1978
DOI: 10.1172/jci109093
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Hereditary aspects of decreased hypoxic response.

Abstract: A B S T R A C T Decreased ventilatory responses to hypoxia and hypereapnia have been demonstrated in a variety of disorders; however, the etiology of'these decreased drives remains virtually unknown. Recent observations have suggested a f'amilial influence on hypoxic and hypereapnic ventilatory response, but it is unclear whether this influence is the result of' hereditary or environmental influences. Therefore we measured the ventilatory response to isocapnic hypoxia (HVR) and hyperoxic hypercapnia in 12 pair… Show more

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Cited by 119 publications
(44 citation statements)
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“…On the other hand, the HVR was positively correlated with the breathlessness during moderate desaturation, while there was no such correlation between the HCVR and the breathlessness related to PET,CO 2 .…”
Section: Discussionmentioning
confidence: 74%
See 3 more Smart Citations
“…On the other hand, the HVR was positively correlated with the breathlessness during moderate desaturation, while there was no such correlation between the HCVR and the breathlessness related to PET,CO 2 .…”
Section: Discussionmentioning
confidence: 74%
“…This relationship was weak when evaluated using the slope of the breathlessness-V 'E/MVV line (p=0.082). Figure 3 demonstrates the relationship between ventilatory response and breathlessness related to PET,CO 2 or Sa,O 2 . There was no correlation between the HCVR and the breathlessness response related to PET,CO 2 .…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…The correlation coefficients between S/BW or S/BSA and age were both -0.49 (p < 0.01). Using almost identical methods to those used in the present study, COLLINS et al (1978) studied hypercapnic and hypoxic chemosensitivities in 24 pairs of twins. Twenty pairs of their subjects were 10-18 yrs old.…”
Section: Discussionmentioning
confidence: 99%