Contribution of nonprimate animal models in understanding the etiology of schizophrenia

Lazar, Noah L.; Neufeld, Richard W. J.; Cain, Donald P.

doi:10.1503/jpn.100054

Cited by 18 publications

(14 citation statements)

References 335 publications

(411 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In line with previous studies (Meyer et al, 2005; Hsiao and Patterson, 2011), we observed significant increased basal locomotion, possibly modeling the stereotyped or perseverative behavior often seen in patients with schizophrenia (Lazar et al, 2011; Steeds et al, 2015). There was also a reduction of time in the center of the arena, suggesting anxious‐like behavior in these animals, mimicking the aversive states observed in patients (Achim et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

Silveira

Medeiros

Röpke

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Maternal immune activation (MIA) during pregnancy in rodents increases the risk of the offspring to develop schizophrenia-related behaviors, suggesting a relationship between the immune system and the brain development. Here we tested the hypothesis that MIA induced by the viral mimetic polyinosinic-polycytidylic acid (poly I:C) in early or late gestation of mice leads to behavioral and neuroanatomical disorders in the adulthood. On gestational days (GDs) 9 or 17 pregnant dams were treated with poly I:C or saline via intravenous route and the offspring behaviors were measured during adulthood. Considering the progressive structural neuroanatomical alterations in the brain of individuals with schizophrenia, we used magnetic resonance imaging (MRI) to perform brain morphometric analysis of the offspring aged one year. MIA on GD9 or GD17 led to increased basal locomotor activity, enhanced motor responses to ketamine, a psychotomimetic drug, and reduced time spent in the center of the arena, suggesting an increased anxiety-like behavior. In addition, MIA on GD17 reduced glucose preference in the offspring. None of the treatments altered the relative volume of the lateral ventricles. However, a decrease in brain volume, especially for posterior structures, was observed for one-year-old animals treated with poly I:C compared with control groups. Thus, activation of the maternal immune system at different GDs lead to neuroanatomical and behavioral alterations possibly related to the positive and negative symptoms of schizophrenia. These results provide insights on neuroimmunonological and neurodevelopmental aspects of certain psychopathologies, such as schizophrenia.

show abstract

Section: Discussionsupporting

confidence: 92%

Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

Silveira

Medeiros

Röpke

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…Animal models of psychiatric disorders simulate signs or symptoms of a psychiatric disorder to provide a preparation for testing specific etiological theories and underlying mechanisms of the disorder as well as for conducting preclinical drug evaluations (Eilam and Szechtman, 2005a; Jones et al, 2011; Lazar et al, 2011; McKinney, 1988; Szechtman and Eilam, 2005; Willner, 1984). The use of animal models in psychiatry has had a stormy history in part because of the need to work out their proper place in the context of psychiatry as a scientific discipline (Szechtman and Eilam, 2005).…”

Section: Introductionmentioning

confidence: 99%

Obsessive-compulsive disorder: Insights from animal models

Szechtman

Ahmari

Beninger

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes. (3) Features of spontaneous behavior in deer mice constitute a rich platform to investigate the neurobiology of OCD, social ramifications of a compulsive phenotype, and test novel drugs. (4) Studies in animal models for psychiatric disorders comorbid with OCD suggest comorbidity may involve shared neural circuits controlling expression of compulsive behavior. (5) Analysis of compulsive behavior into its constitutive components provides evidence from an animal model for a motivational perspective on OCD. (6) Methods of behavioral analysis in an animal model translate to dissection of compulsive rituals in OCD patients, leading to diagnostic tests.

show abstract

“…Основную сложность в воспроизведении в эксперименте коморбидной патологии представляет выбор адекватной модели шизофрении. На сегодняшний день в основе моделирования шизофрении на животных лежат три основных подхода [20]: нарушение обмена нейромедиаторов (главным образом, дофамин и глутамат), нарушения развития на разных этапах нейрогенеза и изменения в генах.…”

unclassified

Early social isolation increases alcohol preference in experiment

Kutcher

Egorov

Chernikova

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

Rats subjected to isolation significantly more of ten preferred alcohol in the «two-bottle» test after 0.5, 2 and 3 months of forced alcohol drinking. After the end of isolation and before forced alcohol drin-king, the experimental rats showed greater locomotor activity in the «open field» test. According to the exploratory activity and emotionality, the rats in both groups had no significant differences. The rats subjected to isolation, were significantly more sensitive to the sound stimulus and lingered ongerin the start area in the «open field». Thus, the combination of early social isolation and forced alcohol drinking leads to greater alcohol preference in experimental animals. Significant differences in alcohol preference were observed after the start of forced alcohol drinking while immediately after isolation the rats of both groups had no differences in their relation to alcohol. After 3.5 months of forced alcohol drinking, the isolated rats demonstrated decreased behavioral despair in the same test.

show abstract

Contribution of nonprimate animal models in understanding the etiology of schizophrenia

Cited by 18 publications

References 335 publications

Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

Obsessive-compulsive disorder: Insights from animal models

Early social isolation increases alcohol preference in experiment

Contact Info

Product

Resources

About