Failure of Prolonged Treatment of Chronic Urinary-Tract Infections with Antibiotics

Turck, Marvin; Browder, Ann A.; Lindemeyer, Robert I.; Brown, Norman K.; Anderson, Kenneth N.; Petersdorf, Robert G.

doi:10.1056/nejm196211152672001

Cited by 56 publications

(14 citation statements)

References 16 publications

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“…The good follow-up cure rate in acute infections without urinary-tract abnormality (89 %) and the rather poor followup response of chronic infections (29.5 %) are similar to the results previously reported on treatment of urinary infections using various agents (Rhoads et al, 1952;Garrod et al, 1954;Kass, 1955;Turck et al, 1962).…”

Section: Resultssupporting

confidence: 88%

“…The evaluation of any new antibacterial agent in the treatment of infections of the urinary tract is made more difficult by the spontaneous cures which may occur in the absence of antibacterial treatment, particularly in patients without a previous history of urinary infection, and also after correction of abnormalities of, the urinary tract (Kass, 1955;Turck et al, 1962). From the results obtained in this trial, however, nalidixic acid would seem to be of value in the treatment of infections of the urinary tract, particularly those associated with coliform organisms and Proteus sp.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Nalidixic Acid in Infections of Urinary Tract

Barlow¹

1963

BMJ

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Nalidixic Acid in Infections of Urinary Tract

Barlow¹

1963

BMJ

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“…It is interesting to note that Pryles and Eliot's series was carried out in their renal clinic, and may, therefore, have included a higher proportion of bacteriuria without pyuria. Clarke (1960) and Turck, Browder, Lindemeyer, Brown, Anderson, and Petersdorf (1962) suggested that bacteriuria without pyuria is not uncommon in chronic and recurrent urinary infection, and our experience has substantiated this. However, in the present series no attempt was made to correlate pyuria and bacteriuria in children with known renal tract pathology.…”

Section: Resultssupporting

confidence: 70%

Pyuria and bacteriuria.

Lam¹,

Bremner²,

Maxwell³

et al. 1967

Archives of Disease in Childhood

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“…Our results, both in the whole series and in infections by individual organisms, agree broadly with those of Carroll (1963) and those of the authors already quoted. The cure rate in acute infections (23 out of 26) and in chronic infections (14 out of 26) is similar to, and in chronic infections better than, results reported by Barlow (1963) -with nalidixic acid and previous authors using various agents (Rhoads et al, 1952;Garrod et al, 1954;Kass, 1955;Turck et al, 1962). Our figures would have been better had we treated only sensitive organisms and omitted the eight failed cases due to insensitive organisms.…”

Section: Results Of Treatmentsupporting

confidence: 87%

Nalidixic Acid in Urinary Infections

Ward-McQuaid¹,

Jichlinski²,

Macis³

1963

BMJ

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Nalidixic acid (" negram ") is one of a new series of 1,8-naphthyridine derivatives with antibacterial properties which have been synthesized by Lesher et al. (1962). Chemically it is 1-ethyl-7-methyl-1,8-naphthyridine-4-one-3-carboxylic mg./kg. throughout pregnancy and for one week afterwards. On these dose levels there were no adverse effects on the course of pregnancy or on the growth and survival capacities of the offspring. At the highest dose level of 300 mg./kg., which is that approaching the limit of rat tolerance, there was maternal mortality and interference with the course of pregnancy of the survivors. At the end of the study there was no evidence of gross disease among survivors at all dose levels. Doses of 200 mg. /kg./day were given to three pregnant monkeys. One animal was medicated for two months and others for one month prior to delivery. The drug was given to all animals during the first two weeks post partum. No untoward reactions were noted. Each mother delivered one normal offspring, and mothers and offspring were observed for three months after stopping medication and appeared normal during this time. The body weight of the mothers was normal throughout the study. The Somers test has been repeated using pregnant rabbits; no teratogenic changes or other congenital malformations were observed. Human VolunteersThe drug was given to 13 men and 9 women four times a day for up to 180 successive days. The maximum sustained dose was 8 g./day for 56 days. An initial single 4-g. dose was well tolerated by most volunteers. Clinical TrialMid-stream specimens of urine were collected in both sexes except when a specimen was taken at the time of cystoscopy. The urines were refrigerated and cultured within an hour of arrival in the laboratory.

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Failure of Prolonged Treatment of Chronic Urinary-Tract Infections with Antibiotics

Cited by 56 publications

References 16 publications

Nalidixic Acid in Infections of Urinary Tract

Nalidixic Acid in Infections of Urinary Tract

Pyuria and bacteriuria.

Nalidixic Acid in Urinary Infections

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