Cancer risk among patients with multiple sclerosis: A population‐based register study

Nielsen, Nete Munk; Rostgaard, Klaus; Rasmussen, Søren; Koch‐Henriksen, Nils; Storm, Hans H.; Melbye, Mads; Hjalgrim, Henrik

doi:10.1002/ijc.21437

Cited by 122 publications

(160 citation statements)

References 46 publications

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“…The number of MS observed corresponds roughly to what is expected for Denmark [14]. We have no explanation for the discrepancy.…”

Section: Page 3 Ofsupporting

confidence: 72%

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Registration of Increased Risk of Brain Cancer after the Diagnosis of Multiple Sclerosis

Nexø¹,

Horváth‐Puhó²,

Sundbøll³

2017

J Mult Scler

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Background: We studied the cancer comorbidity of 18,212 Danish Multiple Sclerosis (MS) patients.Methods: Using data from the Danish National Patient Registry we identified all persons with a first-time MS diagnosis during 1980-2013. Cancer outcomes of the study cohort were ascertained using diagnoses from the Danish Cancer Registry. Patients with cancer prior to MS were excluded. We computed standardized incidence ratios with 95% confidence intervals calculated as the number of observed cancers relative to the expected based on national incidence rates by sex, age and calendar year.Results: All sites of cancers in the CNS were significantly increased, namely cancers of 1) membrane of the brain and spinal meninges, 2) brain, as well as 3) spinal cord, cranial nerves and central nervous system. MS is a disease of the CNS, and the 3 CNS cancer groups were individually significant. Several other cancers were also increased, namely 1) overall cancer, 2) urinary bladder cancer, 3) metastases and non-specified cancer in lymph nodes and 4) basal cell carcinoma. Conclusion:Multiple sclerosis is associated with increased registration of a range of cancers, in particular in the period following debut of MS. The results may be due to detection bias and misregistration. Finally, the results could be due to confounding.

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“…The number of MS observed corresponds roughly to what is expected for Denmark [14]. We have no explanation for the discrepancy.…”

Section: Page 3 Ofsupporting

confidence: 72%

“…A previous Danish report [14] did not find an increased incidence of CNS cancers among MS patients. Because our MS patients were hospitaltreated there could be a tendency that these were the more serious cases.…”

Section: Discussionmentioning

confidence: 56%

Registration of Increased Risk of Brain Cancer after the Diagnosis of Multiple Sclerosis

Nexø¹,

Horváth‐Puhó²,

Sundbøll³

2017

J Mult Scler

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“…Findings from large MS cohorts suggest that the risk of cancer is reduced in MS patients compared with that of the general population [17,18], and cancer-associated mortality has also been found to be lower in MS [19]. Other studies have reported gender-specific risk reductions in women [20] and for men with MS [21]. Lower than expected rates of specific cancers have also been found, including skin malignancies [22] and digestive organ malignancies [23].…”

mentioning

confidence: 99%

Interferons and multiple sclerosis: is it plausible that β-IFN treatment could influence the risk of cancer among MS patients?

Kingwell¹,

Tremlett²

2009

Expert Review of Neurotherapeutics

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“…Tian és mtsai nem mutattak ki meg- növekedett esélyt emlőkarcinóma kialakulására RA-s betegeknél [54]. Mások a sclerosis multiplex és az emlőrák kapcsolatát vizsgálva szintén gyenge korrelációt találtak [55].…”

Section: Az öSztrogénmetabolitok Autoimmun Betegségekre Kifejtett Hatunclassified

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

Kovács

Vásárhelyi

Mészáros³

et al. 2017

Orvosi Hetilap

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Az ösztrogénhormonok fiziológiai szerepe sok tekintetben ismert. Meglehetősen kevés információ áll azonban rendelkezésre az ösztron és az ösztradiol lebontása során képződő vegyületek szerepéről a különböző, ösztrogénhatással összefüggésbe hozott kórképekben. A kutatások intenzív érdeklődésének középpontjában jelenleg a két ösztrogén-hormon mellett tizenhárom extragonadális metabolit áll. A képződő metabolitok protektív vagy éppen proinflammatorikus és/vagy proonkogén hatással rendelkeznek. A szisztémás keringésben mért metabolitszintek nem mutatnak összefüggést a lokálisan megjelenő metabolitokéval, ennek a jövőben diagnosztikai jelentősége lehet. A jelen tanulmány célja a perifériás szövetekben az extragonadális metabolommal kapcsolatos irodalmi források átfogó áttekintése, valamint felhívni a figyelmet a perifériás szövetek ösztrogénhomeosztázisának szerepére, az ösztrogénmetabolom igazolt, valamint a klasszikus hormonhatásoktól eltérő biológiai aktivitására, egyes kórfolyamatokban azonosított klinikai jelentőségére. Ezek az ismeretek a lokálisan determinált kórfolyamatok megértését, korai diagnosztikáját a későbbiekben a metabolomika eszköztárával jelentősen segíthetik. Orv Hetil. 2017; 158(24): 929-937. Kulcsszavak: ösztrogénmetabolom, perifériás szövetek, emlőkarcinóma, HPLC-MS/MS The biological and clinical relevance of estrogen metabolomeConsiderable knowledge has been gathered on the physiological role of estrogens. However, fairly little information is available on the role of compounds produced in the breakdown process of estrone and estradiol wich may play a role in various diseases associated with estrogen impact. To date, approximately 15 extragonadal estrogen-related compounds have been identified. These metabolites may exert protective, or, instead, pro-inflammatory and/or prooncogenic activity in a tissue-specific manner. Systemic and local estrogen metabolite levels are not necesserily correlated, which may promote the diagnostic significance of the locally produced estrogen metabolites in the future. The aim of the present study is a bibliographic review of the extragonadal metabolome in peripheral tissues, and to highlight the role of the peripheral tissue homeostasis of estrogens as well as the non-hormonal biological activity and clinical significance of the estrogen metabolome.

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Cancer risk among patients with multiple sclerosis: A population‐based register study

Cited by 122 publications

References 46 publications

Registration of Increased Risk of Brain Cancer after the Diagnosis of Multiple Sclerosis

Registration of Increased Risk of Brain Cancer after the Diagnosis of Multiple Sclerosis

Interferons and multiple sclerosis: is it plausible that β-IFN treatment could influence the risk of cancer among MS patients?

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

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