Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden

Li, Xinjun; Sjöstedt, Cecilia; Sundquist, Jan; Zöller, Bengt; Sundquist, Kristina

doi:10.1097/ypg.0000000000000212

Cited by 19 publications

(17 citation statements)

References 27 publications

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“…For example, a recent meta-analysis of 49 studies including approximately 210,000 ADHD cases and three million controls reported an association between ADHD and asthma (pooled odds ratio [OR] = 1.53; 95% confidence interval [CI] = [1.41, 1.65]; Cortese et al, 2018). It is also known that children with ADHD have a higher risk of comorbid diseases of the eye (DeCarlo, Swanson, McGwin, Visscher, & Owsley, 2016; Redondo et al, 2018), autoimmune and metabolic diseases (Chen, Lee, Yeh, & Lin, 2013; Li, Sjostedt, Sundquist, Zoller, & Sundquist, 2018; Nielsen, Benros, & Dalsgaard, 2017), and immunological diseases (Muskens, Velders, & Staal, 2017). Less is known about associations of ADHD with other nonpsychiatric diseases.…”

Section: Introductionmentioning

confidence: 99%

Psychiatric and Nonpsychiatric Comorbidities Among Children With ADHD: An Exploratory Analysis of Nationwide Claims Data in Germany

Akmatov¹,

Ermakova²,

Bätzing³

2019

J Atten Disord

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Objective: This study examined the full spectrum of comorbid disorders in all statutory-health-insured children aged 5 to 14 years with ADHD in 2017 by using nationwide claims data in Germany. Method: Children with ADHD ( n = 258,662) were compared for the presence of 864 comorbid diseases with a control group matched by gender, age, and region of residence ( n = 2,327,958). Results: Among others, metabolic disorders (odds ratio [OR] = 9.18; 95% confidence interval [CI] = [8.43, 9.99]), viral pneumonia (OR = 4.95; 95% CI = [2.37, 10.33]), disorders of white blood cells (OR = 4.55; 95% CI = [3.83, 5.40]), kidney failure (OR = 3.33; 95% CI = [2.65, 4.18]), hypertension (OR = 3.26; 95% CI = [3.00, 3.55]), obesity (OR = 2.85; 95% CI = [2.80, 2.91]), type 2 diabetes (OR = 2.61; 95% CI = [2.11, 3.23]), migraine (OR = 2.49; 95% CI = [2.37, 2.61]), asthma (OR = 2.19; 95% CI = [2.16, 2.22]), atopic dermatitis (OR = 2.10; 95% CI = [2.16, 2.23]), juvenile arthritis (OR = 1.56; 95% CI = [1.39, 1.76]), glaucoma (OR = 1.51; 95% CI = [1.30, 1.75]), and type 1 diabetes (OR = 1.30; 95% CI = [1.20, 1.40]) were more likely to be diagnosed in ADHD children. Conclusion: Along with psychiatric diseases, various somatic diseases were more common in ADHD children. The results have direct implications for patient care, including fine-grained diagnostics and personalized therapy.

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Section: Introductionmentioning

confidence: 99%

Psychiatric and Nonpsychiatric Comorbidities Among Children With ADHD: An Exploratory Analysis of Nationwide Claims Data in Germany

Akmatov¹,

Ermakova²,

Bätzing³

2019

J Atten Disord

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“…Similarly, dental caries or dental-related issues were also more prevalent in JSS patients (p = 0.01). Interestingly, about 11% of our cohort patients reported attention-deficit/hyperactive disorder (ADHD) or autism spectrum disorders, suggesting a potential link between maternal autoimmune diseases/inflammation and those conditions (19,20).…”

Section: Jss Patients Exhibit History Of Sicca Symptoms and Glandular Changes Noted By Sgusmentioning

confidence: 97%

The Diagnostic Performance of Early Sjögren’s Syndrome Autoantibodies in Juvenile Sjögren’s Syndrome: The University of Florida Pediatric Cohort Study

