Hereditary aspects of decreased hypoxic response.

Collins, David; Scoggin, Charles H.; Zwillich, Clifford W.; Weil, John V.

doi:10.1172/jci109093

Cited by 119 publications

(44 citation statements)

References 21 publications

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“…On the other hand, the HVR was positively correlated with the breathlessness during moderate desaturation, while there was no such correlation between the HCVR and the breathlessness related to PET,CO 2 .…”

Section: Discussionmentioning

confidence: 74%

“…This relationship was weak when evaluated using the slope of the breathlessness-V 'E/MVV line (p=0.082). Figure 3 demonstrates the relationship between ventilatory response and breathlessness related to PET,CO 2 or Sa,O 2 . There was no correlation between the HCVR and the breathlessness response related to PET,CO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Minute ventilation (V 'E) was calculated every 15 s by integrating the airflow. Expiratory gas was continuously monitored by a mass spectrometer (Medical Gas Analyzer MGA-1100; Perkin-Elmer, Pomona, CA, USA) and partial pressures of CO 2 and O 2 in end-tidal samples (PET,CO 2 and PET,O 2 , respectively) were used to represent the levels of chemical drives. Arterial oxygen saturation (Sa,O 2 ) was monitored by a finger-tip pulse oximeter (Biox 3740; Ohmeda, Liberty Cornercity, NJ, USA).…”

Section: Measurements Of Ventilatory Responsementioning

confidence: 99%

“…The responses are essentially endogenous in origin [1][2][3] and broadly distributed even among normal subjects. Although they are highly reproducible within subjects [4,5], several lines of evidence suggest that a cortical process may influence the ventilatory responses when examined in a conscious state.…”

mentioning

confidence: 99%

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Relationship between breathlessness and hypoxic and hypercapnic ventilatory response in patients with COPD

Kobayashi¹,

Nishimura²,

Yamomoto³

et al. 1996

Eur Respir J

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R Re el la at ti io on ns sh hi ip p b be et tw we ee en n b br re ea at th hl le es ss sn ne es ss s a an nd d h hy yp po ox xi ic c a an nd d h hy yp pe er rc ca ap p--SThe mean value of the breathlessness at two different levels of ventilation was greater during HVR than during HCVR, suggesting that hypoxia is dyspnogenic independently of ventilatory stimulation. The HCVR was inversely correlated with the breathlessness response to ventilation, while similar correlation was partly present for HVR. The HVR was positively correlated with the breathlessness at an Sa,O 2 of 80%, whilst there was no such correlation between the HCVR and the breathlessness related to PET,CO 2 . Therefore, patients with a higher breathlessness related to increased ventilation had a lower HCVR and HVR, whilst those with a higher breathlessness with desaturation, which might include a direct influence of hypoxia, had a higher HVR.These findings suggest an interaction between ventilatory response and breathlessness during the test, which may partly include behavioural modulation of HCVR and HVR through the breathlessness in various ways, depending on the origin and nature of the sensation. Eur Respir J., 1996Respir J., , 9, 2340Respir J., -2345

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Section: Discussionmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Measurements Of Ventilatory Responsementioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Relationship between breathlessness and hypoxic and hypercapnic ventilatory response in patients with COPD

Kobayashi¹,

Nishimura²,

Yamomoto³

et al. 1996

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…The correlation coefficients between S/BW or S/BSA and age were both -0.49 (p < 0.01). Using almost identical methods to those used in the present study, COLLINS et al (1978) studied hypercapnic and hypoxic chemosensitivities in 24 pairs of twins. Twenty pairs of their subjects were 10-18 yrs old.…”

Section: Discussionmentioning

confidence: 99%

Hypercapnic and hypoxic ventilatory responses during growth.

