Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis

Hjalgrim, Henrik; Rasmussen, Søren; Rostgaard, Klaus; Nielsen, Nete Munk; Koch‐Henriksen, Nils; Munksgaard, Lars; Storm, Hans H.; Melbye, Mads

doi:10.1093/jnci/djh135

Cited by 51 publications

(50 citation statements)

References 23 publications

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“…on May 10, 2018. by guest www.bloodjournal.org From assessed among matched control subjects using the same hospital discharge registries, underdiagnosis of autoimmune and related disorders in subjects or their first-degree relatives should be nondifferential between patients and control subjects, and thus any bias should have been conservative, that is, toward a null association. 35,36 Another limitation is the large number of tested autoimmune and related conditions, which implies that one has to interpret detected associations with caution due to multiple comparisons.…”

Section: Discussionmentioning

confidence: 99%

Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries

Landgren

Engels

Caporaso

et al. 2006

Blood

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A population-based case-control study was conducted to evaluate risk of developing chronic lymphocytic leukemia (CLL) associated with personal and/or family history of autoimmune and related diseases. Data were obtained for all (n ‫؍‬ 7764) patients diagnosed with CLL in Sweden and Denmark over a 40-year period and with linkable relatives, 16 658 matched control subjects, and first-degree relatives of patients (n ‫؍‬ 17 991) and control subjects (n ‫؍‬ 39 388). Odds ratios (ORs) were calculated to quantify risk of CLL in relation to personal/family history of 32 autoimmune and related disorders. The risk of CLL was significantly increased among subjects with a personal history of pernicious anemia (OR ‫؍‬ 1.94; 1.18-3.18), mainly in the 0-to 1-year latency period. A significantly decreased risk of CLL was found among individuals with a personal history of chronic rheumatic heart disease (OR ‫؍‬ 0.55; 0.33-0.93), particularly persons with a long latency (10؉ years) between the 2 conditions. We found no association between personal or familial occurrence of other autoimmune or related disorders and CLL. If our results are confirmed, mechanistic studies examining how pernicious anemia might promote increased occurrence of CLL and how chronic rheumatic heart disease protects against CLL, perhaps related to long-term antibiotics use, may provide insights to the as-yet-unknown etiology of CLL. (Blood. 2006;108:292-296)

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Section: Discussionmentioning

confidence: 99%

Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries

Landgren

Engels

Caporaso

et al. 2006

Blood

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“…Ratios of the incidence of breast cancer in women with MS to that in women without MS served as measure of the relative risk (RR). Analyses were carried out using the proc GENMOD procedure in SAS, and adjustment was made for age (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) , . .…”

Section: Registersmentioning

confidence: 99%

“…As reported previously, we found no increased risk of haematopoietic and lymphatic cancers in the cohort. 17 Men with MS were at statistically significantly reduced risk of cancer overall (SIR 5 0.84 (0.76-0.93), n 5 361], reflecting low risk of cancers of the digestive and respiratory systems and the genital organs (Table I) (Table II). (Table III).…”

Section: Registersmentioning

confidence: 99%

“…[12][13][14] Overall, MS patients do not seem to be at an increased risk of developing neither cancer in general, nor Hodgkin lymphoma in particular, [15][16][17] but increased risks of breast cancer, 15,16 cancers of the CNS, 16,18 the urinary tract system 16 and nasopharynx 16 have been suggested. Typically such observations have been based on a small number of cases, rendering the risk estimates statistically imprecise.…”

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confidence: 99%

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Cancer risk among patients with multiple sclerosis: A population‐based register study

Nielsen

Rostgaard

Rasmussen

et al. 2005

Intl Journal of Cancer

122

144

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Cancer occurrence in patients with multiple sclerosis (MS) has been little studied, but associations with brain tumours, breast cancer, Hodgkin lymphoma and nasopharyngeal carcinoma have been suggested. We took advantage of population-based registers of MS and cancer to assess the risk of cancer following diagnosis of MS. Patients registered in the Danish Multiple Sclerosis Register were linked with the Danish Cancer Register to obtain information on cancer occurrence. The ratio of the observed to the number of expected cancers based on population-based incidence rates, i.e., the standardised incidence ratio (SIR), served as measure of the relative cancer risk. A database comprising all Danish women born after April 1, 1935, with information on all live-born children, was used in the analyses of breast cancer to adjust for reproductive factors.

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“…EBV is associated with HL in 30–40% of cases [13,14,15], there are examples of familial clustering [16] and case reports of patients with both MS and HL [17,18,19,20] or MS with primary CNS lymphoma [21]. Such associations are disputed by Kurtzke and Hamtoft [22], who cite the disparate regional distribution of the two diseases in Denmark and the bimodal age of onset for HL but not MS. A record linkage study that used the Danish MS and Cancer Registries found no association between MS and HL [23].…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis, Lymphoma and Nasopharyngeal Carcinoma: The Central Role of Epstein-Barr Virus?

Rolls

Giovannoni²,

Constantinescu³

et al. 2009

Eur Neurol

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Background: Multiple sclerosis (MS) and Hodgkin lymphoma (HL) share epidemiologic characteristics suggesting a possible common etiology. Epstein-Barr virus (EBV) is associated with HL, Burkitt lymphoma, some varieties of non-Hodgkin lymphoma (NHL) and nasopharyngeal carcinoma (NPC).Method:Patients were located through MS databases for (a) Barking and Havering, NE London; catchment ∼400,000; MS patient number 751, and (b) Nottingham, catchment ∼2,000,000; MS patient number 1,236. Search was undertaken for lymphoma or NPC and diagnosis of MS verified by McDonald criteria. Results: We identified five UK-born and resident patients of interest: (1) male with onset HL aged 20 years developing relapsing-remitting MS 11 years later; (2) female with severe relapsing-remitting MS whose partner developed NHL, 5 years after MS diagnosis; (3) female with secondary progressive MS beginning at age 38 years who developed NHL 25 years later; (4) female diagnosed with MS aged 19 years who developed HL 4 years later, and (5) female with hereditary motor and sensory neuropathy developing cervical cancer at the age of 32 years, NPC at 33 years, and RR MS at 36 years. Conclusion: Our study supports a possible association between MS, HL, NHL, and perhaps NPC all of which are associated with EBV infection.

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Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis

Abstract: The observed familial clustering of multiple sclerosis and young-adult-onset Hodgkin lymphoma is consistent with the hypothesis that the two conditions share environmental and/or constitutional etiologies.

Cited by 51 publications

References 23 publications

Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries

Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries

Cancer risk among patients with multiple sclerosis: A population‐based register study

Multiple Sclerosis, Lymphoma and Nasopharyngeal Carcinoma: The Central Role of Epstein-Barr Virus?

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