et al. 2021

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ObjectivesThe aim of this study was to evaluate the clinical validity of early Sjögren’s syndrome (SS) autoantibodies (eSjA), which were originally marketed for early diagnosis of SS, for juvenile SS (JSS) in a recently identified pediatric cohort.MethodsA total of 105 symptomatic subjects with eSjA results available were evaluated at the Center for Orphaned Autoimmune Disorders at the University of Florida and enrolled for this study. JSS diagnosis was based on the 2016 ACR/EULAR SS criteria. Demographic/clinical/laboratory parameters were compared between JSS (n = 27) and non-JSS (n = 78) for % positivity, sensitivity, and specificity of eSjA (SP1, anti-salivary protein; CA6, anti-carbonic anhydrase VI; PSP, anti-parotid secretory protein) and classic SS-autoantibodies (cSjA; ANA, SSA/SSB, RF, and others) either alone or in combination. Associations between eSjA and diagnostic/glandular parameters were also determined by Fisher’s exact test.ResultsCompared to non-JSS, JSS patients exhibited sicca symptoms demonstrating reduced unstimulated salivary flow rate (USFR) and abnormal glandular features revealed by salivary gland ultrasound (SGUS). Among cSjA, ANA demonstrated the highest sensitivity of 69.2%, while SSA, SSB, and RF showed around 95% specificities for JSS diagnosis. The % positive-SSA was notably higher in JSS than non-JSS (56% vs. 5%). Of eSjA, anti-CA6 IgG was the most prevalent without differentiating JSS (37%) from non-JSS (32%). Sensitivity and specificity of eSjA were 55.6 and 26.9%, respectively. Autoantibodies with potentially applicable specificity/sensitivity for JSS were seen only in cSjA without a single eSjA included. There were no associations detected between eSjA and focus score (FS), USFR, SSA, SGUS, and parotitis/glandular swelling analyzed in the entire cohort, JSS, and non-JSS. However, a negative association between anti-PSP and parotitis/glandular swelling was found in a small group of positive-SSA (n = 19, p = 0.02) whereas no such association was found between anti-PSP-positive compared to anti-PSP-negative. JSS and non-JSS groups differed in FS, USFR, and EULAR SS Patient Reported Index Dryness/Mean in CA6/PSP/ANA, SP1, and SSA-positive groups, respectively. Additionally, a higher FS was found in RF-positive than RF-negative individuals.ConclusionseSjA underperformed cSjS in differentiating JSS from non-JSS. The discovery of clinical impact of eSjA on early diagnosis of JSS necessitates a longitudinal study.

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“…The inflammatory products discharged from the initial step would be focused in the second step. 6,13 In the…”

Section: Re Vie Wmentioning

confidence: 99%

“…A first nonspecific inflammatory step adds to the creation of numerous substances, including cytokines, stress proteins, adhesion molecules, or autoantigens translocated from intracellular areas. The inflammatory products discharged from the initial step would be focused in the second step . In the second step, there might be disease explicit responses, including T cells, B cells, autoantibodies, and immune deposits under the limitation of hereditary backgrounds …”

Section: Reviewmentioning

confidence: 99%

A secondary discoid lupus erythematosus induced by scald of edible oil: An illustration of Koebner phenomenon

Mei

Wei

et al. 2019

J of Cosmetic Dermatology

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Background Discoid lupus erythematosus (DLE) is a most well‐known clinical variation of chronic cutaneous lupus erythematosus inside the spectrum of lupus erythematosus (LE). Cutaneous trauma remains a significant and peculiar causative factor for DLE. Aims We present a case wherein the patient demonstrated unilateral distribution of DLE on a clinically normal appearing occult facial scald of edible oil, representing Koebner phenomenon (KP) i.e. occurrence of a new skin disease at the site of an unrelated and already healed one. Patient/Methods The 53 years old female patient was unique because she experienced DLE on the nasal back. Results The injury was totally settled following a month treatment of oral hydroxychloroquine and topical 0.03% tacrolimus ointment. After three months, she encountered an accidental edible oil scald on the right upper cheek. Several small vesicles appeared on a soybean‐sized erythema base with a burning sensation. Conclusion We review the literature and conclude by discussing important histologic highlights to think about while endeavoring to perceive the fundamental character and pathogenicity of such sores.

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Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden

Cited by 19 publications

References 27 publications

Psychiatric and Nonpsychiatric Comorbidities Among Children With ADHD: An Exploratory Analysis of Nationwide Claims Data in Germany

Psychiatric and Nonpsychiatric Comorbidities Among Children With ADHD: An Exploratory Analysis of Nationwide Claims Data in Germany

The Diagnostic Performance of Early Sjögren’s Syndrome Autoantibodies in Juvenile Sjögren’s Syndrome: The University of Florida Pediatric Cohort Study

A secondary discoid lupus erythematosus induced by scald of edible oil: An illustration of Koebner phenomenon

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