–1.19] or CSS (HR, 1.13; 95% CI, 0.95–1.36)]. There were no associations between the number of affected relatives or age at CRC diagnosis of the affected relative with survival (all P trend > 0.05). However, a family history of CRC did confer worse CSS in patients diagnosed with distal colon cancer (HR, 1.45, 95% CI, 1.03–2.04). A family history of CRC was generally not associated with survival after CRC diagnosis. However, having a family history of CRC was associated with worse CRC prognosis in individuals with distal colon cancer, suggesting a possible genetic predisposition with distinct pathogenic mechanism that may lead to worse survival in this group.

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Nonsteroidal anti‐inflammatory drugs

Zell

Ziogas

Bernstein

et al. 2009

Cancer

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BACKGROUND: Nonsteroidal anti‐inflammatory drug (NSAID) use has been associated with a decreased colorectal cancer (CRC) risk. However, to the best of the authors' knowledge, the effects of NSAID on clinical outcomes after CRC diagnosis are not well defined. The authors investigated the association between prediagnosis NSAID use and mortality after CRC diagnosis among women in the California Teachers Study cohort. METHODS: Women aged <85 years participating in the California Teachers Study, without a prior CRC diagnosis at baseline (1995‐1996), and who were diagnosed with CRC during follow‐up through December 2005, were eligible for analysis of the association between prediagnosis NSAID use and mortality. NSAID use (including aspirin and ibuprofen) was collected through a self‐administered questionnaire. Cancer occurrence was identified through California Cancer Registry linkage. Multivariate Cox proportional hazards regression models were used to estimate hazards ratios (HR) for death and 95% confidence intervals (95% CIs). RESULTS: Among 621 CRC patients who were identified, 64% reported no prediagnosis regular NSAID use, 17% reported use of 1 to 6 days/week, and 20% reported daily use. A duration of NSAID use <5 years was reported by 17% of patients and a use of ≥5 years was reported by 18%. Regular prediagnosis NSAID use (1‐3 days/week, 4‐6 days/week, and daily) versus none was associated with improved overall survival (OS) (HR, 0.71; 95% CI, 0.53‐0.95) and CRC‐specific survival (HR, 0.58; 95% CI 0.40‐0.84) after adjustment for clinically relevant factors. Prediagnosis NSAID use ≥5 years (vs none) was found to be associated with improved OS (HR, 0.55; 95% CI, 0.37‐0.84) and CRC‐specific survival (HR, 0.40; 95% CI, 0.23‐0.71) in adjusted analyses. CONCLUSIONS: When used regularly or over a prolonged duration before CRC diagnosis, NSAIDs are associated with decreased mortality among female CRC patients. Cancer 2009. © 2009 American Cancer Society.

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Survival After Colorectal Cancer Diagnosis Is Associated with Colorectal Cancer Family History

Cited by 31 publications

References 40 publications

The correlation between a family history of colorectal cancer and survival of patients with colorectal cancer

The correlation between a family history of colorectal cancer and survival of patients with colorectal cancer

Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies

Nonsteroidal anti‐inflammatory drugs

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