Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency

Aslam, Aamir; Misbah, Siraj; Talbot, Kevin; Chapel, H M

doi:10.1016/j.clim.2004.02.001

Cited by 62 publications

(43 citation statements)

References 38 publications

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“…Nutritional deficiencies were reported in three patients with neurologic manifestations, two with vitamin E deficiency, and one with vitamin B12 deficiency [18,19]. The vitamin Edeficient patients presented with tremors, paresthesias, and unsteadiness, and had bland CSF analysis and MRIs with extensive high signal changes in the white matter of the frontal and parietal lobes.…”

Section: Fig 2 Ucsf Metagenomic Deep Sequencing Protocol For Identifmentioning

confidence: 99%

Neurologic Complications of Common Variable Immunodeficiency

et al. 2016

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Common variable immunodeficiency is a rare disorder of immunity associated with a myriad of clinical manifestations including recurrent infections, autoimmunity, and malignancy. Though rare, neurologic complications have been described in a small number of case reports and case series of CVID patients. In this article, we present a patient with CVID who suffered significant neurologic morbidity and categorize the reported range of neurologic complications associated with CVID. Our case highlights the complex nature of neurologic manifestations in CVID patients, and our review of the current database suggests that infection and inflammatory neurologic disorders are the cause of most neurologic presentations.

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Section: Fig 2 Ucsf Metagenomic Deep Sequencing Protocol For Identifmentioning

confidence: 99%

Neurologic Complications of Common Variable Immunodeficiency

et al. 2016

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“…Chronic sepsis of the upper and lower respiratory tracts may lead to chronic otitis media, deafness, bronchiectasis, pulmonary fibrosis and ultimately cor pulmonale. CVIDs may also predispose to gastrointestinal infection and be associated with malabsorption [3]. Approximately 30% of CVID patients have splenomegaly and 12% have arthropathy.…”

Section: Comments From Dr Dilani Arnold Dr Siraj Misbah and Dr Helenmentioning

confidence: 99%

Granulomatous disease: Distinguishing primary antibody disease from sarcoidosis

Arnold

Wiggins

Cunningham‐Rundles

et al. 2008

Clinical Immunology

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“…These preparations are extracted from large pools of donated plasma resulting in a risk of viral transmission including, historically, hepatitis C virus (HCV). Consequently it is standard practice to monitor patients' liver function tests (LFTs) every [8][9][10][11][12] weeks, to detect any signs of hepatitis [3,4]. However, not all patients with LFT rises have evidence of HCV infection [5,6].…”

Section: Introductionmentioning

confidence: 99%

Abnormal liver function in common variable immunodeficiency disorders due to nodular regenerative hyperplasia

Ward¹,

Lucas²,

Piris

et al. 2008

Clinical and Experimental Immunology

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107

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SummaryPatients with common variable immunodeficiency disorders are monitored for liver function test abnormalities. A proportion of patients develop deranged liver function and some also develop hepatomegaly. We investigated the prevalence of abnormalities and types of liver disease, aiming to identify those at risk and determine outcomes. The local primary immunodeficiency database was searched for patients with a common variable immunodeficiency disorder and abnormal liver function and/or a liver biopsy. Patterns of liver dysfunction were determined and biopsies reviewed. A total of 47 of 108 patients had deranged liver function, most commonly raised alkaline phosphatase levels. Twenty-three patients had liver biopsies. Nodular regenerative hyperplasia was found in 13 of 16 with unexplained pathology. These patients were more likely to have other disease-related complications of common variable immunodeficiency disorders, in particular non-coeliac (gluten insensitive) lymphocytic enteropathy. However, five had no symptoms of liver disease and only one died of liver complications. Nodular regenerative hyperplasia is a common complication of common variable immunodeficiency disorders but was rarely complicated by portal hypertension.

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Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency

Cited by 62 publications

References 38 publications

Neurologic Complications of Common Variable Immunodeficiency

Neurologic Complications of Common Variable Immunodeficiency

Granulomatous disease: Distinguishing primary antibody disease from sarcoidosis

Abnormal liver function in common variable immunodeficiency disorders due to nodular regenerative hyperplasia

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