Faecal incontinence: the ‘Cinderella’ disorder

A randomised, controlled, crossover study to investigate the safety and response of 1R,2S‐methoxamine hydrochloride (NRL001) on anal function in healthy volunteers

“…The epidemiology, aetiology and treatment options of this common condition have been summarised previously [2]. The internal anal sphincter (IAS) is a critical component responsible for maintaining normal human faecal continence.…”

“…Faecal incontinence is a common, socially debilitating condition defined as continuous or recurrent uncontrolled passage of faecal material (solid, liquid or gas) for at least 3 months . The epidemiology, aetiology and treatment options of this common condition have been summarised previously . The internal anal sphincter (IAS) is a critical component responsible for maintaining normal human faecal continence.…”

Randomised clinical trial: study of escalating doses of NRL001 given in rectal suppositories of different weights

“…This results in embarrassment, distress and an impaired quality of life, as the ability to remain continent is fundamental to our functioning as socially capable individuals . The epidemiology, and aetiology of faecal incontinence, as well as current treatment strategies, have been reviewed previously . Despite the range of management options available, many patients do not achieve complete continence, therefore further treatments are needed to improve outcomes.…”