Familial aggregation of alopecia areata

Anzengruber, Florian; Maul, Julia‐Tatjana; Kamarachev, Jivko; Trüeb, Ralph M.; French, Lars E.; Navarini, Alexander

doi:10.1016/j.jaad.2005.12.007

Cited by 292 publications

(78 citation statements)

References 138 publications

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“…8,9 It has also been postulated that compromise of immune privilege in normal hair follicles, mediated in part by interferon-gamma (INF-g), 10 has a role in the susceptibility and pathogenesis of AA. 11,12 Considerable evidence indicates that genetic elements have a significant role in the etiology of AA, as evidenced by the recent identification of a number of suggested susceptibility loci, 13 the high incidence of positive family history in affected individuals 14,15 and high twin concordance rates. [16][17][18][19][20] Many epidemiologic studies have shown a higher prevalence of autoimmune diseases, such as vitiligo, thyroid disease and collagen vascular disease, in AA patients and unaffected relatives (UaR) 21,22 suggesting a genetic predisposition to autoimmunity associated with familial background of AA.…”

Section: Introductionmentioning

confidence: 99%

Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity

Coda¹,

Hysa²,

Seiffert-Sinha³

et al. 2010

Genes Immun

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Alopecia areata (AA) is an autoimmune hair loss disorder in which systemic disturbances have been described, but are poorly understood. To evaluate disease mechanisms, we examined gene expression in the blood of defined clinical subgroups (patchy AA persistent type, AAP, n ¼ 5; alopecia universalis, AU, n ¼ 4) and healthy controls (unaffected relatives, UaR, n ¼ 5; unaffected non-relatives, UaNR, n ¼ 4) using microarrays. Unsupervised hierarchical clustering separates all four patient and control groups, producing three distinct expression patterns reflective of 'inheritance', 'disease' and 'severity' signatures. Functional classification of differentially expressed genes (DEGs) comparing disease (AAP, AU) vs normal (UaR) groups reveals upregulation in immune response, cytokine signaling, signal transduction, cell cycle, proteolysis and cell adhesionrelated genes. Pathway analysis further reveals the activation of several genes related to natural killer-cell cytotoxicity, apoptosis, mitogen activated protein kinase, Wnt signaling and B-and T-cell receptor signaling in AA patients. Finally, 35 genes differentially expressed in AA blood overlap with DEGs previously identified in AA skin lesions. Our results implicate innate and adaptive immune processes while also revealing novel pathways, such as Wnt signaling and apoptosis, relevant to AA pathogenesis. Our data suggest that peripheral blood expression profiles of AA patients likely carry new biomarkers associated with disease susceptibility and expression.

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Section: Introductionmentioning

confidence: 99%

Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity

Coda¹,

Hysa²,

Seiffert-Sinha³

et al. 2010

Genes Immun

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“…AA olgularının çoğunluğu sporadik olarak ortaya çıkar. Pozitif aile öyküsü yapılan yayınlarda %4.6 ile %42 arasında değişmektedir (5,16,17). Küçük yayınlarda aile öyküsü görülme sıklığı daha fazla bulunmuştur (18)(19)(20).…”

Section: Discussionunclassified

Clinical Features and Prognosis of Juvenil Alopecia Areata Patients

Özden¹,

Bayramoglu²,

Aydın³

et al. 2010

Turk J Dermatol

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Objective: Although alopecia areata (AA) affects both adults and children, there is limited information about juvenile AA. In this study the properties of juvenile AA, associated diseases and trigger factors were reviewed. Material ve Methods:We have examined the data of 54 AA patients under 16 years of age. We have re-contacted these patients and evaluated the course of the features of the disease and collected information about triggering factors, starting age, attack number, alopecia type, severity and localization of disease duration, full blood count, biochemistry and thyroid function tests, family history and the prognosis in the following years. Results: We could not detect any significant relationship between the presence of a trigger factor and severity of the clinical picture. Similarly, no relationship between duration of illness, gender, and the trigger factor was found. Seven (12.96%) patients had an underlying endocrinological disease. There was no significant relationship between the severity of clinical condition and the endocrine disease. Sixteen patients (29.6%) had a family history of AA with 1.2. or 3 degree relatives. Conclusion: While disease duration, gender and trigger factors did not have a significant relationship, family history was found to affect clinical severity. Another striking result was the stable severity in the presence of trigger factors. (Turk J Dermatol 2010; 4: 60-5)

