Failure to achieve tight control of plasma cholesterol and apolipoprotein B with intraperitoneal insulin infusion in type 1 diabetes

Normalization of Lipoprotein Composition by Intraperitoneal Insulin in IDDM: Role of increased hepatic lipase activity

“…The VLDL data of this study do not agree with our previous report (23), where we observed a decrease of triglycerides and apoB in VLDL and also an increase of VLDL triglyceride:apoB ratio during intraperitoneal regimen. The two studies differ in degree of metabolic control and in peripheral insulin levels during subcutaneous insulin therapy; most of the differences among the various studies (20)(21)(22)(23)(24) are certainly attributable to these two variables.…”

“…Experiments in diabetic dogs have demonstrated that intraperitoneal insulin is almost entirely absorbed by the portal circulation (19). Reported changes in lipoprotein concentration and composition in IDDM patients treated with intraperitoneal insulin (20)(21)(22)(23)(24), however, have been contradictory; this may be attributable to the many intrinsic differences of patients, like different degrees of glucose control and different duration of follow-up.…”