Familial ataxia with isolated vitamin E deficiency not due to mutation of à-TTP

Shiojiri, Toshiaki; Yokota, Takanori; Fujimori, N; Mizusawa, Hidehiro

doi:10.1007/s004150050499

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…In contrast to a high affinity to α-tocopherol (100%), α-tocopherol transfer protein (α-TTP) has a much lower affinity towards other vitamin E forms; 50%, 10-30%, and 1% affinity to β-tocopherol, γ-tocopherol, and δ-tocopherol, respectively [78], and plays an important role in the maintenance of high concentrations of α-tocopherol in plasma and some tissues [79,80]. A reduction in plasma γ-tocopherol during enhanced intake of α-tocopherol, such as through supplemental intake, can be explained by the more rapid metabolism of γ-tocopherol occurring when α-tocopherol intake is increased [81].…”

Section: Discussionmentioning

confidence: 99%

Positive Associations of Dietary Intake and Plasma Concentrations of Vitamin E with Skeletal Muscle Mass, Heel Bone Ultrasound Attenuation and Fracture Risk in the EPIC-Norfolk Cohort

2021

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The prevalence of sarcopenia, frailty and fractures is increasing. Prevention options are limited, but dietary factors including vitamin E have the potential to confer some protection. This study investigated cross-sectional associations between dietary and plasma concentrations of vitamin E with indices of skeletal muscle mass (SMM) (n = 14,179 and 4283, respectively) and bone density (n = 14,694 and 4457, respectively) and longitudinal fracture risk (n = 25,223 and 7291, respectively) in European Prospective Investigation Into Cancer and Nutrition (EPIC)-Norfolk participants, aged 39–79 years at baseline. Participants completed a health and lifestyle questionnaire, a 7-day diet diary (7dDD) and had anthropometric measurements taken. Fat-free mass (as a SMM proxy) was measured using bioimpedance and bone density was measured using calcaneal broadband ultrasound attenuation (BUA) and incident fractures over 18.5 years of follow-up. Associations between indices of SMM, BUA and fracture risk were investigated by quintiles of dietary vitamin E intake or plasma concentrations. Positive trends in SMM indices and BUA were apparent across dietary quintiles for both sexes, with interquintile differences of 0.88–1.91% (p < 0.001), and protective trends for total and hip fracture risk. Circulating plasma α- and γ-tocopherol results matched the overall dietary findings. Dietary vitamin E may be important for musculoskeletal health but further investigation is required to fully understand the relationships of plasma tocopherols.

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