Fall time may be a reliable discriminator between neoplastic and non‐neoplastic urinary bladder lesions in dogs undergoing contrast‐enhanced ultrasound: a pilot study

Spediacci, Carlotta; Manfredi, M.; Sala, Giulia; Liuti, Tiziana; Israeliantz, Nicolas; Zani, Davide Danilo; Giancamillo, M. Di; Longo, Maurizio

doi:10.1111/vru.13105

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…In the urinary bladder, evaluated with CEUS, a faster transit time (wash in, peak, and wash out) was associated with malignant lesions when compared to that of inflammatory lesions [57].…”

Section: Kidneys and Urinary Bladdermentioning

confidence: 93%

Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

Ercolin,

Uchôa,

Aires

et al. 2024

Animals

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The aim of this literature review was to present the novel imaging modalities elastography and contrast-enhanced ultrasonography. We provided an overview of the concepts and applications of each technique for the investigation of neoplastic and metastatic tumors in dogs and cats. Studies on elastography are based on the elasticity and deformation of the evaluated tissue. The information obtained from the different types of elastography can aid in the detection and differentiation of malignant and benign structures. Descriptions of elastography studies in several organs and tissue in veterinary medicine reported that, in general, malignant tumors tend to be more rigid and, therefore, less deformable than benign lesions or in comparison to the healthy parenchyma. Contrast-enhanced ultrasonography is based on the intravenous injection of contrast media constituted by microbubbles. This imaging modality can be performed in nonsedated animals and provides information on the tissue perfusion, allowing the investigation of macro- and micro-circulation. Studies on different organs and tissues were performed in dogs and cats and revealed a tendency of malignant tumors to present faster transit of the contrast media (time to wash-in, peak and wash-out). These advanced techniques can be associated with other imaging modalities, aiding important information to the well-established exams of B-mode and Doppler ultrasonography. They can be used as screening tests, potentially representing an alternative to the invasive sampling methods required for cytological and histopathological analysis.

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“…In the urinary bladder, evaluated with CEUS, a faster transit time (wash in, peak, and wash out) was associated with malignant lesions when compared to that of inflammatory lesions [57].…”

Section: Kidneys and Urinary Bladdermentioning

confidence: 93%

Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

Ercolin,

Uchôa,

Aires

et al. 2024

Animals

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Fall time may be a reliable discriminator between neoplastic and non‐neoplastic urinary bladder lesions in dogs undergoing contrast‐enhanced ultrasound: a pilot study

Spediacci

Manfredi

Sala

et al. 2022

Vet Radiology Ultrasound

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Contrast-enhanced ultrasound (CEUS) can provide quantitative information on enhancement patterns and perfusion of lesions, based on time-intensity curves (TICs). No published studies have compared CEUS parameters in neoplastic and non-neoplastic urinary bladder lesions in dogs. The aim of the current prospective, pilot study was to quantitatively characterize the CEUS pattern of neoplastic and non-neoplastic urinary bladder lesions in dogs, assessing the influence of contrast arrival time (CAT) on the final appearance of the curves. Fourteen dogs with cytohistopathological diagnoses were included (seven malignant and seven inflammatory lesions). B-mode ultrasound was performed followed by CEUS examination after an intravenous bolus injection of 0.04 mL/kg of contrast medium, and TICs were elaborated by dedicated software. Receiver operating characteristic curves (ROC) for each TIC parameter were obtained. Neoplastic lesions had subjectively shorter rise time (RT), time to peak (TTP) and fall time (FT) than inflammatory lesions. Based on ROC curve analyses, fall time ≥ 10.49 s was the most reliable parameter for diagnosing non-neoplastic disease in this small sample of dogs (area under the curve [AUC] 0.75, sensitivity 83.33%, specificity 66.67%). No difference was found between ROCs calculated for each parameter of TICs by adding or removing CAT. Results of the current study provide background for future, larger scale studies evaluating use of a CEUS FT threshold of 10.49 s as a possible discriminator for urinary bladder neoplastic lesions in dogs.

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Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

Ercolin,

Uchoa,

Aires

et al. 2023

Preprint

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The aim of this literature review was to present the novel imaging modalities elastography and contrast-enhanced ultrasonography. We provided an overview of the concepts and applications of each technique for the investigation of neoplastic and metastatic tumors in dogs and cats. Studies with elastography are based on the elasticity and deformation of the evaluated tissue. The information obtained from the different types of elastography can aid in the detection and differentiation of malignant and benign structures. Descriptions of elastographic studies in several organs and tissue in veterinary medicine reported that, in general, malignant tumors tend to be more rigid, and, therefore, less deformable than benign lesions or in comparison to the healthy parenchyma. Contrast-enhanced ultrasonography is based on the intravenous injection of contrast media constituted by microbubbles. This imaging modality can be performed in non-sedated animals and provides information on the tissue perfusion, allowing the investigation of macro- and micro-circulation. Studies with different organs and tissues were performed in dogs and cats and revealed a tendency of malignant tumors to present faster transit of the contrast media (time to wash-in, peak and wash-out). These advanced techniques can be associated with other imaging modalities, aiding important information to the well-established exams of B-mode and Doppler ultrasonography. They can be used as screening tests, potentially representing an alternative to the invasive sampling methods required for cytological and histopathological analysis.

show abstract

Fall time may be a reliable discriminator between neoplastic and non‐neoplastic urinary bladder lesions in dogs undergoing contrast‐enhanced ultrasound: a pilot study

Cited by 3 publications

References 34 publications

Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

Fall time may be a reliable discriminator between neoplastic and non‐neoplastic urinary bladder lesions in dogs undergoing contrast‐enhanced ultrasound: a pilot study

Use of New Ultrasonography Methods for Detecting Neoplasms in Dogs and Cats: A Review

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