Familial aggregation of myocardial infarction and coaggregation of myocardial infarction and autoimmune disease: a nationwide population-based cross-sectional study in Taiwan

Abstract

ObjectiveThis study examined how a history of myocardial infarction (MI) in a person’s first-degree relatives affects that person’s risk of developing MI and autoimmune diseases.DesignNationwide population-based cross-sectional studySettingAll healthcare facilities in Taiwan.ParticipantsA total of 24 361 345 individuals were enrolled.MethodsUsing data from the National Health Insurance Research Database in Taiwan, we conducted a nationwide cross-sectional study of data collected from all beneficiaries in the Taiwan National Health Insurance system in 2015, of whom 259 360 subjects had at least one first-degree relative affected by MI in 2015. We estimated the absolute risks and relative risks (RRs) of MI and autoimmune disease in those subjects, and the relative contribution of genetic and environmental factors to their MI susceptibility.ResultsThe absolute risks of MI for subjects with at least one affected first-degree relative and the general population were 0.87% and 0.56%, respectively, in 2015. Patients with affected first-degree relatives were significantly associated with a higher RR of MI (1.76, 95% CI: 1.68 to 1.85) compared with the general population. There was no association with a higher RR of autoimmune disease. The sibling, offspring and parental MI history conferred RRs (95% CI) for MI of 2.35 (1.96 to 2.83), 2.21 (2.05 to 2.39) and 1.60 (1.52 to 1.68), respectively. The contributions of heritability, shared environmental factors and non-shared environmental factors to MI susceptibility were 19.6%, 3.4% and 77.0%, respectively.ConclusionsIndividuals who have first-degree relatives with a history of MI have a higher risk of developing MI than the general population. Non-shared environmental factors contributed more significantly to MI susceptibility than did heritability and shared environmental factors. A family history of MI was not associated with an increased risk of autoimmune disease.

Characteristics of LDL-C Elevation and the Treatment Outcomes of Rosuvastatin in Patients With Acute Myocardial Infarction at Tra Vinh General Hospital 2021-2022

“…The results are consistent with Friedlander Y's study with women with an average age of 37.7±5.3 years [7]. Wang CL et al studied 24,361,345 subjects with an average age of 41.7±15.6 [8]. This result is lower than that of Beheshti S et al [9], and Ekberg S et al [10].…”

Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus

“…Multiple lines of enquiry demonstrate loss of T and B cell tolerance in lupus. For example, the study of rare genetic variants associated with familial aggregation of lupus with other rheumatic autoimmune diseases identified regulation of T cell activation and T cell receptor (TCR) signaling as key underlying pathways (11). Furthermore, single cell transcriptomic analysis of peripheral blood (PB) identified antigen presenting cell, B cell and T cell dysregulation (12).…”

Multigenerational Health Research using Population-Based Linked Databases: An International Review

“…Three European sites (Denmark, Norway, Sweden) and three non-European sites (Canadian province of Manitoba, Taiwan, Australian state of Western Australia) have the unique capability to define familial relationships and objectively-measured health histories from administrative and healthcare electronic records. Studies from these sites have made important contributions to understanding associations between familial health histories and individual outcomes for a broad range of health conditions or life events [6][7][8][9][10][11][12][13][14].…”