Familial aggregation of food allergy and sensitization to food allergens: a family‐based study

Abstract

SummaryBackground-The increasing prevalence of food allergy (FA) is a growing clinical and public health problem. The contribution of genetic factors to FA remains largely unknown.

Allergic Rhinitis in Relation to Food Allergies: Pointers to future research

“…4,14 Although no specific genes have been identified, food allergies are at least in part genetically determined, with various studies confirming patterns of familial inheritance. 15,16 Polymorphisms in up to nine genes have been associated with the incidence or severity of food allergies, including the CD14, forkhead box P3, signal transducer and activator of transcription 6, serine protease inhibitor kazal type 5 and interleukin 10 genes. 17 However, most of these findings need to be replicated in other populations.…”

Alergia alimentaria en pediatría: recomendaciones para su diagnóstico y tratamiento. Texto completo

“…21 Los factores ambientales (dieta, tipo de parto, exposición al humo de tabaco y microorganismos) intervienen en el desarrollo intrauterino y en las primeras etapas de la vida y provocan cambios epigenéticos 22,23 que influyen en el equilibrio Th1/Th2 y aumentan o disminuyen el riesgo alérgico. 24,25 Cuando alergenos alimentarios atraviesan la mucosa intestinal enfrentan el tejido linfoide asociado al intestino (gut-associated lymphoid tissue; GALT, por sus siglas en inglés), donde son procesados por células presentadoras de antígenos que estimulan células T reguladoras y macrófagos, y producen tolerancia inmunológica, situación natural que sucede "por defecto".…”

Primary Prevention of Allergic Diseases: Dreams or Reality?

“…To date, the most studied immunobiological properties of Bifidobacteria, Lactobacilli and E. coli. Since the significance of the effect of normal microflora on the development of atopy does not cause doubt, it is necessary to find out what factors can affect its condition in children, especially young children [73][74][75][76][77][78]. An important factor that affects the attachment of normal microflora is the degree of childbirth at birth, type of birth, and the presence of breastfeeding.…”