Familial Aggregation of Eye-Tracking Endophenotypes in Families of Schizophrenic Patients

Hong, L. Elliot; Mitchell, Braxton D.; Avila, Matthew T.; Adami, Helene; McMahon, Robert P.; Thaker, Gunvant K.

doi:10.1001/archpsyc.63.3.259

Cited by 48 publications

(41 citation statements)

References 48 publications

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“…The extraretinal motion-processing deficit is thought to be directly related to the eye-tracking abnormality in schizophrenia. 30,31 Our method of measuring the SPEM function is a global measurement of the SPEM, which is adequate for genetic analysis. We were thus able to quantitatively calculate the degree of SPEM impairment based on the Ln S/N ratio of the SPEM curves.…”

Section: Discussionmentioning

confidence: 99%

Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality

et al. 2009

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Schizophrenia is a multifactorial disorder characterized by the contribution of multiple susceptibility genes that may act in conjunction with epigenetic processes and environmental factors. The catechol-O-methyltransferase (COMT) gene, which is located in the 22q11 microdeletion, has been considered as a candidate gene for schizophrenia because of its ability to degrade catecholamines, including dopamine. In a genetic analysis, neurophysiological endophenotype in schizophrenia, such as smooth pursuit eye movement (SPEM) disturbance, is considered to be a good trait marker, because it may be under more direct genetic control. This study was performed to examine the genetic association of COMT polymorphisms with the risk of schizophrenia and SPEM abnormality in a Korean population. Six single-nucleotide polymorphisms of COMT were genotyped by TaqMan assay. Their genetic effects on the risk of schizophrenia were analyzed in 354 patients and 396 controls using v 2 analyses. Among the schizophrenic patients, 166 subjects were selected for association analyses of COMT polymorphisms with SPEM abnormality. From the six COMT polymorphisms, rs6267 showed an association with the reduced risk of schizophrenia after correction (P corr ¼ 0.02). In analysis of SPEM abnormality, no significant associations were detected with COMT polymorphisms. The results of the present study provide the evidence that in a Korean population, COMT on the 22q11 locus is likely involved in the development of schizophrenia, but not in the SPEM function abnormality.

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Section: Discussionmentioning

confidence: 99%

Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality

et al. 2009

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“…60,61 Several studies have reported abnormalities of smooth pursuit eye movements in both patients and their relatives. 62,63 A second human-related endophenotype is impairment in the P300 response, which is an event-related potential that is thought to represent brain activity resulting from tasks that require information to be maintained in working memory.…”

Section: Endophenotypesmentioning

confidence: 99%

Contribution of nonprimate animal models in understanding the etiology of schizophrenia

Lazar

Neufeld²,

Cain³

2011

jpn

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“…The domains of pathology paradigm, in contrast to the disease entity paradigm, identifies several aspects of schizophrenia as pathology targets for treatment develop- None Depends on the measure usedFrecent studies with specific measures report high heritability (h 2 ¼ 0.7À0.9) (Hong et al, 2006).…”

Section: A Paradigm Shift To Facilitate Drug Discoverymentioning

confidence: 99%

The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities

Carpenter

Koenig

2007

Neuropsychopharmacol

185

128

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Familial Aggregation of Eye-Tracking Endophenotypes in Families of Schizophrenic Patients

Abstract: These results suggest that predictive pursuit may index stronger genetic effect and may be better suited for genetic studies than the traditional SPEM measure of maintenance pursuit gain.

Cited by 48 publications

References 48 publications

Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality

Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality

Contribution of nonprimate animal models in understanding the etiology of schizophrenia

The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities

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