Failure of cortisone and ACTH to regulate cardiac hypertrophy

The Mechanism of Training Effects: A Hypothesis

“…Cardiac hypertrophy that leads to an increase in heart weight by more than 15% is considered an expression of overadaptation exceeding the normal physiologic limits (67). The administration of cortisone to exercising rats did not change cardiac hypertrophy (72). However, in this experiment, an adrenal atrophy pointed to suppression of the production of endogenous glucocorticoids.…”

“…Hypercorticism might develop during training with corticotropin treatment. In this case, cardiac hypertrophy was somewhat less pronounced than in rats trained without any treatment (72). Ovariectomy did not change the training-induced cardiac hypertrophy (7).…”

Steric Aspects of Adrenergic Drugs

“…The pressor effects of nonphenolic amines are now recognized as being mediated through the release of catecholamines from the sympathetic nerve endings. Readers interested in earlier studies regarding optical isomers of nonphenolic amines are urged to read other reports (169)(170)(171)(172)(173)(174).…”