et al. 1986

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Cross-sectional studies on hypercapnic and hypoxic ventilatory chemosensitivities were performed in 71 children ranging in age from 7 to 18 yrs. The subjects were classified into 6 successive 2-year age groups. CO2 ventilatory response was measured by rebreathing 5 % CO2 in Oz, a slight modification of the method originally proposed by Read. The results were evaluated when the C02-ventilation feedback control system was supposed to have attained the open-loop condition. Hypoxic ventilatory response was measured by the isocapnic progressive hypoxia test. To obtain good reproducibility in the ventilatory response, end-tidal P~oz was maintained at 5 mmHg higher than the resting condition throughout the test. Normalized ventilatory responses to CO2 by body surface area (S/BSA) progressively decreased from the 7-8 through the 11-12 yr groups, and then tended to decrease further in a more gradual manner with increasing age. This trend was very similar to the normalized CO2 output (V"oz/BSA), but did not parallel so closely the normalized Oz intake (Voz/BSA). When ventilatory and metabolic parameters were normalized by body weight (BW), or the lean body mass (LBM), qualitatively similar relationships between CO2 sensitivities and metabolic parameters were also obtained. Contrary to the hypercapnic response, hypoxic ventilatory chemosensitivities were not significantly different among the 6 different age groups. We concluded that normalized hypercapnic chemosensitivity decreased during growth and corresponded well with decreased CO2 output per unit body mass.Key words : hypercapnic ventialtory response, hypoxic ventilatory response, body weight, body surface area, lean body mass.

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Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives

Beall

Strohl

Blangero

et al. 1997

Am. J. Phys. Anthropol.

196

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Newcomers acclimatizing to high altitude and adult male Tibetan high altitude natives have increased ventilation relative to sea level natives at sea level. However, Andean and Rocky Mountain high altitude natives have an intermediate level of ventilation lower than that of newcomers and Tibetan high altitude natives although generally higher than that of sea level natives at sea level. Because the reason for the relative hypoventilation of some high altitude native populations was unknown, a study was designed to describe ventilation from adolescence through old age in samples of Tibetan and Andean high altitude natives and to estimate the relative genetic and environmental influences. This paper compares resting ventilation and hypoxic ventilatory response (HVR) of 320 Tibetans 9-82 years of age and 542 Bolivian Aymara 13-94 years of age, native residents at 3,800-4,065 m. Tibetan resting ventilation was roughly 1.5 times higher and Tibetan HVR was roughly double that of Aymara. Greater duration of hypoxia (older age) was not an important source of variation in resting ventilation or HVR in either sample. That is, contrary to previous studies, neither sample acquired hypoventilation in the age ranges under study. Within populations, greater severity of hypoxia (lower percent of oxygen saturation of arterial hemoglobin) was associated with slightly higher resting ventilation among Tibetans and lower resting ventilation and HVR among Aymara women, although the associations accounted for just 2-7% of the variation. Between populations, the Tibetan sample was more hypoxic and had higher resting ventilation and HVR. Other systematic environmental contrasts did not appear to elevate Tibetan or depress Aymara ventilation. There was more intrapopulation genetic variation in these traits in the Tibetan than the Aymara sample. Thirty-five percent of the Tibetan, but none of the Aymara, resting ventilation variance was due to genetic differences among individuals. Thirty-one percent of the Tibetan HVR, but just 21% of the Aymara, HVR variance was due to genetic differences among individuals. Thus there is greater potential for evolutionary change in these traits in the Tibetans. Presently, there are two different ventilation phenotypes among high altitude natives as compared with sea level populations at sea level: lifelong sustained high resting ventilation and a moderate HVR among Tibetans in contrast with a slightly elevated resting ventilation and a low HVR among Aymara.

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Hereditary aspects of decreased hypoxic response.

Cited by 119 publications

References 21 publications

Relationship between breathlessness and hypoxic and hypercapnic ventilatory response in patients with COPD

Relationship between breathlessness and hypoxic and hypercapnic ventilatory response in patients with COPD

Hypercapnic and hypoxic ventilatory responses during growth.

Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives

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