False tumor-positive lymph nodes in radioimmunodiagnosis and radioimmunoguided surgery: Etiologic mechanisms

Cornelius, Eugene A.; West, A. Brian

doi:10.1002/(sici)1096-9098(199609)63:1<23::aid-jso5>3.0.co;2-s

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…This difference was highly significant (p < 0.00001). These results appear to support the impression that the lack of tumor cells in TAG-72-positive lymph nodes submitted for routine histopathology was indicative of false positivity ( 44 , 46 – 48 ). However, numerous variables account for “false-negative” results, including lymph node size, size and location of the metastasis in the node, and the number of sections taken ( 9 , 49 – 52 ).…”

Section: Antigen-directed Cancer Surgery and Extent Of Diseasesupporting

confidence: 71%

“…The answer is controversial. Many TAG-72-positive TDLNs lacked tumor cells based on routine pathologic studies, indicating that the answer to this question is no ( 46 , 47 ). Our results from an unpublished survey of 599 consecutive TAG-72-positive specimens from 92 patients with either primary or recurrent CRC suggest that the answer is no.…”

Section: Antigen-directed Cancer Surgery and Extent Of Diseasementioning

confidence: 99%

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Survival Advantage Following TAG-72 Antigen-Directed Cancer Surgery in Patients With Colorectal Carcinoma: Proposed Mechanisms of Action

et al. 2021

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Patients with colorectal carcinoma (CRC) continue to have variable clinical outcomes despite undergoing the same surgical procedure with curative intent and having the same pathologic and clinical stage. This problem suggests the need for better techniques to assess the extent of disease during surgery. We began to address this problem 35 years ago by injecting patients with either primary or recurrent CRC with 125I-labeled murine monoclonal antibodies against the tumor-associated glycoprotein-72 (TAG-72) and using a handheld gamma-detecting probe (HGDP) for intraoperative detection and removal of radioactive, i.e., TAG-72-positive, tissue. Data from these studies demonstrated a significant difference in overall survival data (p < 0.005 or better) when no TAG-72-positive tissue remained compared to when TAG-72-positive tissue remained at the completion of surgery. Recent publications indicate that aberrant glycosylation of mucins and their critical role in suppressing tumor-associated immune response help to explain the cellular mechanisms underlying our results. We propose that monoclonal antibodies to TAG-72 recognize and bind to antigenic epitopes on mucins that suppress the tumor-associated immune response in both the tumor and tumor-draining lymph nodes. Complete surgical removal of all TAG-72-positive tissue serves to reverse the escape phase of immunoediting, allowing a resetting of this response that leads to improved overall survival of the patients with either primary or recurrent CRC. Thus, the status of TAG-72 positivity after resection has a significant impact on patient survival.

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Section: Antigen-directed Cancer Surgery and Extent Of Diseasesupporting

confidence: 71%

Section: Antigen-directed Cancer Surgery and Extent Of Diseasementioning

confidence: 99%

Survival Advantage Following TAG-72 Antigen-Directed Cancer Surgery in Patients With Colorectal Carcinoma: Proposed Mechanisms of Action

et al. 2021

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“…More detailed mechanisms for the false‐positive detection of lymph nodes using RIGS have been suggested [ 32]. First, shed TAA can pass to the lymph nodes where it is available for binding by the radioantibody.…”

Section: False‐positive Lymph Node Detectionmentioning

confidence: 99%

Radioimmunoguided surgery (RIGS) in the clinical management of colorectal cancer

1999

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AntiTumor-Associated Antigens IGGS: Dual Positive and Negative Potential Effects for Cancer Therapy

Guillem¹,

Sampsel²

2006

New Trends in Cancer for the 21st Century

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False tumor-positive lymph nodes in radioimmunodiagnosis and radioimmunoguided surgery: Etiologic mechanisms

Cited by 7 publications

References 28 publications

Survival Advantage Following TAG-72 Antigen-Directed Cancer Surgery in Patients With Colorectal Carcinoma: Proposed Mechanisms of Action

Survival Advantage Following TAG-72 Antigen-Directed Cancer Surgery in Patients With Colorectal Carcinoma: Proposed Mechanisms of Action

Radioimmunoguided surgery (RIGS) in the clinical management of colorectal cancer

AntiTumor-Associated Antigens IGGS: Dual Positive and Negative Potential Effects for Cancer Therapy

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