False-positive rapid plasma reagin testing in patients with acute Plasmodium vivax malaria: A case control study

Maves, Ryan C; Dean, Katherine; Gadea, Nilda; Halsey, Eric S.; Graf, Paul C. F.; Lescano, Andrés G.

doi:10.1016/j.tmaid.2013.10.010

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…Unlike the prevalence of other types of RTIs at a relatively lower level, the positive rate of syphilis (0.73%) was high in our study population, and it was also much higher than the national level from 2010 to 2012 in China (0.37%) [ 18 ]. However, according to the local study site staff feedback, some of the positive syphilis cases were only based on the RPR test and were not confirmed by TPPA, indicating that our estimated prevalence of syphilis might have been overestimated with a false positive rate of approximately 5–10%, as previous studies reported [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 58%

Prevalence of reproductive tract infections among women preparing to conceive in Chongqing, China: trends and risk factors

Zeng

Yang

et al. 2022

Reprod Health

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Background Reproductive tract infection has become a major public health issue all over the world for its high and growing prevalence. It can cause adverse pregnancy outcomes in pregnant women and their foetuses. This study aimed to investigate the trends and risk factors of the prevalence of reproductive tract infections among women who prepared to conceive in the Chongqing Municipality (China) from 2012 to 2016. Methods A multi-center cross-sectional study was conducted between January 2012 and December 2016. Women aged 20–49 years who intended to get pregnant were recruited for this study. All participants underwent preconception examination, which included testing for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, syphilis, bacterial vaginosis and candidiasis according to the national diagnostic standard. A total of 439,372 women with testing results for all six types of reproductive tract infections were included in our final analyses. Logistic regression and factor analysis were used to determine the possible sociodemographic factors associated with prevalence trends. Results In our study, the overall positive rate of RTIs among the 439,372 women of reproductive age was 5.03%. Candidiasis was the most common infection in our population (2.47%), followed by bacterial vaginosis (1.28%), syphilis (0.73%), T. vaginalis (0.49%), C. trachomatis (0.20%) and N. gonorrhoeae (0.06%). The prevalence of reproductive tract infections was highest among women aged 35 years and above, with a primary or lower education level, history of pregnancy, delivery, induced abortion, or spontaneous abortion. From 2012 to 2016, the trend of the overall prevalence of reproductive tract infections was V-shaped, decreasing steadily from 2012 to 2015, with a slight rise in 2016. Our results suggest that the distribution change of age, education level, gravidity, parity, and history of induced abortion influenced this trend. Conclusion Since the number of high-risk women who intend to become pregnant is growing in the Chongqing Municipality, pre-conception positive preventions including health education, regular screening, and timely treatment of reproductive tract infections are needed to prevent the impact of reproductive tract infections on maternal health and infant safety.

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Section: Discussionmentioning

confidence: 58%

Prevalence of reproductive tract infections among women preparing to conceive in Chongqing, China: trends and risk factors

Zeng

Yang

et al. 2022

Reprod Health

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“…To the best of our knowledge, there have only been previous case reports [11] and clinical expert guidance [2] for these outcomes, not retrospective reviews of results. Other studies also reviewed false-positive results related to the RPR [12,13], not the reverse algorithm. Our findings, in contrast, constitute what we believe is the first study to categorize inconclusive syphilis results for an entire public health unit based on the frequency of the various possible causes of such results and the risk factors associated with these outcomes.…”

Section: Discussionmentioning

confidence: 99%

Inconclusive Syphilis Results: A Retrospective Review of Public Health Results

O’Byrne

Tilley

Friedman

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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In the context of increasing syphilis incidence in many Western countries, we sought to better understand the frequency and outcomes associated with inconclusive serologic syphilis results. To accomplish this, we reviewed all inconclusive results that arose from an indeterminant confirmatory treponemal screen (specifically the Treponema pallidum particulate agglutination test), which were reported to Ottawa Public Health from January 1, 2019, through December 31, 2019. Our case review identified that 52 persons generated such test results during the study period, of whom 44.4% were cases requiring treatment, 46.3% were persons without new risk factors or symptoms of syphilis who had been previously treated for this infection, and 9.3% were not syphilis. Overall, these untreated syphilis cases accounted for 8.6% of all new syphilis diagnoses in our local jurisdiction during the study period. These results highlight that case investigation and prompt management of inconclusive syphilis results is an appropriate public health and clinical approach and that such a strategy could contribute to efforts to reduce increasing syphilis incidence.

