Familial aggregation of resting blood pressure and heart rate in a sedentary population The heritage family study

An, Peng

doi:10.1016/s0895-7061(98)00261-1

Cited by 55 publications

(41 citation statements)

References 19 publications

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“…In previous population studies, sibsib blood pressure correlations have been in the range of 0.14 to 0.18. 3 Similarly, in this black group of hypertensive individuals, sib-sib correlations for systolic and diastolic blood pressures, off of antihypertensive drug therapy, were generally within this range, even when these measurements were obtained at an inpatient clinical research center under standardized conditions. Compared with measurements at 1 point in time, higher heritability estimates were generally observed when multiple blood pressure measurements obtained over 24 hours were averaged.…”

Section: Kotchen Et Al Candidate Hypertension-related Phenotypesmentioning

confidence: 67%

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Genetic Determinants of Hypertension

Kotchen

Grim

et al. 2000

Hypertension

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Abstract-Our long-term objective is to identify genes whose expression results in hypertension and in phenotypic changes that may contribute to hypertension. The purpose of the present study was to describe evidence for the heritability of hypertension-related phenotypes in hypertensive, hyperlipidemic black sib pairs. Outpatient anthropomorphic measurements were obtained in Ͼ200 affected sib pairs. In addition, 68 of these sib pairs were studied under controlled, standardized conditions at an inpatient clinical research center while off both antihypertensive and lipid-lowering medications. Heritability was estimated on the basis of sib-sib correlations and with an association model. Higher heritability estimates for blood pressure were observed with multiple measurements averaged over 24 hours than with measurements at a single time point, and heritability estimates for nighttime blood pressures were higher than those for daytime blood pressures. Heritability estimates for several of the phenotypes were augmented by obtaining measurements in response to a standardized stimulus, including (1) blood pressure responses to the assumption of upright posture, standardized psychological stress, and norepinephrine infusion; (2) plasma renin, aldosterone, epinephrine, and cAMP and cGMP responses to the assumption of upright posture; (3) para-aminohippurate and inulin clearances in response to norepinephrine infusion; and (4) plasma arginine vasopressin in response to NaCl infusion. High heritability estimates were also observed for various measures of body size and body fat, left ventricular size, cardiac index, stroke volume, total peripheral resistance, and serum concentrations of LDL and HDL cholesterol and leptin. These heritability estimates identify the hypertension-related phenotypes that may facilitate the identification of specific genetic determinants of hypertension in blacks with hyperlipidemia. (Hypertension. 2000;36:7-13.)Key Words: blacks Ⅲ cholesterol Ⅲ genetics Ⅲ phenotype A doption, twin, and family studies document a significant heritable component to blood pressure levels and hypertension. [1][2][3] Estimates of the heritability of resting systolic and diastolic blood pressures, based on family studies, are generally in the range of 15% to 35%. In twin studies, heritability estimates of blood pressure are Ϸ60% for males and Ϸ30% to 40% for females. 2 A heritable component to salt sensitivity of blood pressure has been described in blacks. 4 A large proportion of the phenotypic variation in blood pressure appears to be inherited as a polygenic trait. 5,6 Our long-term objective is to identify genetic loci and specific genes whose expression results in hypertension and in phenotypic changes that may contribute to hypertension.Blacks are one focus of our studies. In the United States, the prevalence of hypertension is 50% greater in blacks than in whites. 7 In blacks, hypertension appears earlier, is generally more severe, and results in high rates of morbidity and mortality from stroke, heart failure, ...

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Section: Kotchen Et Al Candidate Hypertension-related Phenotypesmentioning

confidence: 67%

“…[1][2][3] Estimates of the heritability of resting systolic and diastolic blood pressures, based on family studies, are generally in the range of 15% to 35%. In twin studies, heritability estimates of blood pressure are Ϸ60% for males and Ϸ30% to 40% for females.…”

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confidence: 99%

Genetic Determinants of Hypertension

Kotchen

Grim

et al. 2000

Hypertension

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“…Blood pressure. A random-zero sphygmomanometer was used to determine resting blood pressure using the Heritage protocol (17). Readings were taken in the morning before 11:00 A.M. in a room with temperatures between 21 and 25°C.…”

Section: Interventionmentioning

confidence: 99%

Biologic and Quality-of-Life Outcomes From the Mediterranean Lifestyle Program

et al. 2003

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OBJECTIVE -Few multiple lifestyle behavior change programs have been designed to reduce the risk of coronary heart disease in postmenopausal women with type 2 diabetes. This study tested the effectiveness of the Mediterranean Lifestyle Program (MLP), a comprehensive lifestyle self-management program (Mediterranean low-saturated fat diet, stress management training, exercise, group support, and smoking cessation), in reducing cardiovascular risk factors in postmenopausal women with type 2 diabetes.RESEARCH DESIGN AND METHODS -Postmenopausal women with type 2 diabetes (n ϭ 279) were randomized to either usual care (control) or treatment (MLP) conditions. MLP participants took part in an initial 3-day retreat, followed by 6 months of weekly meetings, to learn and practice program components. Biological end points were changes in HbA 1c , lipid profiles, BMI, blood pressure, plasma fatty acids, and flexibility. Impact on quality of life was assessed.RESULTS -Multivariate ANCOVAs revealed significantly greater improvements in the MLP condition compared with the usual care group on HbA 1c , BMI, plasma fatty acids, and quality of life at the 6-month follow-up. Patterns favoring intervention were seen in lipids, blood pressure, and flexibility but did not reach statistical significance.CONCLUSIONS -These results demonstrate that postmenopausal women with type 2 diabetes can make comprehensive lifestyle changes that may lead to clinically significant improvements in glycemic control, some coronary heart disease risk factors, and quality of life.

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“…These factors may act in an additive or multiplicative manner. Epidemiological studies have demonstrated that hypertension segregates within families 7 and its prevalence differs between ethnicities. 8 Common variants in a number of genes are thought to explain some of this difference.…”

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confidence: 99%

Association Between Physical Activity and Blood Pressure Is Modified by Variants in the G-Protein Coupled Receptor 10

et al. 2004

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Abstract-Hypertension is strongly related to cardiovascular disease and all-cause mortality. Exercise reduces blood pressure but the response varies between individuals. The mechanisms by which physical activity energy expenditure (PAEE) modifies blood pressure are not fully defined but include modulation of sympathetic tone. Novel polymorphisms in the G-protein coupled receptor (GPR10) have been linked with high blood pressure. GPR10 may mediate the relationship between PAEE and blood pressure via central nervous mechanisms. We examined whether two GPR10 polymorphisms (G-62A and C914T) modify the association between PAEE and blood pressure in the MRC Ely study (Nϭ687

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Familial aggregation of resting blood pressure and heart rate in a sedentary population The heritage family study

Cited by 55 publications

References 19 publications

Genetic Determinants of Hypertension

Genetic Determinants of Hypertension

Biologic and Quality-of-Life Outcomes From the Mediterranean Lifestyle Program

Association Between Physical Activity and Blood Pressure Is Modified by Variants in the G-Protein Coupled Receptor 10

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