False-Positive I-131 Deposition in a Parotid Gland Duct Ectasia

Wolff, H; Breda, D. J.; Silva, N. Da; Hartmann, A. A.

doi:10.1097/00003072-199804000-00023

Cited by 11 publications

(4 citation statements)

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“…3 , Table 1 ). Radioiodine uptake in non-thyroid cancer lesions has been reported in a large number of cases, including a bronchogenic cyst and a parotid gland duct ectasia that accumulated fluids possibly via the sodium iodide symporter, the major gatekeeper of iodine uptake in thyroid cells ( 15 16 17 ). On the other hand, F-18 uptake has been reported in diverse benign bone diseases ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy

Lee

Park

et al. 2016

Korean J Radiol

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ObjectiveThe aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis.Materials and MethodsWe retrospectively enrolled 6 thyroid cancer patients (age = 44.7 ± 9.8 years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients.ResultsOf the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05).ConclusionBone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.

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Section: Discussionmentioning

confidence: 99%

F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy

Lee

Park

et al. 2016

Korean J Radiol

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“…In lower mediastinal region, retention of gastric juice in herniated stomach or gastric volvulus can lead to false-positive I-131 scanning results. [ 9 10 11 ] Therefore, recognition of potential false-positive iodine-131 scans especially in the lower mediastinal region is critical to avoid additional costly investigations and unnecessary exposure to repeated therapeutic doses of radioactive iodine.…”

Section: Discussionmentioning

confidence: 99%

Hiatal hernia uptake of iodine-131 mimicking mediastinal metastasis of papillary thyroid carcinoma

Haghighatafshar

Khajehrahimi

2015

Indian J Nucl Med

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There are a few case reports of hiatal hernia demonstrating thoracic uptake on I-131 scintigraphy. In this case, high thyroglobulin levels in combination with misinterpretation of I-131 uptake in the mediastinum, leaded to mismanagement of the patient. Here we present a case of focal I-131 uptake within a hiatal hernia initially mimicking an isolated mediastinal metastasis. There are many potential causes of false-positive I-131 scan result. In this case, adjunctive chest computed tomography and gastroesophageal barium study helped to elucidate the true nature of this I-131 uptake. False-positive findings may be caused by a wide variety of nonthyroidal carcinomas, which can concentrate radioiodine or from skin contamination. Several organs, such as the gastric, salivary glands, renal cyst, pericardial effusion, and ovarian can accumulate I-131. It should be borne in mind as a potential source of false-positive whole-body I-131 imaging.

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“…In many cases, the iodine uptake may be due to the expression of the sodium/ iodine symporter (NIS) in ectopic thyroid tissue as well as in non-thyroidal normal or pathological tissues (5,10-12). In some instances, foci of 131 I activity are not related to the presence of NIS, but due to retention of radioiodine in physiologic body fluids accumulated in ducts or cavities (13,14) as well as contamination by physiologic secretions (5). In addition, it has also reported radioiodine trapping in various inflamed tissues and/or cysts because of their increased vascularity and capillary permeability (15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Abnormal radioiodine uptake on post-therapy whole body scan and sodium/iodine symporter expression in a dermoid cyst of the ovary: report of a case and review of the literature

Campennì

Giovinazzo

Tuccari

et al. 2015

Arch. Endocrinol. Metab.

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SUMMARYIn patients affected by differentiated thyroid cancer, the whole-body scan (WBS) with 131-radioiodine, especially when performed after a therapeutic activity of 131 I, represents a sensitive procedure for detecting thyroid remnant and/or metastatic disease. Nevertheless, a wide spectrum of potentially pitfalls has been reported. Herein we describe a 63-year-old woman affected by follicular thyroid cancer, who was accidentally found to have an abdominal mass at post-dose WBS (pWBS). pWBS showed abnormal radioiodine uptake in the upper mediastinum, consistent with lymph-node metastases, and a slight radioiodine uptake in an abdominal focal area. Computed tomography revealed an inhomogeneous mass in the pelvis, previously unrecognized. The lesion, surgically removed, was found to be a typical dermoid cyst of the ovary, without any evidence of thyroid tissue. By immunohistochemistry, a moderate expression of the sodium-iodine symporter (NIS) was demonstrated in the epithelial cells, suggesting a NIS-dependent uptake of radioiodine by the cyst. Arch Endocrinol Metab.2015;59(4):351-4

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False-Positive I-131 Deposition in a Parotid Gland Duct Ectasia

Cited by 11 publications

References 1 publication

F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy

F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy

Hiatal hernia uptake of iodine-131 mimicking mediastinal metastasis of papillary thyroid carcinoma

Abnormal radioiodine uptake on post-therapy whole body scan and sodium/iodine symporter expression in a dermoid cyst of the ovary: report of a case and review of the literature

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