Association Between Physical Activity and Blood Pressure Is Modified by Variants in the G-Protein Coupled Receptor 10

Franks, Paul W.; Bhattacharyya, Sumit; Luan, Jian’an; Montague, Carl; Brennand, John; Challis, Benjamin; Brage, Sören; Ekelund, Ulf; Middelberg, Rita P. S.; O’Rahilly, Stephen; Wareham, Nicholas J.

doi:10.1161/01.hyp.0000109319.63240.08

Cited by 25 publications

(15 citation statements)

References 20 publications

(26 reference statements)

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“…1 However, it is probable that BP, like other complex traits, is a function of interactions between genetic and environmental factors. 26 This may explain why no evidence of association between 11␤HSD1 genetic variability and hypertension has yet been reported in humans, despite evidence to this effect in animals. 15,16 Thus, the successful detection of such genetic effects could depend greatly on the background level of these environment exposures during early development (chronic effects) and at the time of the examination (acute effects).…”

Section: Discussionmentioning

confidence: 99%

Interaction Between an 11βHSD1 Gene Variant and Birth Era Modifies the Risk of Hypertension in Pima Indians

Franks

Knowler²,

Nair³

et al. 2004

Hypertension

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Section: Discussionmentioning

confidence: 99%

Interaction Between an 11βHSD1 Gene Variant and Birth Era Modifies the Risk of Hypertension in Pima Indians

Franks

Knowler²,

Nair³

et al. 2004

Hypertension

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“…Figure 5 shows the interaction between the G62A variant at the G-protein-coupled receptor 10 (GPR10) gene and the physical activity on blood pressure in 700 middle-aged UK whites; 56 these data indicate that the association between physical activity and blood pressure is dependent on the genotype carried at the G62A locus. In common 'G' allele homozygotes in this study, a strong inverse relationship was observed between physical activity and blood pressure.…”

Section: Gene-drug Interactionsmentioning

confidence: 99%

Identifying genes for primary hypertension: methodological limitations and gene–environment interactions

Franks

2008

J Hum Hypertens

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Hypertension segregates within families, indicating that genetic factors explain some of the variance in the risk of developing the disease; however, even with major advances in genotyping technologies facilitating the discovery of multiple genetic risk markers for cardiovascular and metabolic diseases, little progress has been made in defining the genetic defects that cause elevations in blood pressure. Several plausible explanations exist for this apparent paradox, one of which is that the risk conveyed by genes involved in the development of hypertension is context dependent. This notion is supported by a growing number of published animal and human studies, although none has yet provided unequivocal evidence that genetic and environmental factors interact to influence the risk of primary hypertension in humans. In this review, an assumption is made that common genetic variation contributes meaningfully to the development of primary hypertension. The review focuses on (i) several methodological limitations of genetic association studies and (ii) the roles that geneenvironment interactions might play in the development of primary hypertension. The proceeding sections of the review examine the design features necessary for future studies to adequately test the hypothesis that genes for primary hypertension act in a context-dependent manner. Finally, an outline of how knowledge of gene-environment interactions might be used to optimize the prevention or treatment of primary hypertension is provided.

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“…Since one of the most likely mechanisms whereby physical activity leads to a reduction in blood pressure is weight loss, statistical analyses need to be adjusted for body mass index in order to reveal whether there is an independent effect of physical activity on blood pressure. However, only approximately half of the studies have adjusted their results for body mass index [71,77,78,81,[84][85][86][87][88][89]. Other studies adjusted mainly for age alone [67,75,80,90] or used no adjustments at all [54,69,72,73,83].…”

Section: Evidence From Cross-sectional Studiesmentioning

confidence: 99%

“…In addition, inadequate adjustments for confounding factors, especially for obesity and diet, may explain the inconsistent findings as well. However, only approximately half of the studies have adjusted their findings for body mass index [71,77,78,81,84,89]. None of the studies adjusted their results for waist circumference or waist-to-hip ratio.…”

Section: Evidence From Cross-sectional Studiesmentioning

confidence: 99%

Physical Activity and Hypertension: Evidence of Cross-Sectional Studies,Cohort Studies and Meta-Analysis

Barengo¹,

Hu²,

Tuomilehto

2007

CHYR

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Physical activity is a cost-effective way to decrease blood pressure since it possesses potential for having a major public health impact. Prospective studies, have demonstrated that moderate-to-vigorous intensity physical activity at baseline seem to be associated with a lower incidence of hypertension among white men regardless of body mass index. The data among women are controversial. Further, there is not enough evidence at this moment to conclude that high commuting or occupational physical activity would be associated with a reduced risk for incident hypertension. Intervention studies however, have demonstrated that increased physical activity reduces systolic and diastolic blood-pressure in hypertensive and normotensive individuals independently from weight loss. In light of the evidence from these studies, physical activity should be practiced at a moderate intensity level (min. 40% of VO2 max) three times per week and for session times of at least 30 minutes in order to reduce systolic and diastolic blood pressure. Thus, physical activity should be considered as an important measure for the prevention and treatment of hypertension. Physical activity is a costeffective way to decrease blood pressure since it possesses potential for having a major public health impact.

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Association Between Physical Activity and Blood Pressure Is Modified by Variants in the G-Protein Coupled Receptor 10

Cited by 25 publications

References 20 publications

Interaction Between an 11βHSD1 Gene Variant and Birth Era Modifies the Risk of Hypertension in Pima Indians

Interaction Between an 11βHSD1 Gene Variant and Birth Era Modifies the Risk of Hypertension in Pima Indians

Identifying genes for primary hypertension: methodological limitations and gene–environment interactions

Physical Activity and Hypertension: Evidence of Cross-Sectional Studies,Cohort Studies and Meta-Analysis

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