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“…41 Hasil positif palsu sebesar 8,2% dari RPR terlihat pada pasien malaria Plasmodium vivax. 14 Titer RPR ≤1:4 tampak pada sebagian besar hasil positif palsu pemeriksaan serologis non spesifik treponema, 39 namun, pada literatur ini didapatkan setengah dari hasil positif palsunya memiliki titer RPR ≥1:8. 14 Oleh karena itu, pemeriksaan ulang disarankan untuk dilakukan dan dilanjutkan dengan pemeriksaan serologis spesifik treponema.…”

Section: Bahasanunclassified

Efektivitas Pemeriksaan Serologis Sifilis

Baguna¹,

Niode²,

Pandaleke³

2021

eCL

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High prevalence of syphilis can be reduced by doing screening. Tests used for screening and diagnosis of syphilis are serological tests of syphilis consisting of nontreponemal tests and treponemal tests. Nontreponemal tests consist of Rapid Plasma Reagin (RPR) and Venereal Disease Research Laboratory (VDRL) meanwhile Treponemal tests consist of Treponema Pallidum Haemagglutination Assay (TPHA) and Treponema Pallidum Rapid (TP Rapid). This study was aimed to determine the effectiveness of syphilis serological tests. This was a literature review study using the keywords namely serology OR serological OR serologic AND syphilis in PubMed and ClinicalKey. The literatures were written in English and/or Indonesian, published in the last 10 years (2011-2020), and can be accessed in full text. The results obtained 25 literatures. High sensitivity was found in RPR of 9.1%-100%, VDRL of 44.4% -100%, and TP Rapid of 50.0%-100%. High specificity was found in TPHA of 99.7% and TP Rapid of 85.3% -100%. In conclusion, effective syphilis screening is performed with RPR and VDRL, while effective syphilis diagnostic is performed with TP Rapid and TPHA.Keywords: syphilis, serology tests, effectiveness of tests Abstrak: Prevalensi kasus sifilis yang tinggi dapat diturunkan dengan adanya skrining. Pemeriksaan yang digunakan untuk skrining dan diagnosis sifilis ialah pemeriksaan serologis sifilis, terdiri atas pemeriksaan serologis non spesifik treponema dan pemeriksaan serologis spesifik treponema. Pemeriksaan serologis non spesifik treponema antara lain Rapid Plasma Reagin (RPR) dan Venereal Disease Research Laboratory (VDRL). Pemeriksaan serologis spesifik treponema antara lain Treponema Pallidum Haemagglutination Assay (TPHA) dan Treponema Pallidum Rapid (TP Rapid). Penelitian ini bertujuan untuk mengetahui efektivitas pemeriksaan serologis sifilis. Jenis penelitian ialah literature review menggunakan kata kunci serology OR serological OR serologic AND syphilis di PubMed dan ClinicalKey. Literatur yang digunakan memiliki bahasa Inggris dan/atau bahasa Indonesia, terbitan 10 tahun terakhir (2011-2020), dan dapat diakses teks lengkap. Sensitivitas tinggi ditemukan pada RPR sebesar 9,1%-100%, VDRL sebesar 44,4%-100%, dan TP Rapid sebesar 50,0%-100%. Spesifisitas tinggi ditemukan pada TPHA sebesar 99,7% dan TP Rapid sebesar 85,3%-100%. Simpulan penelitian ini ialah skrining sifilis efektif dilakukan dengan RPR dan VDRL, sedangkan diagnostik sifilis efektif dilakukan dengan TP Rapid dan TPHA.Kata kunci: sifilis, pmeriksaan serologis, efektivitas pemeriksaan

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False-positive rapid plasma reagin testing in patients with acute Plasmodium vivax malaria: A case control study

Cited by 12 publications

References 29 publications

Prevalence of reproductive tract infections among women preparing to conceive in Chongqing, China: trends and risk factors

Prevalence of reproductive tract infections among women preparing to conceive in Chongqing, China: trends and risk factors

Inconclusive Syphilis Results: A Retrospective Review of Public Health Results

Efektivitas Pemeriksaan Serologis Sifilis

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