Cancer in Jews: introduction and overview

Abstract

This article is based upon a literature overview of cancer in Jews. It involves a comparison of variation in incidence and prevalence rates between Jews and non-Jews. However, the reader must exercise a certain amount of skepticism when considering secular changes in cancer incidence and prevalence and the public health implications of such cancer variation. Ashkenazi Jews have a lifetime CRC risk of 9--15%. This elevated CRC risk is similar to that of individuals in the "familial risk'' category, and differs strikingly from the 5-6% CRC risk for non-Ashkenazi members of general Western populations. A MedLine search tested the hypothesis that site-specific and/or all-cancer incidence and mortality rates are either higher or lower than expected in Ashkenazi Jews worldwide, when compared with reference populations. Results showed that all cancer incidence and mortality is not higher in Ashkenazi Jews when compared to North American non-Hispanic whites. Indeed, rates for some cancers, such as carcinoma of the lung in Ashkenazi males, are low; this example is likely attributable in large part to decreased tobacco use. Carcinoma of the ovary, pancreas, stomach, and non-Hodgkin's lymphoma have a higher incidence rate in Ashkenazi. Even though BRCA1 and BRCA2 founder mutations which predispose to carcinoma of the breast and ovary appear increased in Ashkenazi breast cancer affected women, there was no evidence supporting an elevated risk of breast cancer among Ashkenazi women. Our primary concern, however, is that Ashkenazi Jews may have one of the highest lifetime CRC risks of any ethnic group in the world, a risk that diverges significantly from that of the general population; therein, it logically calls for more intensive CRC screening guidelines. We have emphasized that the reader use caution in the interpretation of statistics which portray variation in incidence and prevalence figures for cancer in any racial, ethnic, or religious group, inclusive, of course, of Jews. Clearly, more research will be required in the interest of accuracy in the understanding of these cancer variations, since they portend the need for special cancer control strategies. A lesser degree of attention can then be given to carcinoma of the penis and uterine cervix, which occur very infrequently in Jews. We urge our colleagues to continue to probe further into these statistical differences in cancer's incidence and prevalence in order to garner a better understanding of cancer's etiology and pathogenesis.

MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population

“…It is noteworthy that the Chinese (and Japanese) population contains a higher frequency of people with the G genotype (this report and refs 37,38), which correlates with a higher percentage of them being predisposed to early onset of sporadic breast cancers (6). However, there have been no reports associating the G allele with general breast cancer risk in other populations (34,35,38,43).…”

“…However, the G/G genotypic frequency was more abundant-up to 24%-in the healthy Azhkenazi Jewish population (30), who are generally thought to have a higher lifetime cancer risk (37). Consistently, some reports have noted an increase in the frequency of this genotype with accelerated age of onset in Caucasian populations, suggesting that this genotype could be associated with cancer risk (28,30).…”

Expression of P53, P27 and KI‐67 in colorectal cancer patients of various ethnic origins: Clinical and tissue microarray based analysis

“…Several studies described genetic mutations in AJ with CRC [42][43][44]. The most common genetic derangement is the I1307K polymorphism of the APC gene, carried by 6-8% of the Ashkenazi Jewish population.…”

Unusually small sex differentials in mortality of Israeli Jews: What does the structure of causes of death tell us?

“…Perhaps the strongest arguments were in relation to the high prevalence of genes predisposing to certain types of cancer among Jews (Feldman 2001, Shkolnikov et al 2004, Lynch, Rubinstein, and Locker 2004. Genetic arguments exist also in relation to alcohol intolerance in Jews (Hasin et al 2002).…”

“…Manor et al (2000Manor et al ( , 2004, Eisenbach (1994) and Friedlander, Schellekens, and Sharashov-Cohen (1995) demonstrated the lasting nature of elevated mortality in the African-born females. Breast cancer among Israeli females was shown to be relatively high at many (but not all) points in time (Althuis et al 2005 (Feldman 2001, Lynch, Rubinstein, and Locker 2004, Rubinstein 2004). These genes may cause elevated risks of breast and ovarian cancer in females and prostate cancer in males.…”