Fahr’s syndrome: a case of unwanted calcium in the brain

Sahu, Kamal Kant; Mishra, Ajay Kumar; Lal, Amos; Gandhi, Rahul

doi:10.1007/s11739-019-02119-y

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Calcium deposition and related manifestations could be rare and, hence challenging. In those scenarios, available data in the literature in addition to the evidence‐based knowledge could be beneficial for diagnosis and treatment …”

Section: Demographic Characteristics Of the Patients Suffering From Cmentioning

confidence: 99%

Calciphylaxis: Continues to surprise

et al. 2019

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Section: Demographic Characteristics Of the Patients Suffering From Cmentioning

confidence: 99%

Calciphylaxis: Continues to surprise

et al. 2019

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“…Basal ganglia calcifications could be "physiological" (such as in patients over 50 years) but also an incidental CT finding in 15-20% of asymptomatic patients [1]. However, in less than 1/1,000,000 of cases, it has clinical significance, being associated with an extremely rare disorder characterized by bilateral symmetrical calcifications of the basal ganglia and the cerebral cortex, denominated as Fahr's syndrome [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…The metabolic causes include hypoparathyroidism, pseudohypoparathyroidism, hypothyroidism, toxins such as lead and hypervitaminosis D. The infectious causes include toxoplasmosis, rubella, cytomegalovirus, neurocysticercosis, HIV and tuberculosis. It could also be due to rarer genetic disorders such as neurofibromatosis, tuberous sclerosis, Cockayne syndrome, Wilson's disease [3]. An important differential diagnosis is idiopathic calcifications, denominated as Fahr's disease.…”

Section: Introductionmentioning

confidence: 99%

Could Fahr’s Syndrome Have More Than One Simultaneous Etiology?

Palu¹,

Moraes²,

Romaniello³

et al. 2021

Cureus

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Fahr's syndrome is a rare, genetically dominant, inherited, neurological disorder characterized by abnormal deposits of calcium in the basal ganglia and the cerebral cortex. Symptoms include motor dysfunction, dementia, headache, spastic paralysis, abnormal ocular findings and seizures. Hypoparathyroidism is the most common endocrine disorder related to this syndrome, however, there are other metabolic, infectious and genetic causes. This is a case report of a Fahr's syndrome patient presenting a three-month history of self-limited partial epileptic seizures. His cranial CT had bilateral symmetrical calcifications of the basal ganglia, subcortical tissue and dentate nucleus whereas his laboratory findings were compatible with hypoparathyroidism.

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“…An expert opinion from dermatologist might be beneficial in cases with complex skin lesions when diagnosis is in question. [5] Deposition of calcium can compromise the organ function slowly and impair the architecture permanently[6].…”

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confidence: 99%