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“…3 AA'nın genetik yatkınlık zemininde gelişen, dokuya özgü otoimmün bir hastalık olduğuna dair kuvvetli kanıtlar mevcuttur. 4 Hastaların bir kısmında akut veya kronik psikoemosyonel stres AA'nın başlamasına ve/veya ilerlemesine yol açıyor olabilir. 1,[5][6][7] Psikolojik stresin, beyin ve deri arasında önemli bir bağlantı olan nöroendokrin sistem aracılığıyla inflamatuvar deri hastalıklarını tetikleyebileceği veya alevlendirebileceği öne sürülmektedir.…”

Section: Gi Riflunclassified

Alopesi Areata Hastalarında Psikiyatrik Belirtiler

Ari¹,

Çenesizoğlu²,

Denli³

2011

Turkderm

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ÖzetAmaç: Alopesi areata ani saç kayıpları ile seyreden kronik inflamatuvar bir hastalıktır. Emosyonel stresle ilişkili psikopatolojilerin ve strese duyarlılığı arttıran kişilik özelliklerinin alopesi areata ile ilişkisi olabileceğini düşündüren kanıtlar mevcuttur. Bu çalışmada, alopesi areata hastalarında ve sağlıklı kontrollerde anksiyete ve depresyon belirtilerinin şiddeti ile aleksitimik özelliklerin düzeyinin karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Elli alopesi areata hastası ile 30 sağlıklı gönüllüden oluşan katılımcılar Beck depresyon ölçeği, Beck anksiyete ölçeği ve Toronto aleksitimi ölçeği skorları ile karşılaştırılmıştır. Bulgular: Hasta ve kontrol grupları arasında anksiyete belirtilerinin şiddeti ve aleksitimik özelliklerin düzeyi bakımından istatistiksel olarak anlamlı farklılık bulunmadığı gözlenmiştir (sırasıyla p=0,053 ve p=0,120). Hastaların sergilediği depresif belirtilerin şiddeti sağlıklı kontrollere göre istatistiksel olarak anlamlı yüksek bulunmuştur (p=0,010) ve depresif belirtilerin şiddeti ile mevcut alopesi areata atağının süresi arasında istatistiksel olarak anlamlı bir ilişki bulunmadığı gözlenmiştir (p=0,873). Sum maryBackground and Design: Alopecia areata is a chronic inflammatory disease characterized by sudden hair loss. Existing evidence suggests that alopecia areata may be associated with personality traits altering the susceptibility to stress and psychiatric conditions associated with stress. The aim of this study was to compare the intensity of depressive and anxiety symptoms and the level of alexithymia in patients with alopecia areata and healthy control subjects. Materials and methods: Fifty patients with the diagnosis of alopecia areata and 30 healthy volunteers were compared in terms of scores of Beck depression inventory, Beck anxiety inventory, and Toronto alexithymia scale. Results: There were no statistically significant differences between alopecia areata cases and healthy controls regarding intensity of anxiety and level of alexythimia (p=0.053 and p=0.120, respectively). The intensity of depressive symptoms exhibited by alopecia areata patients was found to be significantly higher than that in healthy controls (p=0.010) and there was no statistically significant relationship between intensity of depressive symptoms and duration of the current alopecia areata episode (p=0.873). Conclusion: It is suggested that psychiatric evaluation should also be performed in all alopecia areata cases during the clinical follow-up period. (Turk derm 2011; 45: 203-5)

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Familial aggregation of alopecia areata

Cited by 292 publications

References 138 publications

Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity

Peripheral blood gene expression in alopecia areata reveals molecular pathways distinguishing heritability, disease and severity

Clinical Features and Prognosis of Juvenil Alopecia Areata Patients

Alopesi Areata Hastalarında Psikiyatrik Belirtiler

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