Familial Association of Femoral Trochlear Dysplasia With Recurrent Bilateral Patellar Dislocation

Rebolledo, Brian J.; Nam, Denis; Cross, Michael B.; Green, Daniel W.; Sculco, Thomas P.

doi:10.3928/01477447-20120327-30

Cited by 17 publications

(16 citation statements)

References 15 publications

(13 reference statements)

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“…Trochlear dysplasia may also impair the patellofemoral joint stability and cause patellar instability, patellar dislocation, and finally softening or loss of patellofemoral cartilage. [10] This condition results from chronic friction between the patella and the trochlear groove through which it passes during knee flexion. Although there are few studies in the literature , which have related chondromalacia patella with trochlear dysplasia, the results are conflicting.…”

Section: Discussionmentioning

confidence: 99%

The association of patellar maltracking with infrapatellar fat pad edema and chondromalacia patella: A quantitative morphological magnetic resonance imaging analysis

Gürsoy¹

2018

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the relationship of patellofemoral joint morphology with infrapatellar fat pad edema and chondromalacia patella (CP) using patellar maltracking parameters on magnetic resonance imaging (MRI). Patients and methods: Between January 2010 and January 2013, 50 patients with edema in the superolateral portion of the infrapatellar fat pad (the study group) and control group (n=50) with a normal infrapatellar fat pad were identified on MRI to compare with regard to five patellar maltracking parameters retrospectively. These parameters were trochlear depth, the trochlear sulcus angle (TSA), patellar translation, the lateral patellofemoral angle (PFA), and the Insall-Salvati ratio. The relationship between patellar maltracking and the CP was also evaluated using the same parameters. Results: In the study group, the Insall-Salvati index and TSA were significantly higher (p=0.001), and the trochlear depth and PFA were low (p=0.001, p=0.01), while patellar translation showed no difference (p=0.957). In the CP group, the Insall-Salvati index and TSA were significantly high (p=0.001), the trochlear depth was low (p=0.001). No statistically significant difference was found in PFA and patellar translation (p=0.292, p=0.446). Conclusion: Our study results suggest that edema in the superolateral portion of infrapatellar fat pad and CP are associated with patellar maltracking.

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Section: Discussionmentioning

confidence: 99%

The association of patellar maltracking with infrapatellar fat pad edema and chondromalacia patella: A quantitative morphological magnetic resonance imaging analysis

Gürsoy¹

2018

Turk J Phys Med Rehab

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“…abnormalities, including subtalar coalition (15), slipped capital femoral epiphysis (16), and trochlear dysplasia, (17) and, therefore, elucidation of a primary morphologic abnormality of the currently asymptomatic contralateral patellofemoral joints may provide insight into the underlying predisposing factors for PI. Additionally, these underlying anatomic and functional abnormalities may predispose the contralateral asymptomatic joints to future anterior knee pain, instability, and OA.…”

Section: Discussionmentioning

confidence: 99%

Imaging Characteristics of Contralateral Asymptomatic Patellofemoral Joints in Patients with Unilateral Instability

Demehri¹,

Thawait²,

Williams³

et al. 2014

Radiology

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).q RSNA, 2014 Purpose:To test the hypothesis that in patients with unilateral patellofemoral instability (PI), the contralateral asymptomatic joints have abnormal morphology and imaging features of osteoarthritis (OA) at four-dimensional (4D) computed tomography (CT). Materials and Methods:The institutional review board approved this HIPAA-compliant retrospective study. Informed consent was waived. Radiology records were reviewed to identify 25 patients (male-female ratio, 0.56; median age, 20 years; range, 13-43 years) with unilateral PI undergoing 4D CT and 25 age-and sex-matched control patients undergoing multidetector CT. Trochlear groove depth (TGD), tibial tuberosity-trochlear groove (TT-TG) distance, and patellar height ratio (PHR) were determined to compare morphology, and bisect offset (BO) measurements were obtained to compare lateral displacement of the patella between the two groups by using the Wilcoxon rank-sum test. All images were interpreted by trained observers. Tracking patterns of the patellae were determined by obtaining BO measurements at various flexion angles with 4D CT. Results:In the contralateral asymptomatic joints, TGD (median, 3.0 mm; 95% confidence interval [CI]: 2.5, 4.6; P , .0001), TT-TG (median, 15 mm; 95% CI: 12.7, 18; P = .008), PHR (median, 1.17; 95% CI: 1.09, 1.2; P = .002), and patellar lateral displacement (BO, 85%; 95% CI: 76.2%, 98.2%; P , .0001) were different from measurements obtained in the control group: TGD median, 5.0 mm (95% CI: 2.2, 7.6); TT-TG median, 10.9 mm (95% CI: 3.4, 20.7); PHR median, 0.92 (95% CI: 0.67, 1.36); and BO median, 63% (95% CI: 59%, 68.4%). OA was detected in 40% of asymmetrical contralateral joints (10 of 25). By using 4D CT data, multiple regression analysis demonstrated that TGD (P = .026) and BO measurements obtained at 30° of knee flexion (P = .047) had an association with the presence of OA. Conclusion:Abnormal morphology and imaging features of OA are relatively common in contralateral asymptomatic joints of young patients with unilateral PI.q RSNA, 2014

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“…Familial patellar dislocation is uncommon but has been reported in the literature. [2][3][4][5] Previous case series have suggested a genetic cause of but the exact genetic and molecular basis has not been well studied.…”

Section: Discussionmentioning

confidence: 99%

“…3 Similarly, Rebolledo reported three patients in one family (mother and two children) with trochlear dysplasia and recurrent bilateral patellar dislocations in 2012 following a French report on familiar trochlear dysplasia by Rouvillain. 4,5 These case reports of familial disease pattern suggest a genetic component, although the underlying genetic basis is yet to be identified.…”

Section: Introductionmentioning

confidence: 99%

Familial patellar dislocation associated with t(15;20) (q24;q13.1)

Chan

Chau

Woo

et al. 2018

J Orthop Surg (Hong Kong)

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Patellar instability is a common debilitating injury affecting young active individuals. It accounts for approximately 3% of all knee injuries. We report a family, of which five members across three generations, who suffered from autosomal dominant familial recurrent patellar dislocation as well as short stature. All of them have recurrent patellar dislocations before the age of 15. The affected patients in all three generations have been genetically screened. Genotypical evaluation revealed a balanced translocation of chromosomes 15 and 20.

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Familial Association of Femoral Trochlear Dysplasia With Recurrent Bilateral Patellar Dislocation

Cited by 17 publications

References 15 publications

The association of patellar maltracking with infrapatellar fat pad edema and chondromalacia patella: A quantitative morphological magnetic resonance imaging analysis

The association of patellar maltracking with infrapatellar fat pad edema and chondromalacia patella: A quantitative morphological magnetic resonance imaging analysis

Imaging Characteristics of Contralateral Asymptomatic Patellofemoral Joints in Patients with Unilateral Instability

Familial patellar dislocation associated with t(15;20) (q24;q13.1)

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