False Positive Values of Biomarkers of Prenatal Screening on Chromosomopathy as Indicators of a Risky Pregnancy

Durkovic, Jasmina; Anđelić, Luka; Mandić, Bojana; Lazar, Denis

doi:10.2478/v10011-011-0010-x

Cited by 2 publications

(3 citation statements)

References 8 publications

(7 reference statements)

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“…Higher levels of free ß-hCG (> 2.5 MoM) can also indicate the risk of preeclampsia. 6 In our results, free ß-hCG in the preeclampsia group of pregnant women was increased but it was not statistically significant, according to Mann-Whitney test (p=0.294) and Kolmogorov-Smirnov test (p = 0.397).…”

Section: Discussioncontrasting

confidence: 65%

“…Free ß-hCG often has false positive values greater than 2.0 MoM, and it requires a necessary correct interpretation and determination of the correlation between its value and the state of pathological pregnancy. [4][5][6] Data from the literature show that increased levels of hCG, regardless if the total or free ß-hCG subunit is being measured, are indicators of fetal hypoxia. Higher levels of free ß-hCG (> 2.5 MoM) can also indicate the risk of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…The combined screening test is used for the early detection of risk for chromosomal abnormalities (trisomies 21, 18 and 13) in prenatal diagnosis and includes measuring of biochemical markers PAPP-A and free beta-hCG from the serum, and ultrasound parameters (nuchal translucency thickness, NT, and crown-rump length, CRL ). [4][5][6] In the group with preeclampsia, the youngest pregnant wo man was 21 and the oldest 46 years old. In the control group, the youngest pregnant woman was 20 and the oldest 38 years old.…”

Section: Methodsmentioning

confidence: 99%

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The Combined Screening Test in the First Trimester of Pregnancy and Preeclampsia

Djordjevic¹,

Draganović²

2015

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Introduction: The combined screening test in the first trimester of pregnancy and determination of biochemical markers, pregnancy-associated plasma protein-A (PAPP-A) and free beta subunit of human chorionic gonadotropin (free ß-hCG) were measured to assess the risk for developing hypertensive disorders during pregnancy after 20 weeks of gestation. Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality. Aim of the study: To present obtained results of biochemical markers (PAPP-A and free ß-hCG) taken from a serum of pregnant women with preeclampsia in the first trimester of pregnancy and to examine the correlation between biochemical markers, age of the pregnant woman and body mass index (BMI) with preeclampsia. Patients and methods: This retrospective study included 70 pregnant women in two groups: (1) preeclampsia group (n=40), (2) control group (n=30). Results: In the preeclampsia group, the mean value of free ß-hCG was 37.18±20.64 IU/L and for PAPP-A 2711.15±1788.60 mIU/L with a statistical significance of p=0.007, compared to the control group. The mean value of body mass index (BMI) was 26.18±4.93 kg/m² and for age 31.53±5.00 years. In the control group, the mean value of free ß-hCG was 29.97±10.39 IU/L and for PAPP-A 3411.30±1227.59 mIU/L. The mean value of body mass index (BMI) was 23.47±4.09 kg/m² and for age of pregnant women 28.10±4.57 years. Conclusion: There is a significant association between the low level of biochemical marker PAPP-A in serum and the risk for PE. The difference of values of free ß-hCG between the groups tested was not statistically significant. Maternal age and body mass index (BMI) are confirmed risk factors for development of PE. The combined screening test contributes to the prevention of PE, with the goal of improving health of pregnant women.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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