Outcome and Prognostic Features in Opsoclonus-Myoclonus Syndrome From Infancy to Adult Life

Brunklaus, Andreas; Pohl, Keith; Zuberi, Sameer M.; Sousa, Carlos de

doi:10.1542/peds.2010-3114

Cited by 97 publications

(132 citation statements)

References 34 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Opsoclonus myoclonus have substan al developmental sequelae includes cogni ve, motor, speech and language defi cits, and behavioural sequelae 9 . About 61% have chronic relapsing course, half have intellectual defi cit and more than half have residual motor and speech defi cits 10 .…”

Section: Discussionmentioning

confidence: 99%

Opsoclonus Myoclonus Ataxia Syndrome

Kunchapudi

Kumar

Sabharwal

2015

J. Nepal Paedtr. Soc.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Opsoclonus Myoclonus Ataxia Syndrome

Kunchapudi

Kumar

Sabharwal

2015

J. Nepal Paedtr. Soc.

View full text Add to dashboard Cite

show abstract

“…Hastalarımızda medulla spinalis basısına ek olarak ataksi ve opsoklonus, ani görme kaybı ve nöbet geçirme yakınmaları birer hastada başvuru sebebi olmuştur. Opsoklonus, miyoklonus ve ataksi NBL'da tanımlanan paraneoplastik sendromlardan biridir (12). Bu çocuklarda ani spontan, konjuge göz hareketleri, ekstremite ve gövde kaslarında düzensiz kasılmalar gözlenir.…”

Section: Bulgularunclassified

“…Bu çocuklarda ani spontan, konjuge göz hareketleri, ekstremite ve gövde kaslarında düzensiz kasılmalar gözlenir. Serimizde %0,9 oranında saptanan bu bulgu bazı yayınlarda %5-9 oranında bildirilmektedir (1,12). Optik sinirlere bası, evre 4 NBL'lu olgumuzda körlüğe neden olmuştur.…”

Section: Bulgularunclassified

See 1 more Smart Citation

The Clinical Characteristics of Children with Neuroblastoma

Sevinir¹,

Demirkaya²,

Güler³

et al. 2013

jcp

View full text Add to dashboard Cite

ÖZETGi rifl: Bu çalışmanın amacı nöroblastomlu (NBL) çocuklarda tanısal özelliklerin belirlenmesidir. Gereç ve Yöntem: Hastaların kayıtları retrospektif olarak değerlendirildi. Yaş, başvuru yakınmaları ve süreleri, tümör yerleşimi ve evre belirlendi. Hemogram, laktat dehidrogenaz (LDH) ve VMA sonuçları kaydedildi. Veriler istatistiksel olarak karşılaştırıldı. Bulgular: NBL'lu 115 hastanın ortalama yaşı 2,57±2,49 yıl (sınırlar 0-12) olup %32'si bir yaşından, %89'u ise beş yaşından küçüktü. Hastaların %74,8'inde abdominal (%66'sı adrenal, %8,8'i adrenal dışı), %12'sinde paraspinal, %7'sinde mediastinal ve %3,5'inde pelvik kitle saptandı. Olguların %30,4'ünde evre 1 ve 2, %13'ünde evre 3, %46,1'inde evre 4 ve %10,4'ünde evre 4S hastalık belirlendi. Olguların %11'i klinik özellikler, sitolojik bulgular ve VMA ölçümü ile tanı aldı. VMA yüksekliği %83 oranında idi. Ortanca yakınma süresi 6,5 hafta olarak bulundu. En sık gözlenen yakınmalar solukluk, karın şişliği, karın ağrısı ve kemik ağrısı idi. Sonuç: NBL küçük çocukların tümörüdür. Primer yerleşime ve yaygınlığa göre klinik bulgular değişmektedir. Anemi, karın ağrısı ve kemik ağrıları uyarıcı bulgulardır. (Gün cel Pe di at ri 2013; 11: 6-12) Anah tar ke li me ler: Nöroblastom, klinik özellikler, metastaz SUM MARYIn tro duc ti on: The aim of this study was to evaluate the diagnostic characteristics of children with neuroblastoma (NBL). Materials and Methods: Hospital records were reviewed retrospectively. Age, symptoms and their durations, tumor site, stage and results of complete blood count, LDH and VMA were recorded. Statistical comparisons and calculations were made. Results: The mean age at diagnosis was 2.57±2.49 yrs (ranges 0-12). Of children, 89% were under 5 years and 32% were below 1 year. The most common tumor sites were abdomen [74.8%; (adrenal 66%), (non-adrenal 8.8%)], paraspinal region (12%), chest (7%) and pelvis (3.5%). Most of the tumors were in advanced stage (stage 1 and 2= 30.4 %, stage 3 and 4=13% and 46,1% and stage 4S=10.4%). The diagnosis was made from bone marrow cytology and increased VMA in 11% of the cases. VMA level was high in 83% of the patients. Median duration of symptoms was 6.5 weeks. The most frequent complaints were pallor, abdominal mass, abdominal pain and bone pain. Conclusions: NBL mainly involves young children. Clinical presentation varies with primary tumor site and dissemination. Anemia, abdominal and bone pain have diagnostic signifi cance. (Jo ur nal of Cur rent Pe di at rics 2013; 11: 6-12)

show abstract

“…In children, OMS was associated with neuroblastoma; in adults it may be associated with breast carcinoma or small-cell lung carcinoma, uterus or ovarian cancers, rare gall bladder, pancreas and renal cell carcinoma. It can also be consequent to toxic medication (amitriptyline, haloperidol, diazepam), metabolic disorders [1], hydroelectrolytic disorders, brain anoxia or autoimmune cause – Hashimoto's encephalopathy [2], autoantibodies against neurons and cerebellar Purkinje cells [3], celiac disease, and one of the paraneoplastic syndromes. Although it is not considered an infectious disease, it can be associated with some viral infections, which may trigger the debut of OMS [4], such as the Epstein–Barr virus, coxsackie B2, B3 virus, Saint Louis encephalitis virus, human immunodeficiency virus [1], hepatitis C infection [5], rubella, mumps [6], varicella-zoster virus [7], and West Nile virus [8].…”

Section: Introductionmentioning

confidence: 99%

Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report

Bîrluțiu

Bîrluţiu

2014

J Med Case Reports

View full text Add to dashboard Cite

IntroductionOpsoclonus-myoclonus syndrome is a very rare neurological disorder associated with some viral infections and exceptionally with the West Nile virus.Case presentationA 57-year-old Caucasian woman presented with fever, dizziness, balance difficulties, vomiting, dancing eye, altered speech, tremor, generalized myoclonus and failure to rise or stand. Our objective is to describe a patient with West Nile infection, which was identified both in her serum and cerebrospinal fluid and was associated with encephalitis and opsoclonus-myoclonus-ataxia syndrome.ConclusionsOpsoclonus-myoclonus-ataxia syndrome continued for 4 weeks after onset, when she died. There was no evidence for any other etiology responsible for her opsoclonus-myoclonus syndrome. Her opsoclonus-myoclonus syndrome appeared associated with West Nile encephalitis and had an unfavorable evolution despite treatment.

show abstract

Outcome and Prognostic Features in Opsoclonus-Myoclonus Syndrome From Infancy to Adult Life

Cited by 97 publications

References 34 publications

Opsoclonus Myoclonus Ataxia Syndrome

Opsoclonus Myoclonus Ataxia Syndrome

The Clinical Characteristics of Children with Neuroblastoma

Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report

Contact Info

Product

Resources

About