Familial aspects of decreased hypoxic drive in endurance athletes

Scoggin, Charles H.; Doekel, R. D.; Kryger, M H; Zwillich, Clifford W.; Weil, J. V.

doi:10.1152/jappl.1978.44.3.464

Cited by 80 publications

(46 citation statements)

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“…In studies of' patieints with unexplained respiratory f;ailure in wlhom ventilatory responses to hypoxia were found to be decreased, similarly decreased responses were found in healthy f;amily members (4,5). Furthermore, Saunders et al have shown a correlation between hypereapnic ventilatory responses seeni in championship swimmers and their siblings (9), and we have found decreased hypoxic ventilatory responses in successf'tul endurance runners and in their nonathletic parents and siblings (10).…”

Section: Introductionsupporting

confidence: 73%

Hereditary aspects of decreased hypoxic response.

Collins¹,

Scoggin²,

Zwillich³

et al. 1978

J. Clin. Invest.

119

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A B S T R A C T Decreased ventilatory responses to hypoxia and hypereapnia have been demonstrated in a variety of disorders; however, the etiology of'these decreased drives remains virtually unknown. Recent observations have suggested a f'amilial influence on hypoxic and hypereapnic ventilatory response, but it is unclear whether this influence is the result of' hereditary or environmental influences. Therefore we measured the ventilatory response to isocapnic hypoxia (HVR) and hyperoxic hypercapnia in 12 pairs of identical and 12 pairs of nonidentical twinis. Significant correlation (P < 0.01) was found for HVR within identical twin pairs but not within nonidentical twin pairs. Identical twins resembled each other more closely with respect to HVR than was the case for nonidentical twins (P < 0.0125). This was independent of body size, blood Pco2, or pH. No such correlation could be found for ventilatory response to hyperoxic hypercapnia. It is concluded that hereditary influences affect HVR and it is speculated that such influences may play a role in clinical conditions characterized by decreased hypoxic ventilatory responses.

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Section: Introductionsupporting

confidence: 73%

Hereditary aspects of decreased hypoxic response.

Collins¹,

Scoggin²,

Zwillich³

et al. 1978

J. Clin. Invest.

119

View full text Add to dashboard Cite

show abstract

“…Reasons behind the varied performance response to LHTL training are probably multi-factorial however genetics may play a large part [38]. Studies have shown that a transcriptional factor, called a hypoxia-inducible factor (HIF), is essential in promoting cellular adaptation to changes in oxygen availability and regulating the hypoxic gene expression [39].…”

Section: Subjective Variablesmentioning

confidence: 99%

Live High-Train Low Altitude Training: Responders and Non- Responders

Hamlin¹,

Manimmanakorn²,

Creasy³

et al. 2015

J Athl Enhancement

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Objective: Investigate differences between athletes that responded (improved performance) compared to those that did not, after a 20-day "live high-train low" (LHTL) altitude training camp. Methods:Ten elite triathletes completed 20 days of live high (1545-1650 m), train low (300 m) training. The athletes underwent (i), two 800-m swimming time trials at sea-level (1 week prior to and 1 week after the altitude camp) and (ii) two 10-min standardised submaximal cycling tests at altitude on day 1 and day 20 of the altitude camp. Acute mountain sickness (AMS) was also measured during the camp. Based on their 800-m swimming time trial performances, athletes were divided into responders (improved by 3.2 ± 2.2%, mean ± SD, n=6) and non-responders (decreased by 1.8 ± 1.2%, n=4).Results: Compared to non-responders, the responders had lower exercise heart rates (-6.3 ± 7.8%, mean ± 90% CL, and higher oxygen saturations (1.2 ± 1.3%) at the end of the 10-min submaximal test after the camp. Compared to the responders, the non-responders had substantially higher VE and VE/VO 2 during the submaximal test on day 1 of the altitude training camp, and a substantially higher RER during the submaximal test on day 20 of the camp. As a result of the altitude training, exercise economy of the non-responders compared to the responders deteriorated (i.e., non-responders required more oxygen per watt). Non-responders were 3.0 times (90% CL=0.5-16.6) more likely to suffer symptoms of acute mountain sickness during first 5 days of altitude compared to responders. Conclusion:Changes in SpO 2 , heart rate and some respiratory variables during exercise and resting AMS scores may help determine athletes that respond to LHTL altitude training camps from athletes that fail to respond to such training.

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“…Med Scoggin et al 1978), but it is not yet certain whether hypercapnic ventilatory response is changed by physical trainig. In fact, the ventilatory response to hypercapnia after training has been reported to be decreased (Blum et al 1979), unchanged (Bradley et al 1980;Hughson 1980) and increased (Kelley et al 1984) as compared with pretraining.…”

Section: Expmentioning

confidence: 99%