HighlightsAntigenotoxic effect of septilin against cyclophosphamide (CP) an anticancer drug was evaluated in Swiss albino mice.In vivo micronucleus (MN) assays and sperm shape abnormality assay were used as test parameters.Pretreatment with septilin significantly decreased the clastogenic damage induced by CP.Protective effect of septilin may be due to the synergistic effects of individual plants/their constituents.