Familial clustering of polymorphic light eruption in relatives of patients with lupus erythematosus: evidence of a shared pathogenesis

Abstract

The high prevalence of PLE in LE patients, together with clustering of PLE among first-degree relatives of SCLE and DLE probands, suggests that there may be a shared pathogenetic basis for PLE and cutaneous LE. We propose that predisposition to PLE may contribute to the LE phenotype in otherwise susceptible individuals.

UVB‐induced leucocyte trafficking in the epidermis of photosensitive lupus erythematosus patients: Normal depletion of Langerhans cells

“…It may even be expected that PLE and LE share common photopathogenic mechanisms. In a retrospective study among 85 SCLE and CDLE patients, Millard et al (8) found a high prevalence of PLE.…”

Characterization of clinical photosensitivity in cutaneous lupus erythematosus

“…These reactions, however, often occurred immediately after sun exposure, resolved within one day and rarely occurred in the absence of CLE-specific PS reactions. Because these reactions differ from PMLE in timing and setting, these findings suggest that PMLE-like reactions may occur as part of a photosensitivity spectrum in lupus 16 rather than PMLE as a co-occurring disorder 28, 29 .…”

Tissue Injury and the Skin

“…Carriers and patients with certain hereditary disorders such as X-linked and autosomal-recessive chronic granulomatosis disease and non-X-linked hyperimmunoglobulin M syndrome have an increased risk of developing CLE [128,129], indicating that the genes affected in the above disorders could be involved in the pathogenesis of CLE. Furthermore, patients with SCLE and DLE exhibit a high prevalence of additional PLE, suggesting a common genetic background [130,131]. The methodological approach to studying the genetic base of CLE has relied on association studies, family linkage analysis, and transmission equilibrium testing.…”