Familial colon cancer in the Tel-Aviv area and the influence of ethnic origin

Rozen, Paul; Lynch, Henry T.; Figer, Arié; Rozen, Shulamit; Fireman, Zvi; Legum, Cyril; Katz, L.M.; Moy, Alan; Kimberling, William J.; Lynch, Jane F.; Watson, Patrice

doi:10.1002/1097-0142(19871101)60:9<2355::aid-cncr2820600940>3.0.co;2-r

Cited by 38 publications

(16 citation statements)

References 14 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A further limitation is the lack of information on family history. We do know from a previous study, that familial CRC was more commonly found in the non-Ashkenazi CRC patients [4]. So, this cannot explain the higher risk for CRC in the European-Americanborn Jews.…”

Section: Discussionmentioning

confidence: 83%

“…They include the occurrence of low penetrance susceptibility mutations, uncommon and unrecognized dominant mutations and especially diet and lifestyle [4,5,[14][15][16][17]. The converse findings in Israeli born are, again, speculative.…”

Section: Discussionmentioning

confidence: 99%

“…Although these two malignancies share several etiological factors as well as treatment modalities, they differ markedly in morbidity trends. Historically, Ashkenazi (European) Jews, as compared to non-European Jews and non-Jews, have been noted to be at increased risk for CRC, this is attributed to different genetic susceptibility and/or lifestyle and diet [1][2][3][4][5]. The aims of this study were to follow Israeli long-term trends in CRC incidence and mortality and their associations with ethnicity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations

2004

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations

2004

Self Cite

View full text Add to dashboard Cite

show abstract

“…Rozen et al [42] investigated the family history of colon cancer in 38,823 individuals (2,129 families) as part of a case-control patient series from Tel-Aviv, Israel, and surrounding locations. There was a significant increased risk for CRC among first-degree relatives of patients affected with CRC compared to controls.…”

Section: Familial Crc In Israelmentioning

confidence: 99%

“…. .set the stage for laboratory-oriented, epidemiologic studies, which might then enable us to extract the crucial components of genetic-environmental interaction in colon carcinogenesis through focusing attention on groups that are distinguished by high, familial clustering of cancer [46][47][48][49][50]'' (cited by Rozen et al [42]). …”

Section: Familial Crc In Israelmentioning

confidence: 99%

Cancer in Jews: introduction and overview

Lynch

Rubinstein²,

Locker

2004

Familial Cancer

Self Cite

View full text Add to dashboard Cite

This article is based upon a literature overview of cancer in Jews. It involves a comparison of variation in incidence and prevalence rates between Jews and non-Jews. However, the reader must exercise a certain amount of skepticism when considering secular changes in cancer incidence and prevalence and the public health implications of such cancer variation. Ashkenazi Jews have a lifetime CRC risk of 9--15%. This elevated CRC risk is similar to that of individuals in the "familial risk'' category, and differs strikingly from the 5-6% CRC risk for non-Ashkenazi members of general Western populations. A MedLine search tested the hypothesis that site-specific and/or all-cancer incidence and mortality rates are either higher or lower than expected in Ashkenazi Jews worldwide, when compared with reference populations. Results showed that all cancer incidence and mortality is not higher in Ashkenazi Jews when compared to North American non-Hispanic whites. Indeed, rates for some cancers, such as carcinoma of the lung in Ashkenazi males, are low; this example is likely attributable in large part to decreased tobacco use. Carcinoma of the ovary, pancreas, stomach, and non-Hodgkin's lymphoma have a higher incidence rate in Ashkenazi. Even though BRCA1 and BRCA2 founder mutations which predispose to carcinoma of the breast and ovary appear increased in Ashkenazi breast cancer affected women, there was no evidence supporting an elevated risk of breast cancer among Ashkenazi women. Our primary concern, however, is that Ashkenazi Jews may have one of the highest lifetime CRC risks of any ethnic group in the world, a risk that diverges significantly from that of the general population; therein, it logically calls for more intensive CRC screening guidelines. We have emphasized that the reader use caution in the interpretation of statistics which portray variation in incidence and prevalence figures for cancer in any racial, ethnic, or religious group, inclusive, of course, of Jews. Clearly, more research will be required in the interest of accuracy in the understanding of these cancer variations, since they portend the need for special cancer control strategies. A lesser degree of attention can then be given to carcinoma of the penis and uterine cervix, which occur very infrequently in Jews. We urge our colleagues to continue to probe further into these statistical differences in cancer's incidence and prevalence in order to garner a better understanding of cancer's etiology and pathogenesis.

show abstract

Familial risk and colon cancer

Burt

1996

Int. J. Cancer

View full text Add to dashboard Cite

Familial occurrence in excess of that expected by chance is common among cases of colon cancer. Only a small fraction of these familial cases arise from well-described syndromes. There are epidemiologic, colonoscopic, genealogic data base and large prospective studies that characterize the familial occurrence and risk for common colon cancer. Kindred studies suggest that common familial occurrence arises from inherited susceptibility of a mild to moderate magnitude. The responsible genes are yet to be identified, though a number of candidate genes have been suggested. Clinical features, especially age at diagnosis and number of first-degree relatives with colon cancer, already allow stratification of familial risk. Risk stratification is important for colon cancer screening, as some higher-risk persons should probably have more intensive screening. Research is needed to identify the genes or their polymorphisms that give rise to common inherited susceptibility for colon cancer, to examine how susceptibility genes interact with environmental factors and give rise to colonic neoplasms and to verify suggested screening approaches that incorporate familial risk.

show abstract

Familial colon cancer in the Tel-Aviv area and the influence of ethnic origin

Cited by 38 publications

References 14 publications

Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations

Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations

Cancer in Jews: introduction and overview

Familial risk and colon cancer

Contact Info

Product

Resources

About