F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy

Abstract

ObjectiveThe aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis.Materials and MethodsWe retrospectively enrolled 6 thyroid cancer patients (age = 44.7 ± 9.8 years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients.ResultsOf the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05).ConclusionBone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.

Imaging of Myocardial Ischemia–Reperfusion Injury Using Sodium [18F]Fluoride Positron Emission Tomography/Computed Tomography in Rats and Humans

“…However, previous experimental studies strongly suggest the usefulness of CysA for IRI. [19][20][21][22][23][24] Sodium [ 18 F]fluoride PET/CT may facilitate the development of anti-IRI therapy by objectively demonstrating the PCI effect, unveiling the final integrated result of the original ischemic injury and the reperfusion injury post-PCI. Furthermore, the pattern and location of Na[ 18 F]F uptake may provide the cardiologist with valuable information regarding the PCI effect as seen in our results (Figure 3), which is not possible by only measuring the blood markers of myocardial injury.…”

Selection and Reporting of Statistical Methods to Assess Reliability of a Diagnostic Test: Conformity to Recommended Methods in a Peer-Reviewed Journal

“…Regarding the DTA studies, one reviewer experienced in DTA studies selected eligible articles according to criteria established elsewhere ( 9 ) with additional confirmation by another DTA expert in cases of ambiguity. Of the initial 124 candidate articles, 63 articles ( 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 ) were finally included. Regarding the studies that analyzed reliability, eligible articles were chosen by consensus after review by two of four independent reviewers experienced in the relevant methodology.…”

New insight into biology, molecular diagnostics and treatment options of unstable carotid atherosclerotic plaque: a narrative review

“…Another less used type of positron emission tomography procedure with application of F-18 sodium fluoride ([ 18 F] NaF) is able to detect microcalcific deposits in the plaque fibrous cap which are responsible for increased mechanical stress leading to a cap rupture (28). [ 18 F] NaF was originally developed as a hydroxyapatite-seeking agent for the evaluation of bone and joint diseases but secondarily it turned out that it is taken up by active microcalcification characteristic of vulnerable plaque (28,(48)(49)(50).…”