Fall in the number of intracardiac neurons in aging rats

Akamatsu, Flávia Emi; De-Souza, Romeu Rodrigues; Liberti, Édson Aparecido

doi:10.1016/s0047-6374(99)00023-8

Cited by 25 publications

(17 citation statements)

References 21 publications

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“…With regard to the reduced MIBG uptake and increased MIBG washout rate with aging, several mechanisms have been postulated. Animal studies report a diminished number of neurons in the heart with aging, 23,24 and increased central sympathetic nervous activity with aging has been reported by the MSNA studies, [12][13][14] as well as attenuation of parasympathetic nerve activity with advanced aging, 9,25,26 all pof which may contribute to the age-related changes in MIBG parameters. Furthermore, over the age of 50 years, Esler et al found that extraction of tritiated norepinephrine across the heart is reduced in healthy human subjects, suggesting an age-related reduced neuronal uptake of norepinephrine at presynaptic sites.…”

Section: Mechanisms Contributing To Physiological Changesmentioning

confidence: 89%

Physiological Changes in Human Cardiac Sympathetic Innervation and Activity Assessed by 123I-Metaiodobenzylguanidine (MIBG) Imaging

Sakata

Iida

Mochizuki

et al. 2009

Circ J

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he sympathetic nervous system (SNS) is an important control mechanisms of the body, dysfunction of which is well known to be associated with the development of various common cardiovascular diseases, such as ischemic heart disease, 1 congestive heart failure, 2 arrhythmias, 3 and sudden death. 4 It is also well known that the frequency and the onset of these diseases have age-and gender-related differences. 5,6 Likewise, the SNS shows physiologic fluctuations with age and sex, 7-15 which are considered to be related to gender differences in the frequency of cardiovascular diseases and the markedly increased risk of cardiovascular diseases with aging. Therefore, it is very important to assess physiological changes in sympathetic cardiovascular control in humans, especially in the cardiac SNS, because many cardiovascular diseases originate from the heart. However, as there are no appropriate methods of measuring the cardiac SNS in vivo, the precise physiological changes remain unclear.123 I-metaiodobenzylguanidine (MIBG) imaging has become widely used to evaluate human cardiac sympathetic nervous function [14][15][16][17][18][19][20] because it gives information about cardiac sympathetic nerve endings. Using MIBG imaging, the aim of this study was to assess the age-and gender-related differences in the global cardiac SNS in normal subjects. Methods PatientsWe investigated 153 patients whose ages ranged from 40 to 89 years were referred for cardiac catheterization because of chest pain or electrocardiogram (ECG) abnormality, and which revealed a nearly normal coronary artery without coronary spasm induced by acetylcholine and with normal cardiac function and hemodynamics. After cardiac catheterization, they underwent MIBG imaging. The subjects were 74 men and 79 women who did not have obvious heart disease, hypertension (≥140 mmHg systolic blood pressure, or ≥90 mmHg diastolic blood pressure), obesity (body mass index (BMI) >25 kg/m 2 ), diabetes mellitus or any other diseases affecting the autonomic nervous system. In addition, they did not take any drugs known to affect MIBG kinetics. We included 10 women who fulfilled the inclusion criteria and had undergone surgical menopause without oral hormone replacement therapy before physiological menopause because we wanted to investigate the effect of menopause on the cardiac SNS. Written informed consent was given by the each patient and the study was approved by the hospital's ethics committee. Cardiac CatheterizationAfter right-heart catheterization with a Swan-Ganz catheter, all patients underwent coronary angiography (CAG) performed by the Judkins technique. Prior to CAG, a tem- Michitoshi Ito, RT*; Yoshihiro Nakaya, RT* Background Physiologic changes in the human sympathetic nervous system (SNS) may be associated with cardiovascular diseases, so the present study assessed the age and gender differences in global cardiac SNS in normal subjects. Methods and ResultsThe 163 subjects (74 men, 89 women; age range 40-89 years) whose coronary arteriogram was normal, and w...

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Section: Mechanisms Contributing To Physiological Changesmentioning

confidence: 89%

Physiological Changes in Human Cardiac Sympathetic Innervation and Activity Assessed by 123I-Metaiodobenzylguanidine (MIBG) Imaging

Sakata

Iida

Mochizuki

et al. 2009

Circ J

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“…This finding is not confined only to the small intestine, but also in the colon and rectum in 3-and 24-month-old rats [27]. An increase in the size of neurons with age is not typical for the rat enteric nervous plexus [1]. A neuronal loss in intracardiac ganglia and increase of connective tissue was also accompanied by an increase in the size of the remaining neurons.…”

Section: Discussionmentioning

confidence: 84%

The effects of quercetin on liver regeneration after liver resection in rats

Mandic¹,

Leštarević

Filipović³

et al. 2016

Folia Morphol

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“…The cardiac neurons are located at least in 4 distinct groups, all above the atrioventricular groove [6]. Retrogradely transported The number of cardiac neurons may be decreased through several factors such as aging [1], diabetes [14,23] or infectious diseases such as the Chagas disease [24]. As cardiac neurons are part of the cholinergic system of the heart, a decrease in their number induce severe increase in chronotropic response to vagal stimulation [15,21,22,29].…”

Section: Discussionmentioning

confidence: 99%

“…Both the number and size of neurons may be modified by several factors. In a range of studies the neuron number and sizes have appeared as significant indexes displaying the age-related alterations in the intrinsic neurons of the trachea [3], small intestine [9,12] and heart [1]. Furthermore, counting of neurons and determination of neuron sizes have played an important role in studies that were aimed to analise the effects of pre-natal undernutrition on the rat intestines [2,25] as well as the effect of the Chagasic infection on the rat heart [ (7].…”

Section: Introductionmentioning

confidence: 99%

Training alters cardiac neuron sizes in Wistar rats

Souza¹,

Gama²,

Santarém³

et al. 2009

Biol Sport

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Abstract. The action of the parasympathetic nerves on the heart is made through a group of neurons located on the surface of the atria. This study evaluated the effect of a chronic training protocol on the number and sizes of the cardiac neurons of Wistar rats. Whole mount preparations of the atria of 12-month old male sedentary and trained rats (40 weeks of running on a treadmill 3 times a week, 16 m/min) were assessed for number and size (maximal cellular profile area) of the cardiac neurons. The cardiac neurons were ascertained by using the NADH-diaphorase technique that stains the cell bodies of the neurons in dark blue. The number of cardiac neurons in the trained rats (P>0.05) did not change significantly. In the sedentary group there were small, medium sized and large neurons. However there was a notable increase in the percentage of small neurons in the rats submitted to the training compared to the sedentary group (P<0.05). Previous studies have shown that electrophysiologically, the small neurons are more easily excitable than the large neurons. It is possible that the results of the present work reflect an adaptation mechanism of the cardiac neurons presumably with the objective of increasing the excitability of the neurons for the vagal action and resulting facilitation of the sinusal bradycardia observed at rest and in the exercise. We concluded that the training affects significantly the size of the cardiac neurons in Wistar rats.

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Fall in the number of intracardiac neurons in aging rats

Cited by 25 publications

References 21 publications

Physiological Changes in Human Cardiac Sympathetic Innervation and Activity Assessed by 123I-Metaiodobenzylguanidine (MIBG) Imaging

Physiological Changes in Human Cardiac Sympathetic Innervation and Activity Assessed by 123I-Metaiodobenzylguanidine (MIBG) Imaging

The effects of quercetin on liver regeneration after liver resection in rats

Training alters cardiac neuron sizes in Wistar rats

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