Failure of ejaculation with indoramin.

Abstract

1433urinary excretion rose to 2 17 1/24 h, with chloride 249 mmol/24 h and potassium 178 mmol/24 h. Mean fall in body weight was 0-29 kg/day. The patient became oedema free over two weeks.Case 4-A 40-year-old man with severe ischaemic heart disease presented with congestive cardiac failure. CommentAdding relatively small doses of metolazone to high-dose "loop" diuretics significantly increased urine volume and excretion of sodium chloride and potassium, enabling body weight to fall and oedema to clear. The response was immediate and sustained. An initial dose of 2-5 mg metolazone is recommended. Profound natriuresis with associated kaliuresis may lead to hypovolaemia and hypokalaemia respectively. These complications should be anticipated by gradual dose titration according to urine volume and changes in body weight and adequate potassium supplementation. Ideally the patient should be treated with caution in hospital, as dangerous, uncontrolled losses of fluid and electrolytes may occur.4We are grateful to Sisters M Morris and G Alcock for metabolic nursing, and to Miss J E Davies for secretarial work.

A method for monitoring drug effects on male sexual response: the effect of single dose labetalol.

“…Drugs possessing aadrenoceptor antagonist activity are known to impair ejaculation. Failure of ejaculation occurred in twothirds of patients treated with indoramin in fairly low dosage (60 mg) for migraine (Pentland et al, 1981). Although failure of ejaculation has been reported to occur during treatment with labetalol it is an infrequent side effect.…”

Alpha-1 Blockers. A New Generation of Antihypertensive Agents

“…64); the incidence with doxazosin is about 3% (65), and prazosin has a similar incidence (15) and can cause priapism (66). Indoramin, which blocks a-1 and histamine-1 receptors (and, weakly, serotoninergic receptors) is associated with a much greater frequency of sexual dysfunction (1 5) and has also been reported to suppress ejaculation in a majority of patients (67). It has been suggested that the inhibition of a-1 adrenergic receptors should be investigated in the treatment of impotence (66).…”

Endogenous hydrogen sulfide as a mediator of vas deferens smooth muscle relaxation

“…Functional obstruction of the VD during orchiopexy causes infertility (1). Functional abnormalities of the VD arise after diabetes mellitus, and treatment with a-adrenergic blockers (2) may lead to hypospermia (2,3), emission, and premature ejaculation. Hydrogen sulfide (H 2 S), a new emerging gaseous signaling molecule (4-6), can be generated endogenously from L-cysteine (L-Cys) catalyzed by either cystathionine-synthase (CBS) or cystathionine-lyase (CSE).…”