False-negative metaiodobenzylguanidine scintigraphy at diagnosis of neuroblastoma

Integrated Imaging Using MRI and 123| Metaiodobenzylguanidine Scintigraphy to Improve Sensitivity and Specificity in the Diagnosis of Pediatric Neuroblastoma

“…2). These findings are concordant with published studies showing the difficulties in differentiating liver metastases from physiologic uptake in the liver [20,21] and a general false-negative rate of 8-10% on MIBG scintigraphy [12,22].…”

“…1). Possible reasons for the limited detection rate of bone metastases are the coexistence of hot and cold MIBG lesions in the same patient [12] and metabolic changes of the tumor and its foci under treatment [20].…”

“…Scintigraphy with 123 I-or 131 I-labeled MIBG has become a well-established method in the diagnosis and staging of neuroblastoma [12] because of its high spec-…”

Outcome and Prognostic Features in Opsoclonus-Myoclonus Syndrome From Infancy to Adult Life

“…[9][10][11] Low-grade tumors are typically metabolically inactive and difficult to detect with metaiodobenzylguanidine scintigraphy and urinary catecholamine studies. 12,13 Recent evidence suggests that at least 20% of OMS cases have an atypical presentation, and the time to diagnosis is frequently delayed by weeks or months. 4,13 In contrast to acute cerebellar ataxia, the outcome of OMS is far more disabling.…”

Simultaneous Occurrence of Pancreatoblastoma and Neuroblastoma in a Newborn With Beckwith-Wiedemann Syndrome

“…The tumor spontaneously regresses without treatment in approximately 50% of cases, as recently reported by the German Group. [13][14][15] At this age, the I 123 meta-iodo-benzylguanidine scan is often negative, most likely due to the different uptake of meta-iodo-benzylguanidine in the newborn, 16 and urinary catecholamine levels are elevated in only about 50% of cases. Both of these characteristics were present in our patient.…”